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Details

Stereochemistry ACHIRAL
Molecular Formula C2H3O3.Na
Molecular Weight 98.0332
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM GLYCOLATE

SMILES

[Na+].OCC([O-])=O

InChI

InChIKey=VILMUCRZVVVJCA-UHFFFAOYSA-M
InChI=1S/C2H4O3.Na/c3-1-2(4)5;/h3H,1H2,(H,4,5);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C2H3O3
Molecular Weight 75.0434
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

SODIUM GLYCOLATE, a sodium salt of carboxymethyl ether, is used as a pharmaceutical grade dissolution excipient for solid dosage forms. It absorbs water rapidly, resulting in swelling which leads to the rapid disintegration of tablets and capsules. Without a disintegrant, these may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEAR CELL SALICYLIC CLARIFYING TONIC

Approved Use

Prevention and treatment of Acne and acne-prone skin. A salicylic/glycolic acid skin clarifying removes excess surface oil. A blend of anti-oxidants leaves skin fresh and shine-free.

Launch Date

1.26230397E12
PubMed

PubMed

TitleDatePubMed
Intravenous nedaplatin and intraarterial cisplatin with transcatheter arterial embolization for patients with locally advanced uterine cervical cancer.
2001
The integration of paclitaxel and new platinum compounds in the treatment of advanced ovarian cancer.
2001
The gene yghK linked to the glc operon of Escherichia coli encodes a permease for glycolate that is structurally and functionally similar to L-lactate permease.
2001 Apr
Iron coordination in photosystem II: interaction between bicarbonate and the QB pocket studied by Fourier transform infrared spectroscopy.
2001 Apr 3
[Evaluation of a combination chemotherapy with nedaplatin and 5-FU for oral cancers].
2001 Aug
Structure of an active soluble mutant of the membrane-associated (S)-mandelate dehydrogenase.
2001 Aug 21
Preclinical in vivo antitumor efficacy of nedaplatin with gemcitabine against human lung cancer.
2001 Jan
Cytocidal effect and DNA damage of nedaplatin: a mathematical model and analysis of experimental data.
2001 Mar
Local structure analysis of Ti species stabilized in ion exchangeable layer solids by x-ray absorption spectroscopy.
2001 Mar 1
Plant tissue-based chemiluminescence flow biosensor for glycolic acid.
2001 Mar 15
An aldol approach to the synthesis of the EF fragment of spongistatin 1.
2001 Mar 22
[Platinum compounds in cancer therapy--past, present, and future].
2001 May
Peroxisomal targeting of mammalian hydroxyacid oxidase 1 requires the C-terminal tripeptide SKI.
2001 May
The catalytic role of tyrosine 254 in flavocytochrome b2 (L-lactate dehydrogenase from baker's yeast). Comparison between the Y254F and Y254L mutant proteins.
2001 Sep
Effect of pharmacotechnical design on the in vitro interaction of ketoconazole tablets with non-systemic antacids.
2001 Sep 11
Multiple sources of sodium starch glycolate, NF: evaluation of functional equivalence and development of standard performance tests.
2002
Action of carriers on Carbamazepine dissolution.
2002
Fast- and slow-release tablets for oral administration of flavonoids: rutin and quercetin.
2002 Apr
[A case of advanced esophageal cancer with multiple lymph node metastases successfully treated with induction chemotherapy consisting of nedaplatin and 5-FU followed by chemoradiotherapy].
2002 Aug
Preclinical combination chemotherapy of nedaplatin with gemcitabine against gemcitabine-refractory human lung cancer.
2002 Aug 8
Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures.
2002 Dec 13
[Current and future state of chemoradiotherapy for head and neck cancer].
2002 Feb
[Cloning and expression of spinach glycolate oxidase in Escherichia coli].
2002 Jan
An aldol-based approach to the synthesis of the antibiotic anisomycin.
2002 Jan 24
Proteomic analysis of leaf peroxisomal proteins in greening cotyledons of Arabidopsis thaliana.
2002 Jul
Epithelial ovarian cancer: second and third line chemotherapy (review).
2002 Jul
Structure of the complex of heptakis(2,6-di-O-methyl)-beta-cyclodextrin with (2,4-dichlorophenoxy)acetic acid.
