Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H24ClFO7.C5H9NO2 |
| Molecular Weight | 570.004 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)[C@H]1CCCN1.CCOC2=CC=C(CC3=CC(=CC=C3Cl)[C@@]45OC[C@@](CO)(O4)[C@@H](O)[C@H](O)[C@H]5O)C=C2F
InChI
InChIKey=HSHUXRQZEKRWMX-CGDHVTPMSA-N
InChI=1S/C22H24ClFO7.C5H9NO2/c1-2-29-17-6-3-12(8-16(17)24)7-13-9-14(4-5-15(13)23)22-20(28)18(26)19(27)21(10-25,31-22)11-30-22;7-5(8)4-2-1-3-6-4/h3-6,8-9,18-20,25-28H,2,7,10-11H2,1H3;4,6H,1-3H2,(H,7,8)/t18-,19-,20+,21+,22+;4-/m01/s1
| Molecular Formula | C22H24ClFO7 |
| Molecular Weight | 454.873 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | C5H9NO2 |
| Molecular Weight | 115.1305 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Henagliflozin (also known as SHR3824) was developed by Jiangsu HengRui Medicine as a sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus. This drug successfully passed phase I clinical trials, however, information about further development is not available.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| SHR3824, a novel selective inhibitor of renal sodium glucose cotransporter 2, exhibits antidiabetic efficacy in rodent models. | 2014 May |
|
| Evaluation of drug-drug interaction between henagliflozin, a novel sodium-glucose co-transporter 2 inhibitor, and metformin in healthy Chinese males. | 2016 Aug |
|
| Pharmacokinetics and Pharmacodynamics of Henagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, in Chinese Patients with Type 2 Diabetes Mellitus. | 2016 Mar |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 15:33:40 GMT 2023
by
admin
on
Sat Dec 16 15:33:40 GMT 2023
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| Record UNII |
4IO819SW6M
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| Record Status |
Validated (UNII)
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| Record Version |
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4IO819SW6M
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300000040273
Created by
admin on Sat Dec 16 15:33:40 GMT 2023 , Edited by admin on Sat Dec 16 15:33:40 GMT 2023
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PARENT -> SALT/SOLVATE |
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