HENAGLIFLOZIN

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H24ClFO7
Molecular Weight	454.873
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC1=C(F)C=C(CC2=C(Cl)C=CC(=C2)[C@@]34OC[C@@](CO)(O3)[C@@H](O)[C@H](O)[C@H]4O)C=C1

InChI

InChIKey=HYTPDMFFHVZBOR-VNXMGFANSA-N

InChI=1S/C22H24ClFO7/c1-2-29-17-6-3-12(8-16(17)24)7-13-9-14(4-5-15(13)23)22-20(28)18(26)19(27)21(10-25,31-22)11-30-22/h3-6,8-9,18-20,25-28H,2,7,10-11H2,1H3/t18-,19-,20+,21+,22+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H24ClFO7
Molecular Weight	454.873
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26692004 | https://clinicaltrials.gov/ct2/show/NCT02346175

Henagliflozin (also known as SHR3824) was developed by Jiangsu HengRui Medicine as a sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus. This drug successfully passed phase I clinical trials, however, information about further development is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Evaluation of drug-drug interaction between henagliflozin, a novel sodium-glucose co-transporter 2 inhibitor, and metformin in healthy Chinese males.	2016-08	26608671
Pharmacokinetics and Pharmacodynamics of Henagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, in Chinese Patients with Type 2 Diabetes Mellitus.	2016-03	26692004
SHR3824, a novel selective inhibitor of renal sodium glucose cotransporter 2, exhibits antidiabetic efficacy in rodent models.	2014-05	24786232

Sample Use Guides

In Vivo Use Guide

to evaluate the pharmacodynamics (PD), pharmacokinetics (PK), safety and tolerability following single and multiple oral doses of 5mg to 20 mg SHR3824 in Type 2 diabetes mellitus patients.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:38:24 GMT 2025` Edited by `admin` on `Mon Mar 31 18:38:24 GMT 2025`
Record UNII	21P2M98388
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SHR-3824

Preferred Name

English

HENAGLIFLOZIN

Common Name

English

Henagliflozin [WHO-DD]

Common Name

English

SHR3824

Code

English

.BETA.-D-GLUCOPYRANOSE, 1,6-ANHYDRO-1-C-(4-CHLORO-3-((4-ETHOXY-3-FLUOROPHENYL)METHYL)PHENYL)-5-C-(HYDROXYMETHYL)-

Systematic Name

English

((1R,2S,3S,4R,5R)-5-(4-CHLORO-3-(4-ETHOXY-3-FLUOROBENZYL)PHENYL)-1-(HYDROXYMETHYL)-6,8-DIOXABICYCLO(3.2.1)OCTANE-2,3,4-TRIOL

Systematic Name

English

Code System Code Type Description

FDA UNII

21P2M98388