U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C14H27O2.Na
Molecular Weight 250.3527
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM MYRISTATE

SMILES

[Na+].CCCCCCCCCCCCCC([O-])=O

InChI

InChIKey=JUQGWKYSEXPRGL-UHFFFAOYSA-M
InChI=1S/C14H28O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16;/h2-13H2,1H3,(H,15,16);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C14H27O2
Molecular Weight 227.363
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Ammonium myristate is passage-delaying substance. It was used as a substance for influencing gastrointestinal passage. The addition of ammonium myristate caused a delay of about 1.5 h in the transit time of the absorbing part of the gastrointestinal tract. The addition of ammonium myristate improves the availability of nitrofurantoin from a slow releasing dosage form - an average increase is 23.8% of the total amount of nitrofurantoin excreted in the urine compared to the values obtained from the reference dosage form without the additional substance. The kinetics of renal elimination of nitrofurantoin is characterized by the longer duration of urinary excretion.

CNS Activity

Curator's Comment: Known to be CNS penetrant in rats. Human data not available.

Originator

Sources: DOI: 10.1080/14786444108650255

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Unknown

Approved Use

Unknown
Diagnostic
Unknown

Approved Use

Unknown
Inactive ingredient
Volu-Firm

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Permeation kinetics of ketotifen fumarate alone and in combination with hydrophobic permeation enhancers through human cadaver epidermis.
2000 Jul-Aug
Molecular cloning, genomic organization, and biochemical characterization of myristoyl-CoA:protein N-myristoyltransferase from Arabidopsis thaliana.
2000 Mar 31
Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels.
2001
In vitro production of peroxynitrite by haemocytes from marine bivalves: C-ELISA determination of 3-nitrotyrosine level in plasma proteins from Mytilus galloprovincialis and Crassostrea gigas.
2001
Functional analysis of ADP-ribosylation factor (ARF) guanine nucleotide exchange factors Gea1p and Gea2p in yeast.
2001
Isolation and properties of GRP1, an ADP-ribosylation factor (ARF)-guanine nucleotide exchange protein regulated by phosphatidylinositol 3,4,5-trisphosphate.
2001
Expression, purification, and biochemical properties of EFA6, a Sec7 domain-containing guanine exchange factor for ADP-ribosylation factor 6 (ARF6).
2001
Effects of authentic and VLDL hydrolysis-derived fatty acids on vascular smooth muscle cell growth.
2001 Apr
Carotenoid esters in vegetables and fruits: a screening with emphasis on beta-cryptoxanthin esters.
2001 Apr
Myristoylation of human immunodeficiency virus type 1 gag protein is required for efficient env protein transportation to the surface of cells.
2001 Apr 20
Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography.
2001 Apr 27
Flunitrazepam, a 7-nitro-1,4-benzodiazepine that is unable to bind to the indole-benzodiazepine site of human serum albumin.
2001 Apr 7
Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery.
2001 Aug
Palmitate decreases proton pumping of liver-type cytochrome c oxidase.
2001 Dec
Isolation and structural characterization of an R-form lipopolysaccharide from Yersinia enterocolitica serotype O:8.
2001 Feb
Differential actions of PKA and PKC in the regulation of glutamate release by group III mGluRs in the entorhinal cortex.
2001 Feb
Cellular and viral Fos proteins are degraded by different proteolytic systems.
2001 Feb 22
Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.
2001 Feb 23
Intraterminal Ca(2+) and spontaneous transmitter release at the frog neuromuscular junction.
2001 Jan
Behenic acid is a cholesterol-raising saturated fatty acid in humans.
2001 Jan
Relationship between the concentrations of plasma phospholipid stearic acid and plasma lipoprotein lipids in healthy men.
2001 Jan
The neuronal calcium sensor family of Ca2+-binding proteins.
2001 Jan 1
Characterization of a new member of the fatty acid-binding protein family that binds all-trans-retinol.
2001 Jan 12
Interaction between the unphosphorylated receptor with high affinity for IgE and Lyn kinase.
2001 Jan 12
Drosophila embryos lacking N-myristoyltransferase have multiple developmental defects.
2001 Jan 15
Influence of myristoylation, phosphorylation, and deamidation on the structural behavior of the N-terminus of the catalytic subunit of cAMP-dependent protein kinase.
2001 Jan 9
Fatty acid remodeling of glycosyl phosphatidylinositol anchors in Trypanosoma brucei: incorporation of fatty acids other than myristate.
2001 Jul
Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands.
2001 Jul 6
N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons.
2001 Jun
Differential mechanisms of glucose and palmitate in augmentation of insulin secretion in mouse pancreatic islets.
2001 Jun
Imidazoline I(1) receptor-induced activation of phosphatidylcholine-specific phospholipase C elicits mitogen-activated protein kinase phosphorylation in PC12 cells.
2001 Mar
Crystallographic phasing of myristoyl-CoA-protein N-myristoyltransferase using an iodinated analog of myristoyl-CoA.
2001 Mar
Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization.
2001 Mar 1
Regulation of G proteins by covalent modification.
2001 Mar 26
Role of rapsyn tetratricopeptide repeat and coiled-coil domains in self-association and nicotinic acetylcholine receptor clustering.
2001 Mar 9
The effect of temperature on the fatty acids and isozymes of a psychrotrophic and two mesophilic species of Xenorhabdus, a bacterial symbiont of entomopathogenic nematodes.
2001 May
Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.
2001 May 29
Fatty acid profiles of nitrite-oxidizing bacteria reflect their phylogenetic heterogeneity.
2001 Nov
Inhibition and regulation of rat liver L-threonine dehydrogenase by different fatty acids and their derivatives.
2001 Nov 7
Enzyme activity of the cytochrome P-450 monooxygenase system in the presence of single chain lipid molecules.
2001 Nov-Dec
The biology and enzymology of protein N-myristoylation.
2001 Oct 26
Rational design of diflunisal analogues with reduced affinity for human serum albumin.
2001 Oct 31
Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction.
2002 Apr 19
Myristoylated alanine-rich C kinase substrate (MARCKS) sequesters spin-labeled phosphatidylinositol 4,5-bisphosphate in lipid bilayers.
2002 Apr 19
Myristyl and palmityl acylation of pI 5.1 carboxylesterase from porcine intestine and liver.
2002 Feb
Oxidative stress induced cytokine production in isolated rat pancreatic acinar cells: effects of small-molecule antioxidants.
2002 Feb
Enzymatic reaction of hydrogen peroxide-dependent peroxygenase cytochrome P450s: kinetic deuterium isotope effects and analyses by resonance Raman spectroscopy.
2002 Feb 12
Serum free fatty acid pattern and risk of myocardial infarction: a case-control study.
2002 Jan
[Fatty acid-induced reversal of general anesthesia: chain length-dependence of antagonizing potencies of fatty acids].
2002 Jan
Interaction of bovine (BSA) and human (HSA) serum albumins with ionic surfactants: spectroscopy and modelling.
2002 Jan 31
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Rous sarcoma virus-transformed cells were labeled for 2 h with either 1 mCi of [3H]palmitic acid or 0.2 mCi of [3H]myristic acid, and p60src was isolated by immunoprecipitation. The incorporation of [3H]myristic acid into p60src was ca. 100-fold greater than the incorporation of [3H]palmitic acid.
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:03:15 GMT 2023
Edited
by admin
on Fri Dec 15 19:03:15 GMT 2023
Record UNII
06BLC4V0IV
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM MYRISTATE
INCI  
INCI  
Official Name English
SODIUM MYRISTATE [INCI]
Common Name English
MYRISTIC ACID, SODIUM SALT
Common Name English
E-470(I)MYRISTIC ACID, SODIUM SALT
Common Name English
TETRADECANOIC ACID, SODIUM SALT
Common Name English
C 14-98/100MY, SODIUM SALT
Common Name English
INS NO.470(I)MYRISTIC ACID, SODIUM SALT
Common Name English
NIKKOL MK 140
Common Name English
INS-470(I)MYRISTIC ACID, SODIUM SALT
Common Name English
Classification Tree Code System Code
JECFA EVALUATION INS-470(I)
Created by admin on Fri Dec 15 19:03:15 GMT 2023 , Edited by admin on Fri Dec 15 19:03:15 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-470(I)
Created by admin on Fri Dec 15 19:03:15 GMT 2023 , Edited by admin on Fri Dec 15 19:03:15 GMT 2023
Code System Code Type Description
RXCUI
1744165
Created by admin on Fri Dec 15 19:03:15 GMT 2023 , Edited by admin on Fri Dec 15 19:03:15 GMT 2023
PRIMARY
WIKIPEDIA
Sodium myristate
Created by admin on Fri Dec 15 19:03:15 GMT 2023 , Edited by admin on Fri Dec 15 19:03:15 GMT 2023
PRIMARY
DAILYMED
06BLC4V0IV
Created by admin on Fri Dec 15 19:03:15 GMT 2023 , Edited by admin on Fri Dec 15 19:03:15 GMT 2023
PRIMARY
FDA UNII
06BLC4V0IV
Created by admin on Fri Dec 15 19:03:15 GMT 2023 , Edited by admin on Fri Dec 15 19:03:15 GMT 2023
PRIMARY
ECHA (EC/EINECS)
212-487-9
Created by admin on Fri Dec 15 19:03:15 GMT 2023 , Edited by admin on Fri Dec 15 19:03:15 GMT 2023
PRIMARY
EPA CompTox
DTXSID5042455
Created by admin on Fri Dec 15 19:03:15 GMT 2023 , Edited by admin on Fri Dec 15 19:03:15 GMT 2023
PRIMARY
PUBCHEM
23693095
Created by admin on Fri Dec 15 19:03:15 GMT 2023 , Edited by admin on Fri Dec 15 19:03:15 GMT 2023
PRIMARY
CAS
822-12-8
Created by admin on Fri Dec 15 19:03:15 GMT 2023 , Edited by admin on Fri Dec 15 19:03:15 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE