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Details

Stereochemistry ACHIRAL
Molecular Formula C14H27O2.Na
Molecular Weight 250.3533
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM MYRISTATE

SMILES

CCCCCCCCCCCCCC(=O)[O-].[Na+]

InChI

InChIKey=JUQGWKYSEXPRGL-UHFFFAOYSA-M
InChI=1S/C14H28O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16;/h2-13H2,1H3,(H,15,16);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C14H27O2
Molecular Weight 227.3635
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

CNS Activity

Curator's Comment:: Known to be CNS penetrant in rats. Human data not available.

Originator

Sources: DOI: 10.1080/14786444108650255

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Unknown

Approved Use

Unknown
Diagnostic
Unknown

Approved Use

Unknown
Inactive ingredient
Volu-Firm

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Comparative quantitative fatty acid analysis of triacylglycerols using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and gas chromatography.
2001
Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels.
2001
Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography.
2001 Apr 27
Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery.
2001 Aug
Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells.
2001 Aug
Biosynthesis and structural characterization of medium-chain-length poly(3-hydroxyalkanoates) produced by Pseudomonas aeruginosa from fatty acids.
2001 Aug 20
beta-Ketoacyl-[acyl carrier protein] synthase I of Escherichia coli: aspects of the condensation mechanism revealed by analyses of mutations in the active site pocket.
2001 Aug 21
Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis.
2001 Aug 7
Regulation of Golgi structure and function by ARF-like protein 1 (Arl1).
2001 Dec
Palmitate decreases proton pumping of liver-type cytochrome c oxidase.
2001 Dec
Characterization of the binding of Photobacterium phosphoreum P-flavin by Vibrio harveyi Luciferase.
2001 Dec 15
The kinetic and spectral characterization of the E. coli-expressed mammalian CYP4A7: cytochrome b5 effects vary with substrate.
2001 Jan 15
[Determination of higher fatty acids in human plasma].
2001 Jul
Fatty acid remodeling of glycosyl phosphatidylinositol anchors in Trypanosoma brucei: incorporation of fatty acids other than myristate.
2001 Jul
Ca2+-myristoyl switch and membrane binding of chemically acylated neurocalcins.
2001 Jul 10
N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons.
2001 Jun
Expression, purification and characterization of cytochrome P450 Biol: a novel P450 involved in biotin synthesis in Bacillus subtilis.
2001 Jun
Differential mechanisms of glucose and palmitate in augmentation of insulin secretion in mouse pancreatic islets.
2001 Jun
Regulation of G proteins by covalent modification.
2001 Mar 26
Acrylic resins as rate-controlling membranes in novel formulation of a nine-day 17beta-estradiol transdermal delivery system: in vitro and release modifier effect evaluation.
2001 May
Morbid myristoylation.
2001 May
Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase.
2001 May 18
Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.
2001 May 29
Fatty acid profiles of nitrite-oxidizing bacteria reflect their phylogenetic heterogeneity.
2001 Nov
Inhibition and regulation of rat liver L-threonine dehydrogenase by different fatty acids and their derivatives.
2001 Nov 7
Enzyme activity of the cytochrome P-450 monooxygenase system in the presence of single chain lipid molecules.
2001 Nov-Dec
Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells.
2001 Oct
Effects of incubator humidity and hen age on yolk composition in broiler hatching eggs from young breeders.
2001 Oct
Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation.
2001 Oct 1
Site-directed mutagenesis of the putative distal helix of peroxygenase cytochrome P450.
2001 Oct 1
Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members.
2001 Oct 19
Rational design of diflunisal analogues with reduced affinity for human serum albumin.
2001 Oct 31
Propranolol increases phosphatidic acid level via activation of phospholipase D.
2001 Sep
Rat pancreatic acinar cells express a cytosolic phospholipase D1b isoform that is not regulated by cholecystokinin.
2001 Sep
Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14).
2001 Sep 14
Optimization of carbohydrate fatty acid ester synthesis in organic media by a lipase from Candida antarctica.
2001 Sep 20
Coexpression of proteins with methionine aminopeptidase and/or N-myristoyltransferase in Escherichia coli to increase acylation and homogeneity of protein preparations.
2002
Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction.
2002 Apr 19
Myristoylated alanine-rich C kinase substrate (MARCKS) sequesters spin-labeled phosphatidylinositol 4,5-bisphosphate in lipid bilayers.
2002 Apr 19
Myristyl and palmityl acylation of pI 5.1 carboxylesterase from porcine intestine and liver.
2002 Feb
Differences in the fatty acid composition of larvae and metamorphosing sea lampreys, Petromyzon marinus.
2002 Feb
Oxidative stress induced cytokine production in isolated rat pancreatic acinar cells: effects of small-molecule antioxidants.
2002 Feb
Enzymatic reaction of hydrogen peroxide-dependent peroxygenase cytochrome P450s: kinetic deuterium isotope effects and analyses by resonance Raman spectroscopy.
2002 Feb 12
Serum free fatty acid pattern and risk of myocardial infarction: a case-control study.
2002 Jan
[Fatty acid-induced reversal of general anesthesia: chain length-dependence of antagonizing potencies of fatty acids].
2002 Jan
Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease.
2002 Jan
Differences in calmodulin and calmodulin-binding proteins in phasic and tonic smooth muscles.
2002 Jan
Permeation of a myristoylated dipeptide across the buccal mucosa: topological distribution and evaluation of tissue integrity.
2002 Jan 1
Interaction of bovine (BSA) and human (HSA) serum albumins with ionic surfactants: spectroscopy and modelling.
2002 Jan 31
The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase.
2002 Jan 4
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Rous sarcoma virus-transformed cells were labeled for 2 h with either 1 mCi of [3H]palmitic acid or 0.2 mCi of [3H]myristic acid, and p60src was isolated by immunoprecipitation. The incorporation of [3H]myristic acid into p60src was ca. 100-fold greater than the incorporation of [3H]palmitic acid.
Substance Class Chemical
Created
by admin
on Sat Jun 26 10:05:54 UTC 2021
Edited
by admin
on Sat Jun 26 10:05:54 UTC 2021
Record UNII
06BLC4V0IV
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM MYRISTATE
INCI  
INCI  
Official Name English
SODIUM MYRISTATE [INCI]
Common Name English
MYRISTIC ACID, SODIUM SALT
Common Name English
E-470(I)MYRISTIC ACID, SODIUM SALT
Common Name English
TETRADECANOIC ACID, SODIUM SALT
Common Name English
C 14-98/100MY, SODIUM SALT
Common Name English
INS NO.470(I)MYRISTIC ACID, SODIUM SALT
Common Name English
NIKKOL MK 140
Common Name English
INS-470(I)MYRISTIC ACID, SODIUM SALT
Common Name English
Classification Tree Code System Code
JECFA EVALUATION INS-470(I)
Created by admin on Sat Jun 26 10:05:54 UTC 2021 , Edited by admin on Sat Jun 26 10:05:54 UTC 2021
CODEX ALIMENTARIUS (GSFA) INS-470(I)
Created by admin on Sat Jun 26 10:05:54 UTC 2021 , Edited by admin on Sat Jun 26 10:05:54 UTC 2021
Code System Code Type Description
RXCUI
1744165
Created by admin on Sat Jun 26 10:05:54 UTC 2021 , Edited by admin on Sat Jun 26 10:05:54 UTC 2021
PRIMARY
WIKIPEDIA
Sodium myristate
Created by admin on Sat Jun 26 10:05:54 UTC 2021 , Edited by admin on Sat Jun 26 10:05:54 UTC 2021
PRIMARY
FDA UNII
06BLC4V0IV
Created by admin on Sat Jun 26 10:05:54 UTC 2021 , Edited by admin on Sat Jun 26 10:05:54 UTC 2021
PRIMARY
ECHA (EC/EINECS)
212-487-9
Created by admin on Sat Jun 26 10:05:54 UTC 2021 , Edited by admin on Sat Jun 26 10:05:54 UTC 2021
PRIMARY
EPA CompTox
822-12-8
Created by admin on Sat Jun 26 10:05:54 UTC 2021 , Edited by admin on Sat Jun 26 10:05:54 UTC 2021
PRIMARY
PUBCHEM
23693095
Created by admin on Sat Jun 26 10:05:54 UTC 2021 , Edited by admin on Sat Jun 26 10:05:54 UTC 2021
PRIMARY
CAS
822-12-8
Created by admin on Sat Jun 26 10:05:54 UTC 2021 , Edited by admin on Sat Jun 26 10:05:54 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE