ADP-RIBOSYL CYCLASE/CYCLIC ADP-RIBOSE HYDROLASE 1

Approval Year

Substance Class	Protein
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	JMN849I3XV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ADP-RIBOSYL CYCLASE/CYCLIC ADP-RIBOSE HYDROLASE 1

Common Name

English

ADPRC 1

Common Name

English

CADPR HYDROLASE 1

Common Name

English

ADP-RIBOSYL CYCLASE 1

Common Name

English

2'-PHOSPHO-ADP-RIBOSYL CYCLASE

Common Name

English

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Code System

Code

Type

Description

UNIPROT

P28907

PRIMARY

FDA UNII

JMN849I3XV

PRIMARY

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Subunit 0

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From	To
1_67	1_82
1_99	1_180
1_160	1_173
1_254	1_275
1_287	1_296

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Glycosylation Link Type	Site
N	1_100
N	1_164
N	1_209
N	1_219

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Type

Details


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Comments:

depletes human tumor cells expressing CD38 by antibody-dependent cellular cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC).


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INHIBITOR -> TARGET

Comments:

ADCC and ADCP are considered to be primary modes of action for MOR202 targeting CD38 high expressing cells.

Qualification:

EC50

Amount:

2.9 [2.4 to 3.2] (average)


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Amount:


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LIGAND->TARGET


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Amount:

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 34300 Da (average)

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