U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C2H4O3
Molecular Weight 76.0514
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Glycolic Acid

SMILES

OCC(O)=O

InChI

InChIKey=AEMRFAOFKBGASW-UHFFFAOYSA-N
InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)

HIDE SMILES / InChI

Molecular Formula C2H4O3
Molecular Weight 76.0514
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

SODIUM GLYCOLATE, a sodium salt of carboxymethyl ether, is used as a pharmaceutical grade dissolution excipient for solid dosage forms. It absorbs water rapidly, resulting in swelling which leads to the rapid disintegration of tablets and capsules. Without a disintegrant, these may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEAR CELL SALICYLIC CLARIFYING TONIC

Approved Use

Prevention and treatment of Acne and acne-prone skin. A salicylic/glycolic acid skin clarifying removes excess surface oil. A blend of anti-oxidants leaves skin fresh and shine-free.

Launch Date

2009
PubMed

PubMed

TitleDatePubMed
Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures.
2002-12-13
Phase I study of combination chemotherapy with 5-fluorouracil (5-FU) and nedaplatin (NDP): adverse effects and eecommended dose of NDP administered after 5-FU.
2002-12
Carbon exchange in hot alkaline degradation of glucose.
2002-11-29
Irinotecan plus cisplatin has substantial antitumor effect as salvage chemotherapy against germ cell tumors.
2002-11-01
[Combination chemotherapy of paclitaxel followed by nedaplatin for human ovarian cancer].
2002-11
Metabolic shifts in hypersaline microbial mats upon addition of organic substrates.
2002-11
Genetic analysis--a diagnostic tool for primary hyperoxaluria type I.
2002-11
The combined effect of drought stress and heat shock on gene expression in tobacco.
2002-11
Platinum drugs in the treatment of non-small-cell lung cancer.
2002-10-07
Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin with use of asymmetric anti- and syn-glycolate aldol reactions.
2002-10-03
[Clinical study of the combination of small amount of nedaplatin (CDGP)/5-FU with radiation for the treatment of esophageal cancer].
2002-10
Irinotecan in patients with relapsed or cisplatin-refractory germ cell cancer: a phase II study of the German Testicular Cancer Study Group.
2002-09-23
Powder compaction properties of sodium starch glycolate disintegrants.
2002-09
Evaluation of the effect of triterpenes on urinary risk factors of stone formation in pyridoxine deficient hyperoxaluric rats.
2002-09
Influence of excipients, drugs, and osmotic agent in the inner core on the time-controlled disintegration of compression-coated ethylcellulose tablets.
2002-09
A formula for predicting optimal dosage of nedaplatin based on renal function in adult cancer patients.
2002-09
Repeated arthralgia associated with granulocyte colony stimulating factor administration.
2002-09
Preclinical combination chemotherapy of nedaplatin with gemcitabine against gemcitabine-refractory human lung cancer.
2002-08-08
[A case of advanced esophageal cancer with multiple lymph node metastases successfully treated with induction chemotherapy consisting of nedaplatin and 5-FU followed by chemoradiotherapy].
2002-08
Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II.
2002-08
Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.
2002-07-26
Structure of the complex of heptakis(2,6-di-O-methyl)-beta-cyclodextrin with (2,4-dichlorophenoxy)acetic acid.
2002-07-16
Proteomic analysis of leaf peroxisomal proteins in greening cotyledons of Arabidopsis thaliana.
2002-07
Epithelial ovarian cancer: second and third line chemotherapy (review).
2002-07
Chemical characterisation of sodium starch glycolate particles.
2002-06-20
Oxygen exchange in relation to carbon assimilation in water-stressed leaves during photosynthesis.
2002-06
Drought and oxidative load in the leaves of C3 plants: a predominant role for photorespiration?
2002-06
[Chemotherapy by superselective intraarterial infusion of nedaplatin combined with radiotherapy for oral cancer].
2002-06
Primary hyperoxaluria: a rare but important cause of nephrolithiasis.
2002-06
Particular aspects of platinum compounds used at present in cancer treatment.
2002-06
Asymmetric total synthesis of (-)-laulimalide: exploiting the asymmetric glycolate alkylation reaction.
2002-05-29
"Inverse sodium hydride": a crystalline salt that contains H(+) and Na(-).
2002-05-29
Sensitive and real-time determination of H2O2 release from intact peroxisomes.
2002-05-01
[Chemoradiation therapy for esophageal cancer].
2002-05
Synthesis of a novel class of polyhydroxyalkanoates in Arabidopsis peroxisomes, and their use in monitoring short-chain-length intermediates of beta-oxidation.
