SODIUM MYRISTATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H27O2.Na
Molecular Weight	250.3527
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].CCCCCCCCCCCCCC([O-])=O

InChI

InChIKey=JUQGWKYSEXPRGL-UHFFFAOYSA-M

InChI=1S/C14H28O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16;/h2-13H2,1H3,(H,15,16);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C14H27O2
Molecular Weight	227.363
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9323584 | https://elibrary.ru/item.asp?id=5420911 | http://www.tuscany-diet.net/lipids/list-of-fatty-acids/myristic/ | https://www.ncbi.nlm.nih.gov/pubmed/19154695 | https://www.ncbi.nlm.nih.gov/pubmed/20634506DOI: 10.1016/0378-5173(89)90003-3https://www.ewg.org/skindeep/ingredient/706137/SODIUM_MYRISTATE/ | Burdock, G.A. (1997) Encyclopedia of Food and Color Additives, page 2575, retrieved from: https://books.google.ru/books?id=NtaR9i3hYCYC | Igoe, R.S. (2013) Dictionary of Food Ingredients, page 129, retrieved from: https://books.google.ru/books?id=WEKEBwAAQBAJ

Sodium myristate is the sodium salt of myristic acid. It is used in the food as the binder, emulsifier and anticaking agent. It is one of the commonly occurring soaps. It is used in cosmetic as a cleansing and emulsifying agent.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Fatty acid desaturase 2 9 Target ID: CHEMBL5088 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20920594	Activator 1447
Sphingolipid delta(4)-desaturase DES1 5 Target ID: CHEMBL2021749 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20920594	Activator 1447

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2596
Gallbladder cancer 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7745974	Diagnostic	Not Provided 511	Unknown Approved Use Unknown
Sepsis 74 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26800189	Diagnostic	Phase II 1147	Unknown Approved Use Unknown
Sunburns 22 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a8276be2-93f1-4782-b206-93ea31036216	Inactive ingredient	Approved 8583	Volu-Firm Approved Use Unknown

PubMed

Title	Date	PubMed
The mitigating effects of phosphatidylcholines on bile salt- and lysophosphatidylcholine-induced membrane damage.	1992 Aug	1359088
Thermodynamics of binding water and solute to powdered long-chain salts of fatty acids.	1994 Oct	7851944
Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha.	1999 Jul 14	10403814
Evaluation of skin damage caused by percutaneous absorption enhancers using fractal analysis.	2000 Apr	10737917
Study on the lifetime and attenuation properties of microbubbles coated with carboxylic acid salts.	2000 Nov	11106009
Effect of Protonation on the Solution and Phase Behavior of Aqueous Sodium Myristate.	2000 Nov 1	11082246
Longitudinal study of fatty acids in plasma and erythrocyte phospholipids during pregnancy.	2001	11565197
Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels.	2001	11560763
Final report on the safety assessment of Cocoyl Sarcosine, Lauroyl Sarcosine, Myristoyl Sarcosine, Oleoyl Sarcosine, Stearoyl Sarcosine, Sodium Cocoyl Sarcosinate, Sodium Lauroyl Sarcosinate, Sodium Myristoyl Sarcosinate, Ammonium Cocoyl Sarcosinate, and Ammonium Lauroyl Sarcosinate.	2001	11358107
Effects of authentic and VLDL hydrolysis-derived fatty acids on vascular smooth muscle cell growth.	2001 Apr	11309244
Carotenoid esters in vegetables and fruits: a screening with emphasis on beta-cryptoxanthin esters.	2001 Apr	11308368
Thioacylation is required for targeting G-protein subunit G(o1alpha) to detergent-insoluble caveolin-containing membrane domains.	2001 Apr 15	11284718
Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery.	2001 Aug	11685899
Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells.	2001 Aug	11424085
Biosynthesis and structural characterization of medium-chain-length poly(3-hydroxyalkanoates) produced by Pseudomonas aeruginosa from fatty acids.	2001 Aug 20	11518582
Overexpression of the myristoylated alanine-rich C-kinase substrate inhibits cell adhesion to extracellular matrix components.	2001 Aug 24	11413143
Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis.	2001 Aug 7	11478885
Characterization of the binding of Photobacterium phosphoreum P-flavin by Vibrio harveyi Luciferase.	2001 Dec 15	11747297
Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.	2001 Feb 23	11063746
The neuronal calcium sensor family of Ca2+-binding proteins.	2001 Jan 1	11115393
Characterization of a new member of the fatty acid-binding protein family that binds all-trans-retinol.	2001 Jan 12	11022035
The kinetic and spectral characterization of the E. coli-expressed mammalian CYP4A7: cytochrome b5 effects vary with substrate.	2001 Jan 15	11368012
Drosophila embryos lacking N-myristoyltransferase have multiple developmental defects.	2001 Jan 15	11139338
Influence of myristoylation, phosphorylation, and deamidation on the structural behavior of the N-terminus of the catalytic subunit of cAMP-dependent protein kinase.	2001 Jan 9	11141074
[Determination of higher fatty acids in human plasma].	2001 Jul	11530524
Molecular characterization of StCDPK1, a calcium-dependent protein kinase from Solanum tuberosum that is induced at the onset of tuber development.	2001 Jul	11516152
Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands.	2001 Jul 6	11312268
N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons.	2001 Jun	11493554
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.	2001 Jun	11421736
Imidazoline I(1) receptor-induced activation of phosphatidylcholine-specific phospholipase C elicits mitogen-activated protein kinase phosphorylation in PC12 cells.	2001 Mar	11274989
Regulation of G proteins by covalent modification.	2001 Mar 26	11313912
N-terminal myristylation of HBV preS1 domain enhances receptor recognition.	2001 May	11350599
Ca(2+)- and myristoylation-dependent association of calcineurin with phosphatidylserine.	2001 May	11328609
Morbid myristoylation.	2001 May	11316594
A fluorogenic reagent, 4-mercapto-7-methylthio-2,1,3-benzoxadiazole for carboxylic acids, designed by prediction of the fluorescence intensity.	2001 May 15	11393836
Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.	2001 May 29	11371195
Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells.	2001 Oct	11606024
Effects of incubator humidity and hen age on yolk composition in broiler hatching eggs from young breeders.	2001 Oct	11599703
Ethanol- and nicotine-induced membrane changes in embryonic and neonatal chick brains.	2001 Oct	11574286
Site-directed mutagenesis of the putative distal helix of peroxygenase cytochrome P450.	2001 Oct 1	11566026
The biology and enzymology of protein N-myristoylation.	2001 Oct 26	11527981
Rational design of diflunisal analogues with reduced affinity for human serum albumin.	2001 Oct 31	11673972
Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14).	2001 Sep 14	11451957
Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids.	2001 Sep 28	11566289
[Fatty acid-induced reversal of general anesthesia: chain length-dependence of antagonizing potencies of fatty acids].	2002 Jan	11840655
Adsorption and direct probing of fibrinogen and sodium myristate at the air/water interface.	2002 Jun 15	16290663
Single-step purification of myristoylated and nonmyristoylated recoverin and substrate dependence of myristoylation level.	2006 Feb 1	16376289
Self assembly of anastomosis-like superstructures in fatty acid/guanidine hydrochloride aqueous dispersions.	2010 Jan 15	19879592

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Rous sarcoma virus-transformed cells were labeled for 2 h with either 1 mCi of [3H]palmitic acid or 0.2 mCi of [3H]myristic acid, and p60src was isolated by immunoprecipitation. The incorporation of [3H]myristic acid into p60src was ca. 100-fold greater than the incorporation of [3H]palmitic acid.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:31:37 GMT 2025` Edited by `admin` on `Mon Mar 31 19:31:37 GMT 2025`
Record UNII	06BLC4V0IV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM MYRISTATE

Official Name

English

C 14-98/100MY, SODIUM SALT

Preferred Name

English

MYRISTIC ACID, SODIUM SALT

Common Name

English

E-470(I)MYRISTIC ACID, SODIUM SALT

Common Name

English

TETRADECANOIC ACID, SODIUM SALT

Common Name

English

INS NO.470(I)MYRISTIC ACID, SODIUM SALT

Common Name

English

NIKKOL MK 140

Common Name

English

INS-470(I)MYRISTIC ACID, SODIUM SALT

Common Name

English

Classification Tree Code System Code

JECFA EVALUATION

INS-470(I)