2002 Jul 16
Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.
2002 Jul 26
Oxygen exchange in relation to carbon assimilation in water-stressed leaves during photosynthesis.
2002 Jun
Chemical characterisation of sodium starch glycolate particles.
2002 Jun 20
Purification and characterization of malate synthase from the glucose-grown wood-rotting basidiomycete Fomitopsis palustris.
2002 Mar
An inherited metabolic disorder presenting as ethylene glycol intoxication in a young adult.
2002 Mar
[Combined preoperative therapy for oral cancer with nedaplatin and radiation].
2002 Mar
[Combination chemotherapy with nedaplatin (CDGP) and 5-FU for oral cancer].
2002 Mar
Synthesis of a novel class of polyhydroxyalkanoates in Arabidopsis peroxisomes, and their use in monitoring short-chain-length intermediates of beta-oxidation.
2002 May
Sensitive and real-time determination of H2O2 release from intact peroxisomes.
2002 May 1
Asymmetric total synthesis of (-)-laulimalide: exploiting the asymmetric glycolate alkylation reaction.
2002 May 29
"Inverse sodium hydride": a crystalline salt that contains H(+) and Na(-).
2002 May 29
[Combination chemotherapy of paclitaxel followed by nedaplatin for human ovarian cancer].
2002 Nov
Metabolic shifts in hypersaline microbial mats upon addition of organic substrates.
2002 Nov
Genetic analysis--a diagnostic tool for primary hyperoxaluria type I.
2002 Nov
Carbon exchange in hot alkaline degradation of glucose.
2002 Nov 29
Influence of excipients, drugs, and osmotic agent in the inner core on the time-controlled disintegration of compression-coated ethylcellulose tablets.
2002 Sep
A formula for predicting optimal dosage of nedaplatin based on renal function in adult cancer patients.
2002 Sep
Repeated arthralgia associated with granulocyte colony stimulating factor administration.
2002 Sep
Irinotecan in patients with relapsed or cisplatin-refractory germ cell cancer: a phase II study of the German Testicular Cancer Study Group.
2002 Sep 23
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 16 18:40:27 UTC 2022
Edited
by admin
on Fri Dec 16 18:40:27 UTC 2022
Record UNII
B75E535IMI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM GLYCOLATE
INCI  
INCI  
Official Name English
GLYCOLIC ACID, MONOSODIUM SALT
Common Name English
SODIUM GLYCOLATE [INCI]
Common Name English
SODIUM HYDROXYACETATE
Systematic Name English
SODIUM 2-HYDROXYACETATE
Systematic Name English
SODIUM GLYCOLLATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C78284
Created by admin on Fri Dec 16 18:40:27 UTC 2022 , Edited by admin on Fri Dec 16 18:40:27 UTC 2022
EPA PESTICIDE CODE 103
Created by admin on Fri Dec 16 18:40:27 UTC 2022 , Edited by admin on Fri Dec 16 18:40:27 UTC 2022
Code System Code Type Description
MESH
C031149
Created by admin on Fri Dec 16 18:40:27 UTC 2022 , Edited by admin on Fri Dec 16 18:40:27 UTC 2022
PRIMARY
RXCUI
1356762
Created by admin on Fri Dec 16 18:40:27 UTC 2022 , Edited by admin on Fri Dec 16 18:40:27 UTC 2022
PRIMARY RxNorm
EPA CompTox
DTXSID6047153
Created by admin on Fri Dec 16 18:40:27 UTC 2022 , Edited by admin on Fri Dec 16 18:40:27 UTC 2022
PRIMARY
ECHA (EC/EINECS)
220-624-9
Created by admin on Fri Dec 16 18:40:27 UTC 2022 , Edited by admin on Fri Dec 16 18:40:27 UTC 2022
PRIMARY
PUBCHEM
517347
Created by admin on Fri Dec 16 18:40:27 UTC 2022 , Edited by admin on Fri Dec 16 18:40:27 UTC 2022
PRIMARY
DAILYMED
B75E535IMI
Created by admin on Fri Dec 16 18:40:27 UTC 2022 , Edited by admin on Fri Dec 16 18:40:27 UTC 2022
PRIMARY
CAS
2836-32-0
Created by admin on Fri Dec 16 18:40:27 UTC 2022 , Edited by admin on Fri Dec 16 18:40:27 UTC 2022
PRIMARY
FDA UNII
B75E535IMI
Created by admin on Fri Dec 16 18:40:27 UTC 2022 , Edited by admin on Fri Dec 16 18:40:27 UTC 2022
PRIMARY
NCI_THESAURUS
C84158
Created by admin on Fri Dec 16 18:40:27 UTC 2022 , Edited by admin on Fri Dec 16 18:40:27 UTC 2022
PRIMARY
EVMPD
SUB38237
Created by admin on Fri Dec 16 18:40:27 UTC 2022 , Edited by admin on Fri Dec 16 18:40:27 UTC 2022
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE