U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C2H3O3.H4N
Molecular Weight 93.0819
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMMONIUM GLYCOLATE

SMILES

[NH4+].OCC([O-])=O

InChI

InChIKey=UBKBVPONTPMQQW-UHFFFAOYSA-N
InChI=1S/C2H4O3.H3N/c3-1-2(4)5;/h3H,1H2,(H,4,5);1H3

HIDE SMILES / InChI

Molecular Formula C2H4O3
Molecular Weight 76.0514
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H3N
Molecular Weight 17.0305
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

SODIUM GLYCOLATE, a sodium salt of carboxymethyl ether, is used as a pharmaceutical grade dissolution excipient for solid dosage forms. It absorbs water rapidly, resulting in swelling which leads to the rapid disintegration of tablets and capsules. Without a disintegrant, these may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEAR CELL SALICYLIC CLARIFYING TONIC

Approved Use

Prevention and treatment of Acne and acne-prone skin. A salicylic/glycolic acid skin clarifying removes excess surface oil. A blend of anti-oxidants leaves skin fresh and shine-free.

Launch Date

1.26230397E12
PubMed

PubMed

TitleDatePubMed
Simultaneous determination of ethylene glycol and glycolic acid in serum by gas chromatography-mass spectrometry.
1999 Nov-Dec
Evaluation of the functional equivalence of crospovidone NF from different sources. I. Physical characterization.
2001
Cytocidal effect and DNA damage of nedaplatin in vitro by simulating pharmacokinetic parameters.
2001 Apr
The gene yghK linked to the glc operon of Escherichia coli encodes a permease for glycolate that is structurally and functionally similar to L-lactate permease.
2001 Apr
Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells.
2001 Apr
Iron coordination in photosystem II: interaction between bicarbonate and the QB pocket studied by Fourier transform infrared spectroscopy.
2001 Apr 3
Activity staining of isocitrate lyase after electrophoresis on either native or sodium dodecyl sulfate polyacrylamide gels.
2001 Aug
An easy screening method for fungi producing ochratoxin A in pure culture.
2001 Dec 30
Bioadhesive properties of hydroxypropylcellulose topical films produced by hot-melt extrusion.
2001 Feb 23
Perturbation of rat renal tubule transport of the organic cation amantadine in recent onset streptozotocin-induced diabetes and in uninephrectomy.
2001 Jan
Preclinical in vivo antitumor efficacy of nedaplatin with gemcitabine against human lung cancer.
2001 Jan
Phenotypic expression of primary hyperoxaluria: comparative features of types I and II.
2001 Jan
Phase I/II study of intravenous nedaplatin and intraarterial cisplatin with transcatheter arterial embolization for patients with locally advanced uterine cervical carcinoma.
2001 Jan 1
[A case of esophageal carcinoma with multiple liver metastases successfully treated with nedaplatin (NDP) and 5-fluorouracil (5-FU) combined with radiotherapy].
2001 Jun
Biodegradable microspheres of novel segmented poly(ether-ester-amide)s based on poly(epsilon-caprolactone) for the delivery of bioactive compounds.
2001 Jun
[Concurrent chemoradiotherapy for advanced cervical cancer--a pilot study].
2001 Mar
Biochemical characterization of the 2-ketoacid reductases encoded by ycdW and yiaE genes in Escherichia coli.
2001 Mar 15
Pharmacokinetics and pharmacodynamics of serum platinum of gynecologic cancer patients treated with nedaplatin.
2001 Nov-Dec
[Small cell carcinoma of the urinary bladder: a case report].
2001 Oct
AGXT gene mutations and their influence on clinical heterogeneity of type 1 primary hyperoxaluria.
2001 Oct
Multiple sources of sodium starch glycolate, NF: evaluation of functional equivalence and development of standard performance tests.
2002
Global expression profiling of acetate-grown Escherichia coli.
2002 Apr 12
Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis.
2002 Apr 24
Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II.
2002 Aug
Phase I study of combination chemotherapy with 5-fluorouracil (5-FU) and nedaplatin (NDP): adverse effects and eecommended dose of NDP administered after 5-FU.
2002 Dec
Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures.
2002 Dec 13
Primary hyperoxaluria: a rare but important cause of nephrolithiasis.
2002 Jun
An inherited metabolic disorder presenting as ethylene glycol intoxication in a young adult.
2002 Mar
[Chemoradiation therapy for esophageal cancer].
2002 May
[Combination chemotherapy of paclitaxel followed by nedaplatin for human ovarian cancer].
2002 Nov
Metabolic shifts in hypersaline microbial mats upon addition of organic substrates.
2002 Nov
Genetic analysis--a diagnostic tool for primary hyperoxaluria type I.
2002 Nov
The combined effect of drought stress and heat shock on gene expression in tobacco.
2002 Nov
Irinotecan plus cisplatin has substantial antitumor effect as salvage chemotherapy against germ cell tumors.
2002 Nov 1
Carbon exchange in hot alkaline degradation of glucose.
2002 Nov 29
[Clinical study of the combination of small amount of nedaplatin (CDGP)/5-FU with radiation for the treatment of esophageal cancer].
2002 Oct
Platinum drugs in the treatment of non-small-cell lung cancer.
2002 Oct 7
Powder compaction properties of sodium starch glycolate disintegrants.
2002 Sep
Patents
Substance Class Chemical
Created
by admin
on Thu Jul 06 03:16:23 UTC 2023
Edited
by admin
on Thu Jul 06 03:16:23 UTC 2023
Record UNII
8G1X5P7GIL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMMONIUM GLYCOLATE
INCI  
INCI  
Official Name English
ACETIC ACID, 2-HYDROXY-, AMMONIUM SALT (1:1)
Common Name English
ACETIC ACID, HYDROXY-, MONOAMMONIUM SALT
Common Name English
AMMONIUM HYDROXYACETATE
Systematic Name English
AMMONIUM GLYCOLATE [INCI]
Common Name English
HYDROXYACETIC ACID AMMONIUM SALT
Common Name English
GLICONOL L
Common Name English
Code System Code Type Description
FDA UNII
8G1X5P7GIL
Created by admin on Thu Jul 06 03:16:23 UTC 2023 , Edited by admin on Thu Jul 06 03:16:23 UTC 2023
PRIMARY
CAS
35249-89-9
Created by admin on Thu Jul 06 03:16:23 UTC 2023 , Edited by admin on Thu Jul 06 03:16:23 UTC 2023
PRIMARY
PUBCHEM
169677
Created by admin on Thu Jul 06 03:16:23 UTC 2023 , Edited by admin on Thu Jul 06 03:16:23 UTC 2023
PRIMARY
EPA CompTox
DTXSID6049642
Created by admin on Thu Jul 06 03:16:23 UTC 2023 , Edited by admin on Thu Jul 06 03:16:23 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY