2-AMINOINDANE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H11N
Molecular Weight	133.1903
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1CC2=C(C1)C=CC=C2

InChI

InChIKey=LMHHFZAXSANGGM-UHFFFAOYSA-N

InChI=1S/C9H11N/c10-9-5-7-3-1-2-4-8(7)6-9/h1-4,9H,5-6,10H2

HIDE SMILES / InChI

Molecular Formula	C9H11N
Molecular Weight	133.1903
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
Alpha-2c adrenergic receptor 37 Target ID: CHEMBL1916 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940	Binding Agent 1064	41.0 nM [Ki]
Alpha-2b adrenergic receptor 27 Target ID: CHEMBL1942 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940	Binding Agent 1064	211.0 nM [Ki]
Alpha-2a adrenergic receptor 63 Target ID: CHEMBL1867 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940	Binding Agent 1064	134.0 nM [Ki]
Norepinephrine transporter 191 Target ID: CHEMBL222 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940	Substrate 661	86.0 nM [EC50]
Dopamine transporter 180 Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940	Substrate 661	439.0 nM [EC50]

PubMed

Title	Date	PubMed
Copper-containing monooxygenases: enzymatic and biomimetic studies of the O-atom transfer catalysis.	2002 Apr	12069196
Safety, pharmacokinetics, and pharmacodynamics of CHF 3381, a novel N-methyl-D-aspartate antagonist, after single oral doses in healthy subjects.	2003 Aug	12953347
Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties.	2004 Dec 6	15501040
Steady-state pharmacokinetics and pharmacodynamics of CHF3381, a novel antineuropathic pain agent, in healthy subjects.	2005 Apr	15801935
Conformations of 2-aminoindan in a supersonic jet: the role of intramolecular N-H...pi hydrogen bonding.	2007 Jul 12	17571864
Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain.	2007 Sep	17786847
Synthesis, dopaminergic profile, and molecular dynamics calculations of N-aralkyl substituted 2-aminoindans.	2008 Mar 15	18166467
[Analysis of designer drugs detected in the products purchased in fiscal year 2006].	2008 Oct	18827471
Synthesis and pharmacological evaluation of schiff bases of 4-(2-aminophenyl)-morpholines.	2009 Jul	20502549
Analgesic and anti-inflammatory activity of amifostine, DRDE-07, and their analogs, in mice.	2010 Feb	20606831
Analgesic effect of Lepidium sativum Linn. (Chandrashura) in experimental animals.	2010 Jul	22131742
The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline.	2010 Mar	20002521
The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.	2010 May 13	20402514

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:41:59 GMT 2023` Edited by `admin` on `Sat Dec 16 01:41:59 GMT 2023`
Record UNII	1P810SQ3EY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-AMINOINDANE

Systematic Name

English

2,3-DIHYDRO-1H-INDEN-2-AMINE

Systematic Name

English

1H-INDEN-2-AMINE, 2,3-DIHYDRO-

Systematic Name

English

INDANE-2-YLAMINE

Systematic Name

English

J80.606D

Code

English

2-INDANAMINE

Systematic Name

English

(2,3-DIHYDRO-1H-INDEN-2-YL)AMINE

Systematic Name

English

2-AI

Common Name

English

2-INDANYLAMINE

Systematic Name

English

2-AMINOINDAN

Systematic Name

English

INDAN-2-AMINE

Systematic Name

English

2-AMINO-2,3-DIHYDRO-1H-INDENE

Systematic Name

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-2-AI