2-AMINOINDAN HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H11N.ClH
Molecular Weight	169.651
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.NC1CC2=CC=CC=C2C1

InChI

InChIKey=XEHNLVMHWYPNEQ-UHFFFAOYSA-N

InChI=1S/C9H11N.ClH/c10-9-5-7-3-1-2-4-8(7)6-9;/h1-4,9H,5-6,10H2;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C9H11N
Molecular Weight	133.1903
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
Alpha-2c adrenergic receptor 44 Target ID: CHEMBL1916 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940	Binding Agent 1076	41.0 nM [Ki]
Alpha-2b adrenergic receptor 35 Target ID: CHEMBL1942 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940	Binding Agent 1076	211.0 nM [Ki]
Alpha-2a adrenergic receptor 70 Target ID: CHEMBL1867 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940	Binding Agent 1076	134.0 nM [Ki]
Norepinephrine transporter 197 Target ID: CHEMBL222 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940	Substrate 661	86.0 nM [EC50]
Dopamine transporter 183 Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30904940	Substrate 661	439.0 nM [EC50]

PubMed

Title	Date	PubMed
Analgesic effect of Lepidium sativum Linn. (Chandrashura) in experimental animals.	2010-07	22131742
The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.	2010-05-13	20402514
The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline.	2010-03	20002521
Analgesic and anti-inflammatory activity of amifostine, DRDE-07, and their analogs, in mice.	2010-02	20606831
Synthesis and pharmacological evaluation of schiff bases of 4-(2-aminophenyl)-morpholines.	2009-07	20502549
[Analysis of designer drugs detected in the products purchased in fiscal year 2006].	2008-10	18827471
Synthesis, dopaminergic profile, and molecular dynamics calculations of N-aralkyl substituted 2-aminoindans.	2008-03-15	18166467
Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain.	2007-09	17786847
Conformations of 2-aminoindan in a supersonic jet: the role of intramolecular N-H...pi hydrogen bonding.	2007-07-12	17571864
Steady-state pharmacokinetics and pharmacodynamics of CHF3381, a novel antineuropathic pain agent, in healthy subjects.	2005-04	15801935
Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties.	2004-12-06	15501040
Safety, pharmacokinetics, and pharmacodynamics of CHF 3381, a novel N-methyl-D-aspartate antagonist, after single oral doses in healthy subjects.	2003-08	12953347
Copper-containing monooxygenases: enzymatic and biomimetic studies of the O-atom transfer catalysis.	2002-04	12069196

Patents

Substance Class	Chemical Created by `admin` on `Tue Apr 01 17:48:08 GMT 2025` Edited by `admin` on `Tue Apr 01 17:48:08 GMT 2025`
Record UNII	PT8MYB7QQ8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-AMINOINDAN HYDROCHLORIDE

Common Name

English

NSC-48663

Preferred Name

English

NSC-78117

Code

English

1H-INDEN-2-AMINE, 2,3-DIHYDRO-, HYDROCHLORIDE (1:1)

Systematic Name

English

2-INDANAMINE, HYDROCHLORIDE

Systematic Name

English

2-AI (HYDROCHLORIDE)

Common Name

English

INDAN-2-YLAMINE HYDROCHLORIDE

Systematic Name

English

2-AMINOINDAN, HCL

Common Name

English

Code System Code Type Description

ECHA (EC/EINECS)

219-048-0