U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C2H4O3
Molecular Weight 76.0514
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLYCOLIC ACID

SMILES

OCC(O)=O

InChI

InChIKey=AEMRFAOFKBGASW-UHFFFAOYSA-N
InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)

HIDE SMILES / InChI

Molecular Formula C2H4O3
Molecular Weight 76.0514
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

SODIUM GLYCOLATE, a sodium salt of carboxymethyl ether, is used as a pharmaceutical grade dissolution excipient for solid dosage forms. It absorbs water rapidly, resulting in swelling which leads to the rapid disintegration of tablets and capsules. Without a disintegrant, these may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEAR CELL SALICYLIC CLARIFYING TONIC

Approved Use

Prevention and treatment of Acne and acne-prone skin. A salicylic/glycolic acid skin clarifying removes excess surface oil. A blend of anti-oxidants leaves skin fresh and shine-free.

Launch Date

1.26230397E12
PubMed

PubMed

TitleDatePubMed
Simultaneous determination of ethylene glycol and glycolic acid in serum by gas chromatography-mass spectrometry.
1999 Nov-Dec
Intravenous nedaplatin and intraarterial cisplatin with transcatheter arterial embolization for patients with locally advanced uterine cervical cancer.
2001
The integration of paclitaxel and new platinum compounds in the treatment of advanced ovarian cancer.
2001
Molecular biology of the plastidic phosphorylated serine biosynthetic pathway in Arabidopsis thaliana.
2001
Cytocidal effect and DNA damage of nedaplatin in vitro by simulating pharmacokinetic parameters.
2001 Apr
The gene yghK linked to the glc operon of Escherichia coli encodes a permease for glycolate that is structurally and functionally similar to L-lactate permease.
2001 Apr
Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells.
2001 Apr
Iron coordination in photosystem II: interaction between bicarbonate and the QB pocket studied by Fourier transform infrared spectroscopy.
2001 Apr 3
Activity staining of isocitrate lyase after electrophoresis on either native or sodium dodecyl sulfate polyacrylamide gels.
2001 Aug
Ethylene glycol-mediated tubular injury: identification of critical metabolites and injury pathways.
2001 Aug
An easy screening method for fungi producing ochratoxin A in pure culture.
2001 Dec 30
Bioadhesive properties of hydroxypropylcellulose topical films produced by hot-melt extrusion.
2001 Feb 23
Preclinical in vivo antitumor efficacy of nedaplatin with gemcitabine against human lung cancer.
2001 Jan
Phenotypic expression of primary hyperoxaluria: comparative features of types I and II.
2001 Jan
Phase I/II study of intravenous nedaplatin and intraarterial cisplatin with transcatheter arterial embolization for patients with locally advanced uterine cervical carcinoma.
2001 Jan 1
[Concurrent chemoradiation therapy with nedaplatin for high-risk cervical cancer--clinical investigation of adverse events].
2001 Jul
[Targetting intra-arterial infusion chemotherapy with nedaplatin for oral cancer].
2001 Jul
[A case of esophageal carcinoma with multiple liver metastases successfully treated with nedaplatin (NDP) and 5-fluorouracil (5-FU) combined with radiotherapy].
2001 Jun
Reversal of cisplatin resistance by the 1,4-benzothiazepine derivative, JTV-519.
2001 Jun
[Concurrent chemoradiotherapy for advanced cervical cancer--a pilot study].
2001 Mar
Local structure analysis of Ti species stabilized in ion exchangeable layer solids by x-ray absorption spectroscopy.
2001 Mar 1
Surface modification of polyhydroxyalkanoate films and their interaction with human fibroblasts.
2001 Mar 14
Plant tissue-based chemiluminescence flow biosensor for glycolic acid.
2001 Mar 15
[Small cell carcinoma of the urinary bladder: a case report].
2001 Oct
Sequence-dependent antitumor efficacy of combination chemotherapy with nedaplatin, a newly developed platinum, and paclitaxel.
2001 Oct 22
Current and future potential roles of the platinum drugs in the treatment of ovarian cancer.
2001 Sep
Influence of adjuvants on the dissolution profile of tablets containing high doses of spray-dried extract of Maytenus ilicifolia.
2001 Sep
Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis.
2002 Apr 24
Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II.
2002 Aug
Phase I study of combination chemotherapy with 5-fluorouracil (5-FU) and nedaplatin (NDP): adverse effects and eecommended dose of NDP administered after 5-FU.
2002 Dec
[Current and future state of chemoradiotherapy for head and neck cancer].
2002 Feb
Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli.
2002 Jan 18
Epithelial ovarian cancer: second and third line chemotherapy (review).
2002 Jul
Chemical characterisation of sodium starch glycolate particles.
2002 Jun 20
An inherited metabolic disorder presenting as ethylene glycol intoxication in a young adult.
2002 Mar
[Combination chemotherapy with nedaplatin (CDGP) and 5-FU for oral cancer].
2002 Mar
Synthesis of a novel class of polyhydroxyalkanoates in Arabidopsis peroxisomes, and their use in monitoring short-chain-length intermediates of beta-oxidation.
2002 May
Sensitive and real-time determination of H2O2 release from intact peroxisomes.
2002 May 1
Genetic analysis--a diagnostic tool for primary hyperoxaluria type I.
2002 Nov
Irinotecan plus cisplatin has substantial antitumor effect as salvage chemotherapy against germ cell tumors.
2002 Nov 1
Carbon exchange in hot alkaline degradation of glucose.
2002 Nov 29
[Clinical study of the combination of small amount of nedaplatin (CDGP)/5-FU with radiation for the treatment of esophageal cancer].
2002 Oct
A formula for predicting optimal dosage of nedaplatin based on renal function in adult cancer patients.
2002 Sep
Patents
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:36:49 UTC 2023
Edited
by admin
on Wed Jul 05 22:36:49 UTC 2023
Record UNII
0WT12SX38S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLYCOLIC ACID
INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
GLYCOLIC ACID [MART.]
Common Name English
GLYCOLIC ACID [INCI]
Common Name English
Glycolic acid [WHO-DD]
Common Name English
2-HYDROXYACETIC ACID
Systematic Name English
GLYCOLIC ACID [VANDF]
Common Name English
GLYCOLIC ACID [MI]
Common Name English
NSC-166
Code English
HYDROXYETHANOIC ACID
Systematic Name English
HYDROXYACETIC ACID [HSDB]
Common Name English
GLYCOLATE
Systematic Name English
Classification Tree Code System Code
LOINC 2395-2
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 73883-1
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 25106-6
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 55864-3
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 13751-3
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 55865-0
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 54286-0
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 55863-5
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 20831-4
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 2396-0
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 73882-3
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
FDA ORPHAN DRUG 872422
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
EPA PESTICIDE CODE 101
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 78749-9
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 26682-5
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
LOINC 42502-5
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
Code System Code Type Description
PUBCHEM
757
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
NSC
166
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
DRUG BANK
DB03085
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
EVMPD
SUB23402
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
CONCEPT Industrial Aid
DRUG CENTRAL
4645
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
CHEBI
29805
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
EPA CompTox
DTXSID0025363
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
CAS
79-14-1
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
LACTMED
Glycolic Acid
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
SMS_ID
100000088717
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
RXCUI
70603
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
ALTERNATIVE
FDA UNII
0WT12SX38S
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
CHEBI
17497
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
RXCUI
587318
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
ECHA (EC/EINECS)
201-180-5
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
NCI_THESAURUS
C83737
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
HSDB
5227
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
MERCK INDEX
M5804
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY Merck Index
DAILYMED
0WT12SX38S
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
WIKIPEDIA
GLYCOLIC ACID
Created by admin on Wed Jul 05 22:36:49 UTC 2023 , Edited by admin on Wed Jul 05 22:36:49 UTC 2023
PRIMARY
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