RAZAXABAN HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H20F4N8O2.ClH
Molecular Weight	564.923
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CN(C)CC1=NC=CN1C2=CC=C(NC(=O)C3=CC(=NN3C4=CC5=C(ON=C5N)C=C4)C(F)(F)F)C(F)=C2

InChI

InChIKey=CASCTHHMARGRLB-UHFFFAOYSA-N

InChI=1S/C24H20F4N8O2.ClH/c1-34(2)12-21-30-7-8-35(21)13-3-5-17(16(25)10-13)31-23(37)18-11-20(24(26,27)28)32-36(18)14-4-6-19-15(9-14)22(29)33-38-19;/h3-11H,12H2,1-2H3,(H2,29,33)(H,31,37);1H

HIDE SMILES / InChI

Molecular Formula	C24H20F4N8O2
Molecular Weight	528.4616
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17984286 | http://williams.medicine.wisc.edu/new_oral_anticoagulants_2011.pdf | https://www.ncbi.nlm.nih.gov/pubmed/15771420

Razaxaban (also known as BMS-561389 or DPC 906) is an oral factor Xa inhibitor that was being developed for the treatment of thrombosis. It showed excellent results in the lab for efficacy and bioavailability and was therefore selected for further development. In a phase 1 clinical trial with healthy subjects, Razaxaban was well tolerated with minor bleeding. However, higher bleeding was reported in thrombosis patients in a phase 2 clinical trial, and the development of this drug was therefore discontinued in 2005.

Originator

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:42:24 GMT 2023` Edited by `admin` on `Fri Dec 15 15:42:24 GMT 2023`
Record UNII	7CLJ1MEZ8V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RAZAXABAN HYDROCHLORIDE

Official Name

English

RAZAXABAN HCL

Common Name

English

1H-PYRAZOLE-5-CARBOXAMIDE, 1-(3-AMINO-1,2-BENZISOXAZOL-5-YL)-N-(4-(2-((DIMETHYLAMINO)METHYL)-1H-IMIDAZOL-1-YL)-2-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)-, MONOHYDROCHLORIDE

Common Name

English

1-(3-Amino-1,2-benzisoxazol-5-yl)-N-[4-[2-[(dimethylamino)methyl]-1H-imidazol-1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide monohydrochloride

Systematic Name

English

BMS-561389

Code

English

RAZAXABAN HYDROCHLORIDE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C263