2002-05
Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis.
2002-04-24
Global expression profiling of acetate-grown Escherichia coli.
2002-04-12
Fast- and slow-release tablets for oral administration of flavonoids: rutin and quercetin.
2002-04
Purification and characterization of malate synthase from the glucose-grown wood-rotting basidiomycete Fomitopsis palustris.
2002-03
An inherited metabolic disorder presenting as ethylene glycol intoxication in a young adult.
2002-03
[Combined preoperative therapy for oral cancer with nedaplatin and radiation].
2002-03
[Combination chemotherapy with nedaplatin (CDGP) and 5-FU for oral cancer].
2002-03
[Current and future state of chemoradiotherapy for head and neck cancer].
2002-02
An aldol-based approach to the synthesis of the antibiotic anisomycin.
2002-01-24
Development of amperometric biosensors for the determination of glycolic acid in real samples.
2002-01-01
[Cloning and expression of spinach glycolate oxidase in Escherichia coli].
2002-01
Small cell lung cancer: defining a role for emerging platinum drugs.
2002
Multiple sources of sodium starch glycolate, NF: evaluation of functional equivalence and development of standard performance tests.
2002
Action of carriers on Carbamazepine dissolution.
2002
Intravenous nedaplatin and intraarterial cisplatin with transcatheter arterial embolization for patients with locally advanced uterine cervical cancer.
2001
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:45:39 GMT 2025
Edited
by admin
on Mon Mar 31 17:45:39 GMT 2025
Record UNII
0WT12SX38S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NSC-166
Preferred Name English
Glycolic Acid
INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
GLYCOLIC ACID [MART.]
Common Name English
Glycolic acid [WHO-DD]
Common Name English
2-HYDROXYACETIC ACID
Systematic Name English
GLYCOLIC ACID [VANDF]
Common Name English
GLYCOLIC ACID [MI]
Common Name English
HYDROXYETHANOIC ACID
Systematic Name English
HYDROXYACETIC ACID [HSDB]
Common Name English
GLYCOLATE
Systematic Name English
Classification Tree Code System Code
LOINC 2395-2
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 73883-1
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 25106-6
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 55864-3
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 13751-3
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 55865-0
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 54286-0
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 55863-5
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 20831-4
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 2396-0
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 73882-3
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
FDA ORPHAN DRUG 872422
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
EPA PESTICIDE CODE 101
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 78749-9
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 26682-5
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
LOINC 42502-5
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
Code System Code Type Description
PUBCHEM
757
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
NSC
166
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
DRUG BANK
DB03085
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
EVMPD
SUB23402
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
CONCEPT Industrial Aid
DRUG CENTRAL
4645
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
CHEBI
29805
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
EPA CompTox
DTXSID0025363
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
CAS
79-14-1
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
LACTMED
Glycolic Acid
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
SMS_ID
100000088717
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
RXCUI
70603
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
ALTERNATIVE
FDA UNII
0WT12SX38S
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
CHEBI
17497
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
RXCUI
587318
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
ECHA (EC/EINECS)
201-180-5
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
NCI_THESAURUS
C83737
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
HSDB
5227
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
MERCK INDEX
m5804
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY Merck Index
DAILYMED
0WT12SX38S
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
WIKIPEDIA
GLYCOLIC ACID
Created by admin on Mon Mar 31 17:45:40 GMT 2025 , Edited by admin on Mon Mar 31 17:45:40 GMT 2025
PRIMARY
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