RAZAXABAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H20F4N8O2
Molecular Weight	528.4616
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CC1=NC=CN1C2=CC=C(NC(=O)C3=CC(=NN3C4=CC5=C(ON=C5N)C=C4)C(F)(F)F)C(F)=C2

InChI

InChIKey=OFJRNBWSFXEHSA-UHFFFAOYSA-N

InChI=1S/C24H20F4N8O2/c1-34(2)12-21-30-7-8-35(21)13-3-5-17(16(25)10-13)31-23(37)18-11-20(24(26,27)28)32-36(18)14-4-6-19-15(9-14)22(29)33-38-19/h3-11H,12H2,1-2H3,(H2,29,33)(H,31,37)

HIDE SMILES / InChI

Molecular Formula	C24H20F4N8O2
Molecular Weight	528.4616
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17984286 | http://williams.medicine.wisc.edu/new_oral_anticoagulants_2011.pdf | https://www.ncbi.nlm.nih.gov/pubmed/15771420

Razaxaban (also known as BMS-561389 or DPC 906) is an oral factor Xa inhibitor that was being developed for the treatment of thrombosis. It showed excellent results in the lab for efficacy and bioavailability and was therefore selected for further development. In a phase 1 clinical trial with healthy subjects, Razaxaban was well tolerated with minor bleeding. However, higher bleeding was reported in thrombosis patients in a phase 2 clinical trial, and the development of this drug was therefore discontinued in 2005.

Originator

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:13:37 UTC 2023` Edited by `admin` on `Fri Dec 15 17:13:37 UTC 2023`
Record UNII	3K2509846L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RAZAXABAN

Official Name

English

1-(3-AMINO-1,2-BENZISOXAZOL-5-YL)-N-(4-(2-((DIMETHYLAMINO)METHYL)-1H-IMIDAZOL-1-YL)-2-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE

Systematic Name

English

1H-PYRAZOLE-5-CARBOXAMIDE, 1-(3-AMINO-1,2-BENZISOXAZOL-5-YL)-N-(4-(2-((DIMETHYLAMINO)METHYL)-1H-IMIDAZOL-1-YL)-2-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)-

Systematic Name

English

razaxaban [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C263