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Details

Stereochemistry ACHIRAL
Molecular Formula C2H3O3.H4N
Molecular Weight 93.0819
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMMONIUM GLYCOLATE

SMILES

[NH4+].OCC([O-])=O

InChI

InChIKey=UBKBVPONTPMQQW-UHFFFAOYSA-N
InChI=1S/C2H4O3.H3N/c3-1-2(4)5;/h3H,1H2,(H,4,5);1H3

HIDE SMILES / InChI

Molecular Formula C2H4O3
Molecular Weight 76.0514
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H3N
Molecular Weight 17.0305
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

SODIUM GLYCOLATE, a sodium salt of carboxymethyl ether, is used as a pharmaceutical grade dissolution excipient for solid dosage forms. It absorbs water rapidly, resulting in swelling which leads to the rapid disintegration of tablets and capsules. Without a disintegrant, these may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEAR CELL SALICYLIC CLARIFYING TONIC

Approved Use

Prevention and treatment of Acne and acne-prone skin. A salicylic/glycolic acid skin clarifying removes excess surface oil. A blend of anti-oxidants leaves skin fresh and shine-free.

Launch Date

1.26230397E12
PubMed

PubMed

TitleDatePubMed
Intravenous nedaplatin and intraarterial cisplatin with transcatheter arterial embolization for patients with locally advanced uterine cervical cancer.
2001
Ethylene glycol toxicity: the role of serum glycolic acid in hemodialysis.
2001
Evaluation of the functional equivalence of crospovidone NF from different sources. I. Physical characterization.
2001
The gene yghK linked to the glc operon of Escherichia coli encodes a permease for glycolate that is structurally and functionally similar to L-lactate permease.
2001 Apr
Iron coordination in photosystem II: interaction between bicarbonate and the QB pocket studied by Fourier transform infrared spectroscopy.
2001 Apr 3
An easy screening method for fungi producing ochratoxin A in pure culture.
2001 Dec 30
[Targetting intra-arterial infusion chemotherapy with nedaplatin for oral cancer].
2001 Jul
Cytocidal effect and DNA damage of nedaplatin: a mathematical model and analysis of experimental data.
2001 Mar
Local structure analysis of Ti species stabilized in ion exchangeable layer solids by x-ray absorption spectroscopy.
2001 Mar 1
Surface modification of polyhydroxyalkanoate films and their interaction with human fibroblasts.
2001 Mar 14
Sequence-dependent antitumor efficacy of combination chemotherapy with nedaplatin, a newly developed platinum, and paclitaxel.
2001 Oct 22
Current and future potential roles of the platinum drugs in the treatment of ovarian cancer.
2001 Sep
Influence of adjuvants on the dissolution profile of tablets containing high doses of spray-dried extract of Maytenus ilicifolia.
2001 Sep
The catalytic role of tyrosine 254 in flavocytochrome b2 (L-lactate dehydrogenase from baker's yeast). Comparison between the Y254F and Y254L mutant proteins.
2001 Sep
Small cell lung cancer: defining a role for emerging platinum drugs.
2002
Multiple sources of sodium starch glycolate, NF: evaluation of functional equivalence and development of standard performance tests.
2002
Action of carriers on Carbamazepine dissolution.
2002
Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis.
2002 Apr 24
Preclinical combination chemotherapy of nedaplatin with gemcitabine against gemcitabine-refractory human lung cancer.
2002 Aug 8
Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.
2002 Jul 26
Drought and oxidative load in the leaves of C3 plants: a predominant role for photorespiration?
2002 Jun
[Chemotherapy by superselective intraarterial infusion of nedaplatin combined with radiotherapy for oral cancer].
2002 Jun
Particular aspects of platinum compounds used at present in cancer treatment.
2002 Jun
Purification and characterization of malate synthase from the glucose-grown wood-rotting basidiomycete Fomitopsis palustris.
2002 Mar
An inherited metabolic disorder presenting as ethylene glycol intoxication in a young adult.
2002 Mar
[Combined preoperative therapy for oral cancer with nedaplatin and radiation].
2002 Mar
Glycine oxidase from Bacillus subtilis. Characterization of a new flavoprotein.
2002 Mar 1
Synthesis of a novel class of polyhydroxyalkanoates in Arabidopsis peroxisomes, and their use in monitoring short-chain-length intermediates of beta-oxidation.
2002 May
[Combination chemotherapy of paclitaxel followed by nedaplatin for human ovarian cancer].
2002 Nov
Genetic analysis--a diagnostic tool for primary hyperoxaluria type I.
2002 Nov
Evaluation of the effect of triterpenes on urinary risk factors of stone formation in pyridoxine deficient hyperoxaluric rats.
2002 Sep
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 17 04:45:38 UTC 2022
Edited
by admin
on Sat Dec 17 04:45:38 UTC 2022
Record UNII
8G1X5P7GIL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMMONIUM GLYCOLATE
INCI  
INCI  
Official Name English
ACETIC ACID, 2-HYDROXY-, AMMONIUM SALT (1:1)
Common Name English
ACETIC ACID, HYDROXY-, MONOAMMONIUM SALT
Common Name English
AMMONIUM HYDROXYACETATE
Systematic Name English
AMMONIUM GLYCOLATE [INCI]
Common Name English
HYDROXYACETIC ACID AMMONIUM SALT
Common Name English
GLICONOL L
Common Name English
Code System Code Type Description
FDA UNII
8G1X5P7GIL
Created by admin on Sat Dec 17 04:45:38 UTC 2022 , Edited by admin on Sat Dec 17 04:45:38 UTC 2022
PRIMARY
CAS
35249-89-9
Created by admin on Sat Dec 17 04:45:38 UTC 2022 , Edited by admin on Sat Dec 17 04:45:38 UTC 2022
PRIMARY
PUBCHEM
169677
Created by admin on Sat Dec 17 04:45:38 UTC 2022 , Edited by admin on Sat Dec 17 04:45:38 UTC 2022
PRIMARY
EPA CompTox
DTXSID6049642
Created by admin on Sat Dec 17 04:45:38 UTC 2022 , Edited by admin on Sat Dec 17 04:45:38 UTC 2022
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY