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Details

Stereochemistry ACHIRAL
Molecular Formula C2H3O3.Na
Molecular Weight 98.0332
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM GLYCOLATE

SMILES

[Na+].OCC([O-])=O

InChI

InChIKey=VILMUCRZVVVJCA-UHFFFAOYSA-M
InChI=1S/C2H4O3.Na/c3-1-2(4)5;/h3H,1H2,(H,4,5);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C2H3O3
Molecular Weight 75.0434
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

SODIUM GLYCOLATE, a sodium salt of carboxymethyl ether, is used as a pharmaceutical grade dissolution excipient for solid dosage forms. It absorbs water rapidly, resulting in swelling which leads to the rapid disintegration of tablets and capsules. Without a disintegrant, these may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEAR CELL SALICYLIC CLARIFYING TONIC

Approved Use

Prevention and treatment of Acne and acne-prone skin. A salicylic/glycolic acid skin clarifying removes excess surface oil. A blend of anti-oxidants leaves skin fresh and shine-free.

Launch Date

2009
PubMed

PubMed

TitleDatePubMed
Simultaneous determination of ethylene glycol and glycolic acid in serum by gas chromatography-mass spectrometry.
1999 Nov-Dec
Activity staining of isocitrate lyase after electrophoresis on either native or sodium dodecyl sulfate polyacrylamide gels.
2001 Aug
Synthesis of the left-hand portion of geldanamycin using an anti glycolate aldol reaction.
2001 Jan 25
[A case of esophageal carcinoma with multiple liver metastases successfully treated with nedaplatin (NDP) and 5-fluorouracil (5-FU) combined with radiotherapy].
2001 Jun
Reversal of cisplatin resistance by the 1,4-benzothiazepine derivative, JTV-519.
2001 Jun
Biodegradable microspheres of novel segmented poly(ether-ester-amide)s based on poly(epsilon-caprolactone) for the delivery of bioactive compounds.
2001 Jun
[Concurrent chemoradiotherapy for advanced cervical cancer--a pilot study].
2001 Mar
Plant tissue-based chemiluminescence flow biosensor for glycolic acid.
2001 Mar 15
Current and future potential roles of the platinum drugs in the treatment of ovarian cancer.
2001 Sep
Effect of pharmacotechnical design on the in vitro interaction of ketoconazole tablets with non-systemic antacids.
2001 Sep 11
[A case of advanced esophageal cancer with multiple lymph node metastases successfully treated with induction chemotherapy consisting of nedaplatin and 5-FU followed by chemoradiotherapy].
2002 Aug
Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II.
2002 Aug
Phase I study of combination chemotherapy with 5-fluorouracil (5-FU) and nedaplatin (NDP): adverse effects and eecommended dose of NDP administered after 5-FU.
2002 Dec
[Cloning and expression of spinach glycolate oxidase in Escherichia coli].
2002 Jan
Development of amperometric biosensors for the determination of glycolic acid in real samples.
2002 Jan 1
Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli.
2002 Jan 18
Structure of the complex of heptakis(2,6-di-O-methyl)-beta-cyclodextrin with (2,4-dichlorophenoxy)acetic acid.
2002 Jul 16
Particular aspects of platinum compounds used at present in cancer treatment.
2002 Jun
An inherited metabolic disorder presenting as ethylene glycol intoxication in a young adult.
2002 Mar
[Combined preoperative therapy for oral cancer with nedaplatin and radiation].
2002 Mar
Glycine oxidase from Bacillus subtilis. Characterization of a new flavoprotein.
2002 Mar 1
"Inverse sodium hydride": a crystalline salt that contains H(+) and Na(-).
2002 May 29
Genetic analysis--a diagnostic tool for primary hyperoxaluria type I.
2002 Nov
Carbon exchange in hot alkaline degradation of glucose.
2002 Nov 29
Influence of excipients, drugs, and osmotic agent in the inner core on the time-controlled disintegration of compression-coated ethylcellulose tablets.
2002 Sep
A formula for predicting optimal dosage of nedaplatin based on renal function in adult cancer patients.
2002 Sep
Repeated arthralgia associated with granulocyte colony stimulating factor administration.
2002 Sep
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:55:53 GMT 2023
Edited
by admin
on Fri Dec 15 15:55:53 GMT 2023
Record UNII
B75E535IMI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM GLYCOLATE
INCI  
INCI  
Official Name English
GLYCOLIC ACID, MONOSODIUM SALT
Common Name English
SODIUM GLYCOLATE [INCI]
Common Name English
SODIUM HYDROXYACETATE
Systematic Name English
SODIUM 2-HYDROXYACETATE
Systematic Name English
SODIUM GLYCOLLATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C78284
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
EPA PESTICIDE CODE 103
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
Code System Code Type Description
MESH
C031149
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
PRIMARY
RXCUI
1356762
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID6047153
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
PRIMARY
ECHA (EC/EINECS)
220-624-9
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
PRIMARY
PUBCHEM
517347
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
PRIMARY
DAILYMED
B75E535IMI
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
PRIMARY
SMS_ID
100000129315
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
PRIMARY
CAS
2836-32-0
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
PRIMARY
FDA UNII
B75E535IMI
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
PRIMARY
NCI_THESAURUS
C84158
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
PRIMARY
EVMPD
SUB38237
Created by admin on Fri Dec 15 15:55:53 GMT 2023 , Edited by admin on Fri Dec 15 15:55:53 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE