U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 13:20:42 GMT 2023
Edited
by admin
on Sat Dec 16 13:20:42 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
JMN849I3XV
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ADP-RIBOSYL CYCLASE/CYCLIC ADP-RIBOSE HYDROLASE 1
Common Name English
ADPRC 1
Common Name English
CADPR HYDROLASE 1
Common Name English
ADP-RIBOSYL CYCLASE 1
Common Name English
2'-PHOSPHO-ADP-RIBOSYL CYCLASE
Common Name English
2'-PHOSPHO-CYCLIC-ADP-RIBOSE TRANSFERASE
Common Name English
CD38
Common Name English
T10
Common Name English
2'-PHOSPHO-ADP-RIBOSYL CYCLASE/2'-PHOSPHO-CYCLIC-ADP-RIBOSE TRANSFERASE
Common Name English
CYCLIC ADP-RIBOSE HYDROLASE 1
Common Name English
Code System Code Type Description
UNIPROT
P28907
Created by admin on Sat Dec 16 13:20:43 GMT 2023 , Edited by admin on Sat Dec 16 13:20:43 GMT 2023
PRIMARY
FDA UNII
JMN849I3XV
Created by admin on Sat Dec 16 13:20:43 GMT 2023 , Edited by admin on Sat Dec 16 13:20:43 GMT 2023
PRIMARY
From To
1_67 1_82
1_99 1_180
1_160 1_173
1_254 1_275
1_287 1_296
Glycosylation Link Type Site
N 1_100
N 1_164
N 1_209
N 1_219
Related Record Type Details
INHIBITOR -> TARGET
depletes human tumor cells expressing CD38 by antibody-dependent cellular cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC).
INHIBITOR -> TARGET
ADCC and ADCP are considered to be primary modes of action for MOR202 targeting CD38 high expressing cells.
EC50
LIGAND->TARGET
LIGAND->TARGET
RADIOLIGAND->TARGET
LIGAND->TARGET
INHIBITOR -> TARGET
SUBSTRATE -> METABOLIC ENZYME
LIGAND->TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL