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Details

Stereochemistry ACHIRAL
Molecular Formula C8H10ClN3S
Molecular Weight 215.7044
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIAMENIDINE

SMILES

Cc1csc(c1NC2=NCCN2)Cl

InChI

InChIKey=CVWILQHZFWRYPB-UHFFFAOYSA-N
InChI=1S/C8H10ClN3S/c1-5-4-13-7(9)6(5)12-8-10-2-3-11-8/h4H,2-3H2,1H3,(H2,10,11,12)

HIDE SMILES / InChI

Molecular Formula C8H10ClN3S
Molecular Weight 215.7044
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Tiamenidine (also known as HOE 440) is a diazacycloalkene derivative patented by Farbwerke Hoechst A.-G. as 2 alpha-sympathomimetic antihypertensive agents. In preclinical models, tiamenidine induces hypotension and bradycardia in renal hypertensive cats and rats and in normal rats and dogs. Furthermore, Tiamenidine inhibits the liberation of norepinephrine from nerves leading to the heart and suppress sympathetic circulatory reflexes in dogs. In clinical trials, Tiamenidine exerts favor influences on systolic and diastolic blood pressure, and reduces plasma noradrenaline and adrenaline levels and suppresses plasma renin activity. Unfortunately, during the withdrawal of Tiamenidine, there is a rebound of blood pressure and plasma noradrenaline and adrenaline, overshooting baseline levels.

Approval Year

PubMed

PubMed

TitleDatePubMed
Changes in blood pressure, heart rate, and sympathetic activity on abrupt withdrawal of tiamenidine (HOE 440) in essential hypertension.
1980 Nov
Withdrawal phenomena in subjects with essential hypertension on clonidine or tiamenidine.
1984 Nov
Withdrawal reactions following cessation of central alpha-adrenergic receptor agonists.
1984 Sep-Oct
Prediction of drug-target interaction networks from the integration of chemical and genomic spaces.
2008 Jul 1
Patents

Patents

Sample Use Guides

1-3mg for 1 year
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 14:40:42 UTC 2021
Edited
by admin
on Sat Jun 26 14:40:42 UTC 2021
Record UNII
195V08O55G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TIAMENIDINE
INN   MI   USAN   WHO-DD  
INN   USAN  
Official Name English
TIAMENIDINE [INN]
Common Name English
TIAMENIDINE [MI]
Common Name English
HOE-440
Code English
HOE 440
Code English
TIAMENIDINE [WHO-DD]
Common Name English
TIAMENIDINE [USAN]
Common Name English
SYMCOR BASE TTS
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C29709
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
Code System Code Type Description
CAS
31428-61-2
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
PRIMARY
MERCK INDEX
M10843
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
PRIMARY Merck Index
WIKIPEDIA
TIAMENIDINE
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
PRIMARY
MESH
C010354
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
PRIMARY
EVMPD
SUB11001MIG
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
PRIMARY
INN
3325
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
PRIMARY
ChEMBL
CHEMBL295409
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
PRIMARY
PUBCHEM
39974
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
PRIMARY
NCI_THESAURUS
C75046
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
PRIMARY
FDA UNII
195V08O55G
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
PRIMARY
EPA CompTox
31428-61-2
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
PRIMARY
DRUG CENTRAL
2649
Created by admin on Sat Jun 26 14:40:43 UTC 2021 , Edited by admin on Sat Jun 26 14:40:43 UTC 2021
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TARGET -> AGONIST
SHORT-ACTING
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY