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Details

Stereochemistry ACHIRAL
Molecular Formula C2H3O3.Na
Molecular Weight 98.0332
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM GLYCOLATE

SMILES

[Na+].OCC([O-])=O

InChI

InChIKey=VILMUCRZVVVJCA-UHFFFAOYSA-M
InChI=1S/C2H4O3.Na/c3-1-2(4)5;/h3H,1H2,(H,4,5);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C2H3O3
Molecular Weight 75.0434
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

SODIUM GLYCOLATE, a sodium salt of carboxymethyl ether, is used as a pharmaceutical grade dissolution excipient for solid dosage forms. It absorbs water rapidly, resulting in swelling which leads to the rapid disintegration of tablets and capsules. Without a disintegrant, these may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEAR CELL SALICYLIC CLARIFYING TONIC

Approved Use

Prevention and treatment of Acne and acne-prone skin. A salicylic/glycolic acid skin clarifying removes excess surface oil. A blend of anti-oxidants leaves skin fresh and shine-free.

Launch Date

1.26230397E12
PubMed

PubMed

TitleDatePubMed
Intravenous nedaplatin and intraarterial cisplatin with transcatheter arterial embolization for patients with locally advanced uterine cervical cancer.
2001
Molecular biology of the plastidic phosphorylated serine biosynthetic pathway in Arabidopsis thaliana.
2001
Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells.
2001 Apr
Perturbation of rat renal tubule transport of the organic cation amantadine in recent onset streptozotocin-induced diabetes and in uninephrectomy.
2001 Jan
Synthesis of the left-hand portion of geldanamycin using an anti glycolate aldol reaction.
2001 Jan 25
[Concurrent chemoradiation therapy with nedaplatin for high-risk cervical cancer--clinical investigation of adverse events].
2001 Jul
Transcriptional and posttranscriptional regulation of the glycolate oxidase gene in tobacco seedlings.
2001 Mar
Biochemical characterization of the 2-ketoacid reductases encoded by ycdW and yiaE genes in Escherichia coli.
2001 Mar 15
An aldol approach to the synthesis of the EF fragment of spongistatin 1.
2001 Mar 22
Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin.
2001 May
[Small cell carcinoma of the urinary bladder: a case report].
2001 Oct
Current and future potential roles of the platinum drugs in the treatment of ovarian cancer.
2001 Sep
Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis.
2002 Apr 24
[A case of advanced esophageal cancer with multiple lymph node metastases successfully treated with induction chemotherapy consisting of nedaplatin and 5-FU followed by chemoradiotherapy].
2002 Aug
Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II.
2002 Aug
Phase I study of combination chemotherapy with 5-fluorouracil (5-FU) and nedaplatin (NDP): adverse effects and eecommended dose of NDP administered after 5-FU.
2002 Dec
Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures.
2002 Dec 13
Drought and oxidative load in the leaves of C3 plants: a predominant role for photorespiration?
2002 Jun
Purification and characterization of malate synthase from the glucose-grown wood-rotting basidiomycete Fomitopsis palustris.
2002 Mar
Synthesis of a novel class of polyhydroxyalkanoates in Arabidopsis peroxisomes, and their use in monitoring short-chain-length intermediates of beta-oxidation.
2002 May
Sensitive and real-time determination of H2O2 release from intact peroxisomes.
2002 May 1
"Inverse sodium hydride": a crystalline salt that contains H(+) and Na(-).
2002 May 29
[Combination chemotherapy of paclitaxel followed by nedaplatin for human ovarian cancer].
2002 Nov
Genetic analysis--a diagnostic tool for primary hyperoxaluria type I.
2002 Nov
The combined effect of drought stress and heat shock on gene expression in tobacco.
2002 Nov
Irinotecan plus cisplatin has substantial antitumor effect as salvage chemotherapy against germ cell tumors.
2002 Nov 1
Carbon exchange in hot alkaline degradation of glucose.
2002 Nov 29
Powder compaction properties of sodium starch glycolate disintegrants.
2002 Sep
Evaluation of the effect of triterpenes on urinary risk factors of stone formation in pyridoxine deficient hyperoxaluric rats.
2002 Sep
Influence of excipients, drugs, and osmotic agent in the inner core on the time-controlled disintegration of compression-coated ethylcellulose tablets.
2002 Sep
Repeated arthralgia associated with granulocyte colony stimulating factor administration.
2002 Sep
Irinotecan in patients with relapsed or cisplatin-refractory germ cell cancer: a phase II study of the German Testicular Cancer Study Group.
2002 Sep 23
Patents
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:24:10 UTC 2023
Edited
by admin
on Wed Jul 05 23:24:10 UTC 2023
Record UNII
B75E535IMI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM GLYCOLATE
INCI  
INCI  
Official Name English
GLYCOLIC ACID, MONOSODIUM SALT
Common Name English
SODIUM GLYCOLATE [INCI]
Common Name English
SODIUM HYDROXYACETATE
Systematic Name English
SODIUM 2-HYDROXYACETATE
Systematic Name English
SODIUM GLYCOLLATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C78284
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
EPA PESTICIDE CODE 103
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
Code System Code Type Description
MESH
C031149
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
PRIMARY
RXCUI
1356762
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID6047153
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
PRIMARY
ECHA (EC/EINECS)
220-624-9
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
PRIMARY
PUBCHEM
517347
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
PRIMARY
DAILYMED
B75E535IMI
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
PRIMARY
SMS_ID
100000129315
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
PRIMARY
CAS
2836-32-0
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
PRIMARY
FDA UNII
B75E535IMI
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
PRIMARY
NCI_THESAURUS
C84158
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
PRIMARY
EVMPD
SUB38237
Created by admin on Wed Jul 05 23:24:10 UTC 2023 , Edited by admin on Wed Jul 05 23:24:10 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE