Details
Stereochemistry | ACHIRAL |
Molecular Formula | C9H11N |
Molecular Weight | 133.1903 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1CC2=C(C1)C=CC=C2
InChI
InChIKey=LMHHFZAXSANGGM-UHFFFAOYSA-N
InChI=1S/C9H11N/c10-9-5-7-3-1-2-4-8(7)6-9/h1-4,9H,5-6,10H2
Molecular Formula | C9H11N |
Molecular Weight | 133.1903 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL1916 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940 |
41.0 nM [Ki] | ||
Target ID: CHEMBL1942 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940 |
211.0 nM [Ki] | ||
Target ID: CHEMBL1867 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940 |
134.0 nM [Ki] | ||
Target ID: CHEMBL222 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940 |
86.0 nM [EC50] | ||
Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940 |
439.0 nM [EC50] |
PubMed
Title | Date | PubMed |
---|---|---|
Copper-containing monooxygenases: enzymatic and biomimetic studies of the O-atom transfer catalysis. | 2002 Apr |
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Safety, pharmacokinetics, and pharmacodynamics of CHF 3381, a novel N-methyl-D-aspartate antagonist, after single oral doses in healthy subjects. | 2003 Aug |
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Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. | 2004 Dec 6 |
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Steady-state pharmacokinetics and pharmacodynamics of CHF3381, a novel antineuropathic pain agent, in healthy subjects. | 2005 Apr |
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Conformations of 2-aminoindan in a supersonic jet: the role of intramolecular N-H...pi hydrogen bonding. | 2007 Jul 12 |
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Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain. | 2007 Sep |
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Synthesis, dopaminergic profile, and molecular dynamics calculations of N-aralkyl substituted 2-aminoindans. | 2008 Mar 15 |
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[Analysis of designer drugs detected in the products purchased in fiscal year 2006]. | 2008 Oct |
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Synthesis and pharmacological evaluation of schiff bases of 4-(2-aminophenyl)-morpholines. | 2009 Jul |
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Analgesic and anti-inflammatory activity of amifostine, DRDE-07, and their analogs, in mice. | 2010 Feb |
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Analgesic effect of Lepidium sativum Linn. (Chandrashura) in experimental animals. | 2010 Jul |
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The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline. | 2010 Mar |
|
The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist. | 2010 May 13 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:41:59 GMT 2023
by
admin
on
Sat Dec 16 01:41:59 GMT 2023
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Record UNII |
1P810SQ3EY
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Record Status |
Validated (UNII)
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Record Version |
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WIKIPEDIA |
Designer-drugs-2-AI
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SUB181269
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2975-41-9
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100000166971
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DTXSID40183902
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221-021-3
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2-Aminoindan
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76310
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
SD Rats (male)
IN-VIVO
Scientific Literature
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ACTIVE MOIETY |
Analgesic potency (ED50) in male mice (s.c.): 15.0 +/- 1.8 mg/kg (as 2-aminoindane HCL)
IN-VIVO
Scientific Literature
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