U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C15H14N4O.ClH.3H2O
Molecular Weight 356.805
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SENAZODAN HYDROCHLORIDE TRIHYDRATE

SMILES

O.O.O.Cl.O=C1CCC(=NN1)C2=CC=C(NC3=CC=NC=C3)C=C2

InChI

InChIKey=KQXCWCFBLZWIGE-UHFFFAOYSA-N
InChI=1S/C15H14N4O.ClH.3H2O/c20-15-6-5-14(18-19-15)11-1-3-12(4-2-11)17-13-7-9-16-10-8-13;;;;/h1-4,7-10H,5-6H2,(H,16,17)(H,19,20);1H;3*1H2

HIDE SMILES / InChI
Molecular Formula C15H14N4O
Molecular Weight 266.2979
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Senazodan (previously known as MCI 154), a positive inotropic agent that inhibits phosphodiesterase III and possesses a vasodilating property. Senazodan was studied in the phase II clinical trial in Japan in patients with acute heart failure. However, this study was discontinued.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Stimulation of myocardium during reperfusion injury by a new inotrope-vasodilator agent, MCI-154.
1987
Does the positive inotropic action of a novel cardiotonic agent, MCI-154, involve mechanisms other than cyclic AMP?
1987 Nov
Effects of MCI-154 on Ca2+ activation of skinned human myocardium.
1989 Jun 20
High selectivity for inhibition of phosphodiesterase III and positive inotropic effects of MCI-154 in guinea pig myocardium.
1993 Jun
Inotropic therapy of heart failure. Editorial comments on: Vasodilation and mechanoenergetic inefficiency dominates the effect of the "Ca2+ sensitizer" MCI-154 in intact pigs.
2002 May
The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C.
2018 Dec
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:36:55 GMT 2023
Edited
by admin
on Sat Dec 16 08:36:55 GMT 2023
Record UNII
WB65Y3B8VX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SENAZODAN HYDROCHLORIDE TRIHYDRATE
Common Name English
MCI-154 TRIHYDRATE
Code English
3(2H)-PYRIDAZINONE, 4,5-DIHYDRO-6-(4-(4-PYRIDINYLAMINO)PHENYL)-, HYDROCHLORIDE, HYDRATE (1:1:3)
Systematic Name English
3(2H)-PYRIDAZINONE, 4,5-DIHYDRO-6-(4-(4-PYRIDINYLAMINO)PHENYL)-, MONOHYDROCHLORIDE, TRIHYDRATE
Systematic Name English
Code System Code Type Description
CAS
474941-42-9
Created by admin on Sat Dec 16 08:36:55 GMT 2023 , Edited by admin on Sat Dec 16 08:36:55 GMT 2023
PRIMARY
FDA UNII
WB65Y3B8VX
Created by admin on Sat Dec 16 08:36:55 GMT 2023 , Edited by admin on Sat Dec 16 08:36:55 GMT 2023
PRIMARY
PUBCHEM
9906730
Created by admin on Sat Dec 16 08:36:55 GMT 2023 , Edited by admin on Sat Dec 16 08:36:55 GMT 2023
PRIMARY
Related Record Type Details
Structure of SENAZODAN HYDROCHLORIDE
ANHYDROUS->SOLVATE
Structure of SENAZODAN
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of SENAZODAN
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966