Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H4O3 |
| Molecular Weight | 76.0514 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCC(O)=O
InChI
InChIKey=AEMRFAOFKBGASW-UHFFFAOYSA-N
InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)
| Molecular Formula | C2H4O3 |
| Molecular Weight | 76.0514 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
SODIUM GLYCOLATE, a sodium salt of carboxymethyl ether, is used as a pharmaceutical grade dissolution excipient for solid dosage forms. It absorbs water rapidly, resulting in swelling which leads to the rapid disintegration of tablets and capsules. Without a disintegrant, these may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | CLEAR CELL SALICYLIC CLARIFYING TONIC Approved UsePrevention and treatment of Acne and acne-prone skin. A salicylic/glycolic acid skin clarifying removes excess surface oil. A blend of anti-oxidants leaves skin fresh and shine-free. Launch Date2009 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Simultaneous determination of ethylene glycol and glycolic acid in serum by gas chromatography-mass spectrometry. | 1999 Nov-Dec |
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| Ethylene glycol toxicity: the role of serum glycolic acid in hemodialysis. | 2001 |
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| The integration of paclitaxel and new platinum compounds in the treatment of advanced ovarian cancer. | 2001 |
|
| Molecular biology of the plastidic phosphorylated serine biosynthetic pathway in Arabidopsis thaliana. | 2001 |
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| Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells. | 2001 Apr |
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| Activity staining of isocitrate lyase after electrophoresis on either native or sodium dodecyl sulfate polyacrylamide gels. | 2001 Aug |
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| Ethylene glycol-mediated tubular injury: identification of critical metabolites and injury pathways. | 2001 Aug |
|
| Structure of an active soluble mutant of the membrane-associated (S)-mandelate dehydrogenase. | 2001 Aug 21 |
|
| An easy screening method for fungi producing ochratoxin A in pure culture. | 2001 Dec 30 |
|
| In vitro synergistic interactions between the cisplatin analogue nedaplatin and the DNA topoisomerase I inhibitor irinotecan and the mechanism of this interaction. | 2001 Jan |
|
| Perturbation of rat renal tubule transport of the organic cation amantadine in recent onset streptozotocin-induced diabetes and in uninephrectomy. | 2001 Jan |
|
| Preclinical in vivo antitumor efficacy of nedaplatin with gemcitabine against human lung cancer. | 2001 Jan |
|
| Phenotypic expression of primary hyperoxaluria: comparative features of types I and II. | 2001 Jan |
|
| Synthesis of the left-hand portion of geldanamycin using an anti glycolate aldol reaction. | 2001 Jan 25 |
|
| [Concurrent chemoradiation therapy with nedaplatin for high-risk cervical cancer--clinical investigation of adverse events]. | 2001 Jul |
|
| [Targetting intra-arterial infusion chemotherapy with nedaplatin for oral cancer]. | 2001 Jul |
|
| [A case of esophageal carcinoma with multiple liver metastases successfully treated with nedaplatin (NDP) and 5-fluorouracil (5-FU) combined with radiotherapy]. | 2001 Jun |
|
| Reversal of cisplatin resistance by the 1,4-benzothiazepine derivative, JTV-519. | 2001 Jun |
|
| Transcriptional and posttranscriptional regulation of the glycolate oxidase gene in tobacco seedlings. | 2001 Mar |
|
| Local structure analysis of Ti species stabilized in ion exchangeable layer solids by x-ray absorption spectroscopy. | 2001 Mar 1 |
|
| Biochemical characterization of the 2-ketoacid reductases encoded by ycdW and yiaE genes in Escherichia coli. | 2001 Mar 15 |
|
| An aldol approach to the synthesis of the EF fragment of spongistatin 1. | 2001 Mar 22 |
|
| [Platinum compounds in cancer therapy--past, present, and future]. | 2001 May |
|
| [Small cell carcinoma of the urinary bladder: a case report]. | 2001 Oct |
|
| AGXT gene mutations and their influence on clinical heterogeneity of type 1 primary hyperoxaluria. | 2001 Oct |
|
| [A case of mandibular gingival cancer T4N0M0 which markedly responded to a combined therapy of nedaplatin with 5-fluorouracil]. | 2001 Sep |
|
| [Effect of combination chemotherapy with nedaplatin and 5-FU for head and neck squamous cell carcinoma]. | 2001 Sep |
|
| The catalytic role of tyrosine 254 in flavocytochrome b2 (L-lactate dehydrogenase from baker's yeast). Comparison between the Y254F and Y254L mutant proteins. | 2001 Sep |
|
| Effect of pharmacotechnical design on the in vitro interaction of ketoconazole tablets with non-systemic antacids. | 2001 Sep 11 |
|
| Action of carriers on Carbamazepine dissolution. | 2002 |
|
| Fast- and slow-release tablets for oral administration of flavonoids: rutin and quercetin. | 2002 Apr |
|
| [A case of advanced esophageal cancer with multiple lymph node metastases successfully treated with induction chemotherapy consisting of nedaplatin and 5-FU followed by chemoradiotherapy]. | 2002 Aug |
|
| Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II. | 2002 Aug |
|
| [Cloning and expression of spinach glycolate oxidase in Escherichia coli]. | 2002 Jan |
|
| Structure of the complex of heptakis(2,6-di-O-methyl)-beta-cyclodextrin with (2,4-dichlorophenoxy)acetic acid. | 2002 Jul 16 |
|
| Purification and characterization of malate synthase from the glucose-grown wood-rotting basidiomycete Fomitopsis palustris. | 2002 Mar |
|
| [Combination chemotherapy with nedaplatin (CDGP) and 5-FU for oral cancer]. | 2002 Mar |
|
| Sensitive and real-time determination of H2O2 release from intact peroxisomes. | 2002 May 1 |
|
| [Combination chemotherapy of paclitaxel followed by nedaplatin for human ovarian cancer]. | 2002 Nov |
|
| The combined effect of drought stress and heat shock on gene expression in tobacco. | 2002 Nov |
|
| Powder compaction properties of sodium starch glycolate disintegrants. | 2002 Sep |
|
| Influence of excipients, drugs, and osmotic agent in the inner core on the time-controlled disintegration of compression-coated ethylcellulose tablets. | 2002 Sep |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:04:41 GMT 2023
by
admin
on
Fri Dec 15 15:04:41 GMT 2023
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| Record UNII |
0WT12SX38S
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| Record Status |
Validated (UNII)
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| Record Version |
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2395-2
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55864-3
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13751-3
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55865-0
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54286-0
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55863-5
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20831-4
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2396-0
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73882-3
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FDA ORPHAN DRUG |
872422
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EPA PESTICIDE CODE |
101
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78749-9
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26682-5
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42502-5
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757
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166
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DB03085
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SUB23402
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C45678
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CONCEPT | Industrial Aid | ||
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4645
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29805
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DTXSID0025363
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79-14-1
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Glycolic Acid
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100000088717
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70603
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0WT12SX38S
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201-180-5
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C83737
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5227
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m5804
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0WT12SX38S
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GLYCOLIC ACID
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ACTIVE MOIETY |
