FELZARTAMAB

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 05:10:52 GMT 2025` Edited by `admin` on `Wed Apr 02 05:10:52 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|LAMDA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	3O9FA4XC02
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FELZARTAMAB

Official Name

English

felzartamab [INN]

Preferred Name

English

ANTI-CD38 MONOCLONAL ANTIBODY MOR03087

Common Name

English

TJ-202

Code

English

TJ202

Code

English

MOR202

Common Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN CD38 ANTIGEN) (HUMAN MONOCLONAL MOR03087 .GAMMA.-1 CHAIN), DISULFIDE WITH HUMAN MONOCLONAL MOR03087 .LAMBDA.-CHAIN, DIMER

Common Name

English

HUMAN RECOMBINANT IgG1 LAMBDA ANTI-CLUSTER OF DIFFERENTIATION 38 MONOCLONAL ANTIBODY EX HUMAN PER.C6 CELL LINE MOR202

Common Name

English

Felzartamab [WHO-DD]

Common Name

English

MOR-202

Code

English

MOR03087

Code

English

MOR-03087

Code

English

IMMUNOGLOBULIN G1-LAMBDA, ANTI-(HOMO SAPIENS CD38 (ADP-RIBOSYL CYCLASE 1, CYCLIC ADP-RIBOSE HYDROLASE 1, CADPR HYDROLASE 1, T10)), HUMANIZED MONOCLONAL ANTIBODY

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

939423

Created by admin on Wed Apr 02 05:10:52 GMT 2025 , Edited by admin on Wed Apr 02 05:10:52 GMT 2025

Code System Code Type Description

SMS_ID

300000023871

Created by admin on Wed Apr 02 05:10:52 GMT 2025 , Edited by admin on Wed Apr 02 05:10:52 GMT 2025

PRIMARY

INN

11074

Created by admin on Wed Apr 02 05:10:52 GMT 2025 , Edited by admin on Wed Apr 02 05:10:52 GMT 2025

PRIMARY

FDA UNII

3O9FA4XC02

Created by admin on Wed Apr 02 05:10:52 GMT 2025 , Edited by admin on Wed Apr 02 05:10:52 GMT 2025

PRIMARY

CAS

2197112-39-1

Created by admin on Wed Apr 02 05:10:52 GMT 2025 , Edited by admin on Wed Apr 02 05:10:52 GMT 2025

PRIMARY

NCI_THESAURUS

C97954

Created by admin on Wed Apr 02 05:10:52 GMT 2025 , Edited by admin on Wed Apr 02 05:10:52 GMT 2025

PRIMARY

From	To
1_22	1_96
1_147	1_203
1_223	3_212
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428
2_22	2_96
2_147	2_203
2_223	4_212
2_264	2_324
2_370	2_428
3_22	3_87
3_135	3_194
4_22	4_87
4_135	4_194

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					JMN849I3XV

ADP-RIBOSYL CYCLASE/CYCLIC ADP-RIBOSE HYDROLASE 1

TARGET -> INHIBITOR

Comments:

ADCC and ADCP are considered to be primary modes of action for MOR202 targeting CD38 high expressing cells.

Qualification:

EC50

Amount:

Related Record Type Details


					3O9FA4XC02

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
FRACTION REMOVED	[1_450] [2_450]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL