FACTOR XA

Approval Year

Substance Class	Protein
Protein Type	COAGULATION FACTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	HYF6HN9XGQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FACTOR XA

Common Name

English

Factor x (stuart prower factor) [WHO-DD]

Preferred Name

English

STUART-PROWER FACTOR

Common Name

English

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Code System

Code

Type

Description

FDA UNII

HYF6HN9XGQ

PRIMARY

LACTMED

Factor Xa (recombinant), Inactivated

PRIMARY

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Subunit 0

Subunit 1

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From	To
1_181	1_209
1_156	1_170
1_108	2_132
1_27	1_43
1_7	1_12

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Related Record

Type

Details


					K9GJ38KJ9F

YM-466 free base

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

7.7 NANOMOLAR (average)


					S173RED00L

OTAMIXABAN

INHIBITOR -> TARGET

Amount:


					0LN50R4A7P

KVD-001

NON-INHIBITOR->OFF TARGET

Amount:

[>10] MICROMOLAR (average)


					74RWP7W0J9

BETRIXABAN

INHIBITOR -> TARGET


					J177FOW5JL

FONDAPARINUX

INHIBITOR -> TARGET

Amount:

Showing 1 to 5 of 23 entries

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[2_6] [2_7] [2_14] [2_16] [2_19] [2_20] [2_25] [2_26] [2_29] [2_31] [2_39] [2_40]		GLUTAMIC ACID		.GAMMA.-CARBOXYGLUTAMIC ACID	16FQV4RZKL
AMINO ACID SUBSTITUTION	[2_63]		ASPARTIC ACID		.BETA.-HYDROXY-L-ASPARTIC ACID, ERYTHRO-	GDV0MSK2SG

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C1921H2994N535O649S31
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 48400 Da (average)

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