SODIUM GLYCOLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H3O3.Na
Molecular Weight	98.0332
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].OCC([O-])=O

InChI

InChIKey=VILMUCRZVVVJCA-UHFFFAOYSA-M

InChI=1S/C2H4O3.Na/c3-1-2(4)5;/h3H,1H2,(H,4,5);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C2H3O3
Molecular Weight	75.0434
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/inactive/sodium-glycolate-476.html | https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=b0c23a2c-b250-4c0d-9b2a-c1483faa2ca0&type=display

SODIUM GLYCOLATE, a sodium salt of carboxymethyl ether, is used as a pharmaceutical grade dissolution excipient for solid dosage forms. It absorbs water rapidly, resulting in swelling which leads to the rapid disintegration of tablets and capsules. Without a disintegrant, these may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Acne 98 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=82790140-8251-40a4-bfdc-084a62e1d94b	Preventing		Not Provided 504	CLEAR CELL SALICYLIC CLARIFYING TONIC Approved Use Prevention and treatment of Acne and acne-prone skin. A salicylic/glycolic acid skin clarifying removes excess surface oil. A blend of anti-oxidants leaves skin fresh and shine-free. Launch Date 1.26230397E12

PubMed

Title	Date	PubMed
Ethylene glycol toxicity: the role of serum glycolic acid in hemodialysis.	2001	11762669
The integration of paclitaxel and new platinum compounds in the treatment of advanced ovarian cancer.	2001	11488999
[Tissue platinum distribution and the effect following intra-arterial injection of cisplatin to metastatic liver cancer--a case report].	2001 Aug	11525035
Synthesis of the left-hand portion of geldanamycin using an anti glycolate aldol reaction.	2001 Jan 25	11430049
[Targetting intra-arterial infusion chemotherapy with nedaplatin for oral cancer].	2001 Jul	11478134
[Concurrent chemoradiotherapy for advanced cervical cancer--a pilot study].	2001 Mar	11265403
Plant tissue-based chemiluminescence flow biosensor for glycolic acid.	2001 Mar 15	11305652
Biochemical characterization of the 2-ketoacid reductases encoded by ycdW and yiaE genes in Escherichia coli.	2001 Mar 15	11237876
Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin.	2001 May	11359487
Peroxisomal targeting of mammalian hydroxyacid oxidase 1 requires the C-terminal tripeptide SKI.	2001 May	11309194
Sequence-dependent antitumor efficacy of combination chemotherapy with nedaplatin, a newly developed platinum, and paclitaxel.	2001 Oct 22	11595125
[A case of mandibular gingival cancer T4N0M0 which markedly responded to a combined therapy of nedaplatin with 5-fluorouracil].	2001 Sep	11579639
A dynamic study and modeling of the formation of polyhydroxyalkanoates combined with treatment of high strength wastewater.	2001 Sep 1	11563668
Global expression profiling of acetate-grown Escherichia coli.	2002 Apr 12	11815613
Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis.	2002 Apr 24	11960423
Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II.	2002 Aug	12110000
Preclinical combination chemotherapy of nedaplatin with gemcitabine against gemcitabine-refractory human lung cancer.	2002 Aug 8	12175524
Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli.	2002 Jan 18	11785976
Epithelial ovarian cancer: second and third line chemotherapy (review).	2002 Jul	12063566
Primary hyperoxaluria: a rare but important cause of nephrolithiasis.	2002 Jun	12055367
[Combination chemotherapy with nedaplatin (CDGP) and 5-FU for oral cancer].	2002 Mar	11915732
Asymmetric total synthesis of (-)-laulimalide: exploiting the asymmetric glycolate alkylation reaction.	2002 May 29	12022826
"Inverse sodium hydride": a crystalline salt that contains H(+) and Na(-).	2002 May 29	12022811
Genetic analysis--a diagnostic tool for primary hyperoxaluria type I.	2002 Nov	12432429
Evaluation of the effect of triterpenes on urinary risk factors of stone formation in pyridoxine deficient hyperoxaluric rats.	2002 Sep	12237806
Influence of excipients, drugs, and osmotic agent in the inner core on the time-controlled disintegration of compression-coated ethylcellulose tablets.	2002 Sep	12210050
A formula for predicting optimal dosage of nedaplatin based on renal function in adult cancer patients.	2002 Sep	12203105

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:55:53 UTC 2023` Edited by `admin` on `Fri Dec 15 15:55:53 UTC 2023`
Record UNII	B75E535IMI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM GLYCOLATE

Official Name

English

GLYCOLIC ACID, MONOSODIUM SALT

Common Name

English

SODIUM GLYCOLATE [INCI]

Common Name

English

SODIUM HYDROXYACETATE

Systematic Name

English

SODIUM 2-HYDROXYACETATE

Systematic Name

English

SODIUM GLYCOLLATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78284