U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C2H4O3
Molecular Weight 76.0514
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLYCOLIC ACID

SMILES

C(C(=O)O)O

InChI

InChIKey=AEMRFAOFKBGASW-UHFFFAOYSA-N
InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)

HIDE SMILES / InChI

Molecular Formula C2H4O3
Molecular Weight 76.0514
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

SODIUM GLYCOLATE, a sodium salt of carboxymethyl ether, is used as a pharmaceutical grade dissolution excipient for solid dosage forms. It absorbs water rapidly, resulting in swelling which leads to the rapid disintegration of tablets and capsules. Without a disintegrant, these may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEAR CELL SALICYLIC CLARIFYING TONIC

Approved Use

Prevention and treatment of Acne and acne-prone skin. A salicylic/glycolic acid skin clarifying removes excess surface oil. A blend of anti-oxidants leaves skin fresh and shine-free.

Launch Date

1.26230397E12
PubMed

PubMed

TitleDatePubMed
Intravenous nedaplatin and intraarterial cisplatin with transcatheter arterial embolization for patients with locally advanced uterine cervical cancer.
2001
Ethylene glycol toxicity: the role of serum glycolic acid in hemodialysis.
2001
An easy screening method for fungi producing ochratoxin A in pure culture.
2001 Dec 30
Pharmacokinetics and pharmacodynamics of serum platinum of gynecologic cancer patients treated with nedaplatin.
2001 Nov-Dec
[Small cell carcinoma of the urinary bladder: a case report].
2001 Oct
Sequence-dependent antitumor efficacy of combination chemotherapy with nedaplatin, a newly developed platinum, and paclitaxel.
2001 Oct 22
Current and future potential roles of the platinum drugs in the treatment of ovarian cancer.
2001 Sep
Small cell lung cancer: defining a role for emerging platinum drugs.
2002
Multiple sources of sodium starch glycolate, NF: evaluation of functional equivalence and development of standard performance tests.
2002
Action of carriers on Carbamazepine dissolution.
2002
Fast- and slow-release tablets for oral administration of flavonoids: rutin and quercetin.
2002 Apr
Global expression profiling of acetate-grown Escherichia coli.
2002 Apr 12
Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis.
2002 Apr 24
[A case of advanced esophageal cancer with multiple lymph node metastases successfully treated with induction chemotherapy consisting of nedaplatin and 5-FU followed by chemoradiotherapy].
2002 Aug
Phase I study of combination chemotherapy with 5-fluorouracil (5-FU) and nedaplatin (NDP): adverse effects and eecommended dose of NDP administered after 5-FU.
2002 Dec
Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures.
2002 Dec 13
[Current and future state of chemoradiotherapy for head and neck cancer].
2002 Feb
[Cloning and expression of spinach glycolate oxidase in Escherichia coli].
2002 Jan
Development of amperometric biosensors for the determination of glycolic acid in real samples.
2002 Jan 1
Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli.
2002 Jan 18
An aldol-based approach to the synthesis of the antibiotic anisomycin.
2002 Jan 24
Epithelial ovarian cancer: second and third line chemotherapy (review).
2002 Jul
Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.
2002 Jul 26
[Chemotherapy by superselective intraarterial infusion of nedaplatin combined with radiotherapy for oral cancer].
2002 Jun
Primary hyperoxaluria: a rare but important cause of nephrolithiasis.
2002 Jun
Particular aspects of platinum compounds used at present in cancer treatment.
2002 Jun
Chemical characterisation of sodium starch glycolate particles.
2002 Jun 20
Purification and characterization of malate synthase from the glucose-grown wood-rotting basidiomycete Fomitopsis palustris.
2002 Mar
An inherited metabolic disorder presenting as ethylene glycol intoxication in a young adult.
2002 Mar
[Combined preoperative therapy for oral cancer with nedaplatin and radiation].
2002 Mar
[Combination chemotherapy with nedaplatin (CDGP) and 5-FU for oral cancer].
2002 Mar
Glycine oxidase from Bacillus subtilis. Characterization of a new flavoprotein.
2002 Mar 1
[Chemoradiation therapy for esophageal cancer].
2002 May
Synthesis of a novel class of polyhydroxyalkanoates in Arabidopsis peroxisomes, and their use in monitoring short-chain-length intermediates of beta-oxidation.
2002 May
Sensitive and real-time determination of H2O2 release from intact peroxisomes.
2002 May 1
Asymmetric total synthesis of (-)-laulimalide: exploiting the asymmetric glycolate alkylation reaction.
2002 May 29
"Inverse sodium hydride": a crystalline salt that contains H(+) and Na(-).
2002 May 29
[Combination chemotherapy of paclitaxel followed by nedaplatin for human ovarian cancer].
2002 Nov
Metabolic shifts in hypersaline microbial mats upon addition of organic substrates.
2002 Nov
Genetic analysis--a diagnostic tool for primary hyperoxaluria type I.
2002 Nov
The combined effect of drought stress and heat shock on gene expression in tobacco.
2002 Nov
Irinotecan plus cisplatin has substantial antitumor effect as salvage chemotherapy against germ cell tumors.
2002 Nov 1
Carbon exchange in hot alkaline degradation of glucose.
2002 Nov 29
[Clinical study of the combination of small amount of nedaplatin (CDGP)/5-FU with radiation for the treatment of esophageal cancer].
2002 Oct
Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin with use of asymmetric anti- and syn-glycolate aldol reactions.
2002 Oct 3
Platinum drugs in the treatment of non-small-cell lung cancer.
2002 Oct 7
Powder compaction properties of sodium starch glycolate disintegrants.
2002 Sep
Evaluation of the effect of triterpenes on urinary risk factors of stone formation in pyridoxine deficient hyperoxaluric rats.
2002 Sep
Influence of excipients, drugs, and osmotic agent in the inner core on the time-controlled disintegration of compression-coated ethylcellulose tablets.
2002 Sep
A formula for predicting optimal dosage of nedaplatin based on renal function in adult cancer patients.
2002 Sep
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 16:34:48 UTC 2021
Edited
by admin
on Sat Jun 26 16:34:48 UTC 2021
Record UNII
0WT12SX38S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLYCOLIC ACID
INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
GLYCOLIC ACID [WHO-DD]
Common Name English
GLYCOLIC ACID [MART.]
Common Name English
GLYCOLIC ACID [INCI]
Common Name English
2-HYDROXYACETIC ACID
Systematic Name English
GLYCOLIC ACID [VANDF]
Common Name English
GLYCOLIC ACID [MI]
Common Name English
NSC-166
Code English
HYDROXYETHANOIC ACID
Systematic Name English
HYDROXYACETIC ACID [HSDB]
Common Name English
GLYCOLATE
Systematic Name English
Classification Tree Code System Code
LOINC 2395-2
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 73883-1
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 25106-6
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 55864-3
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 13751-3
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 55865-0
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 54286-0
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 55863-5
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 20831-4
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 2396-0
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 73882-3
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
EPA PESTICIDE CODE 101
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 78749-9
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 26682-5
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
LOINC 42502-5
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
Code System Code Type Description
PUBCHEM
757
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
DRUG BANK
DB03085
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
EVMPD
SUB23402
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
CONCEPT Industrial Aid
DRUG CENTRAL
4645
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
EPA CompTox
79-14-1
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
CAS
79-14-1
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
LACTMED
Glycolic Acid
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
RXCUI
70603
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
ALTERNATIVE
FDA UNII
0WT12SX38S
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
RXCUI
587318
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
ECHA (EC/EINECS)
201-180-5
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
NCI_THESAURUS
C83737
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
HSDB
5227
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
MERCK INDEX
M5804
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY Merck Index
WIKIPEDIA
GLYCOLIC ACID
Created by admin on Sat Jun 26 16:34:49 UTC 2021 , Edited by admin on Sat Jun 26 16:34:49 UTC 2021
PRIMARY
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SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY