Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H28O2 |
Molecular Weight | 228.3709 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCC(O)=O
InChI
InChIKey=TUNFSRHWOTWDNC-UHFFFAOYSA-N
InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)
Molecular Formula | C14H28O2 |
Molecular Weight | 228.3709 |
Charge | 0 |
Count |
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Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ewg.org/skindeep/ingredient/706137/SODIUM_MYRISTATE/ | Burdock, G.A. (1997) Encyclopedia of Food and Color Additives, page 2575, retrieved from: https://books.google.ru/books?id=NtaR9i3hYCYC | Igoe, R.S. (2013) Dictionary of Food Ingredients, page 129, retrieved from: https://books.google.ru/books?id=WEKEBwAAQBAJhttps://www.ncbi.nlm.nih.gov/pubmed/9323584 | https://elibrary.ru/item.asp?id=5420911 | http://www.tuscany-diet.net/lipids/list-of-fatty-acids/myristic/ | https://www.ncbi.nlm.nih.gov/pubmed/19154695 | https://www.ncbi.nlm.nih.gov/pubmed/20634506DOI: 10.1016/0378-5173(89)90003-3
Sources: https://www.ewg.org/skindeep/ingredient/706137/SODIUM_MYRISTATE/ | Burdock, G.A. (1997) Encyclopedia of Food and Color Additives, page 2575, retrieved from: https://books.google.ru/books?id=NtaR9i3hYCYC | Igoe, R.S. (2013) Dictionary of Food Ingredients, page 129, retrieved from: https://books.google.ru/books?id=WEKEBwAAQBAJhttps://www.ncbi.nlm.nih.gov/pubmed/9323584 | https://elibrary.ru/item.asp?id=5420911 | http://www.tuscany-diet.net/lipids/list-of-fatty-acids/myristic/ | https://www.ncbi.nlm.nih.gov/pubmed/19154695 | https://www.ncbi.nlm.nih.gov/pubmed/20634506DOI: 10.1016/0378-5173(89)90003-3
Ammonium myristate is passage-delaying substance. It was used as a substance for influencing gastrointestinal passage. The addition of ammonium myristate caused a delay of about 1.5 h in the transit time of the absorbing part of the gastrointestinal tract. The addition of ammonium myristate improves the availability of nitrofurantoin from a slow releasing dosage form - an average increase is 23.8% of the total amount of nitrofurantoin excreted in the urine compared to the values obtained from the reference dosage form without the additional substance. The kinetics of renal elimination of nitrofurantoin is characterized by the longer duration of urinary excretion.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3335863
Curator's Comment: Known to be CNS penetrant in rats. Human data not available.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL5088 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20920594 |
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Target ID: CHEMBL2021749 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20920594 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Diagnostic | Unknown Approved UseUnknown |
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Sources: https://www.ncbi.nlm.nih.gov/pubmed/26800189 |
Diagnostic | Unknown Approved UseUnknown |
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Inactive ingredient | Volu-Firm Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Influence of a fatty acid on duodenal motility. | 1975 |
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Activation of guinea pig polymorphonuclear leukocytes with soluble stimulators leads to nonrandom distribution of NADPH oxidase in the plasma membrane. | 1983 Sep |
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The effect of additives on the oral mucosal absorption of human calcitonin in rats. | 1988 Jun |
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The mitigating effects of phosphatidylcholines on bile salt- and lysophosphatidylcholine-induced membrane damage. | 1992 Aug |
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Study on the lifetime and attenuation properties of microbubbles coated with carboxylic acid salts. | 2000 Nov |
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Comparative quantitative fatty acid analysis of triacylglycerols using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and gas chromatography. | 2001 |
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Longitudinal study of fatty acids in plasma and erythrocyte phospholipids during pregnancy. | 2001 |
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Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels. | 2001 |
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Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery. | 2001 Aug |
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A new double coupling system: synthesis of citronellyl acetate via transacetylation to citronellol from acetyl coenzyme A produced from glucose and free fatty acids. | 2001 Aug |
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Biosynthesis and structural characterization of medium-chain-length poly(3-hydroxyalkanoates) produced by Pseudomonas aeruginosa from fatty acids. | 2001 Aug 20 |
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Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis. | 2001 Aug 7 |
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Regulation of Golgi structure and function by ARF-like protein 1 (Arl1). | 2001 Dec |
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Palmitate decreases proton pumping of liver-type cytochrome c oxidase. | 2001 Dec |
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Characterization of the binding of Photobacterium phosphoreum P-flavin by Vibrio harveyi Luciferase. | 2001 Dec 15 |
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[Determination of higher fatty acids in human plasma]. | 2001 Jul |
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Molecular characterization of StCDPK1, a calcium-dependent protein kinase from Solanum tuberosum that is induced at the onset of tuber development. | 2001 Jul |
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N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons. | 2001 Jun |
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Expression, purification and characterization of cytochrome P450 Biol: a novel P450 involved in biotin synthesis in Bacillus subtilis. | 2001 Jun |
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Fatty acid profiles of nitrite-oxidizing bacteria reflect their phylogenetic heterogeneity. | 2001 Nov |
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Inhibition and regulation of rat liver L-threonine dehydrogenase by different fatty acids and their derivatives. | 2001 Nov 7 |
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Enzyme activity of the cytochrome P-450 monooxygenase system in the presence of single chain lipid molecules. | 2001 Nov-Dec |
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Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells. | 2001 Oct |
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Effects of incubator humidity and hen age on yolk composition in broiler hatching eggs from young breeders. | 2001 Oct |
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Ethanol- and nicotine-induced membrane changes in embryonic and neonatal chick brains. | 2001 Oct |
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Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation. | 2001 Oct 1 |
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Site-directed mutagenesis of the putative distal helix of peroxygenase cytochrome P450. | 2001 Oct 1 |
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Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members. | 2001 Oct 19 |
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The biology and enzymology of protein N-myristoylation. | 2001 Oct 26 |
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Rational design of diflunisal analogues with reduced affinity for human serum albumin. | 2001 Oct 31 |
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Propranolol increases phosphatidic acid level via activation of phospholipase D. | 2001 Sep |
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Rat pancreatic acinar cells express a cytosolic phospholipase D1b isoform that is not regulated by cholecystokinin. | 2001 Sep |
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Optimization of carbohydrate fatty acid ester synthesis in organic media by a lipase from Candida antarctica. | 2001 Sep 20 |
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Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids. | 2001 Sep 28 |
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Coexpression of proteins with methionine aminopeptidase and/or N-myristoyltransferase in Escherichia coli to increase acylation and homogeneity of protein preparations. | 2002 |
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Myristyl and palmityl acylation of pI 5.1 carboxylesterase from porcine intestine and liver. | 2002 Feb |
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Differences in the fatty acid composition of larvae and metamorphosing sea lampreys, Petromyzon marinus. | 2002 Feb |
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Oxidative stress induced cytokine production in isolated rat pancreatic acinar cells: effects of small-molecule antioxidants. | 2002 Feb |
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Serum free fatty acid pattern and risk of myocardial infarction: a case-control study. | 2002 Jan |
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[Fatty acid-induced reversal of general anesthesia: chain length-dependence of antagonizing potencies of fatty acids]. | 2002 Jan |
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Differences in calmodulin and calmodulin-binding proteins in phasic and tonic smooth muscles. | 2002 Jan |
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Permeation of a myristoylated dipeptide across the buccal mucosa: topological distribution and evaluation of tissue integrity. | 2002 Jan 1 |
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Interaction of bovine (BSA) and human (HSA) serum albumins with ionic surfactants: spectroscopy and modelling. | 2002 Jan 31 |
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The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase. | 2002 Jan 4 |
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Adsorption and direct probing of fibrinogen and sodium myristate at the air/water interface. | 2002 Jun 15 |
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Solubility of sodium soaps in aqueous salt solutions. | 2005 Nov 15 |
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Mechanisms of competitive adsorption of albumin and sodium myristate at the silicon oxide/aqueous interface. | 2005 Oct 25 |
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Single-step purification of myristoylated and nonmyristoylated recoverin and substrate dependence of myristoylation level. | 2006 Feb 1 |
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Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli. | 2008 Oct |
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Self assembly of anastomosis-like superstructures in fatty acid/guanidine hydrochloride aqueous dispersions. | 2010 Jan 15 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 16 16:00:30 UTC 2022
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Fri Dec 16 16:00:30 UTC 2022
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Record UNII |
0I3V7S25AW
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Record Status |
Validated (UNII)
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NCI_THESAURUS |
C68421
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CFR |
21 CFR 172.860
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NCI_THESAURUS |
C68388
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LOINC |
75103-2
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CFR |
21 CFR 357.210
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LOINC |
35157-7
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JECFA EVALUATION |
MYRISTIC ACID
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LOINC |
47783-6
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DSLD |
3280 (Number of products:15)
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SUB128589
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11005
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M7689
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544-63-8
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1356758
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DTXSID6021666
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DB08231
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1448990
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30807
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CHEMBL111077
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28875
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0I3V7S25AW
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D019814
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MYRISTIC ACID
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C68393
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5028
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208-875-2
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0I3V7S25AW
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1313976
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ALTERNATIVE | |||
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5686
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |
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LIPID -> FATTY ACID |
G Jurriens and ACJ Kroesen, J Am Oil Chem Soc, 42(9)(1965)(average value).
Range values as of FAO/WHO Codex Alimentarius Committee on commercial fats and oils.(unspecified percent)
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |
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LIPID -> FATTY ACID |
U.S produced rice oil. Values are % of composition.
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LIPID -> FATTY ACID |
JB Rossell and co-workers; JAOCS62(2), 221-230(1985).
Range weight is a mean.
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SALT/SOLVATE -> PARENT | |||
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LIPID -> FATTY ACID |
Values are % of total.
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LIPID -> FATTY ACID |
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PARENT -> CONSTITUENT ALWAYS PRESENT |
USP
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SALT/SOLVATE -> PARENT | |||
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LIPID -> FATTY ACID |
MAY BE PRESENT
USP
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LIPID -> FATTY ACID |
Values given are in undefined precent.
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SALT/SOLVATE -> PARENT |
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LIPID -> FATTY ACID |
Values are % of weight of fatty acid composition.
O?Connor, RT, Herb, SF; J Am Oil Chem Soc 47, 186A, 195A, 197A(1970)(range)
Brignoli, CA et al: J Am Diet Assoc 68, 224(1976)(average
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |
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PARENT -> CONSTITUENT ALWAYS PRESENT |
USP
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
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