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Details

Stereochemistry ACHIRAL
Molecular Formula C14H27O2.Na
Molecular Weight 250.3527
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM MYRISTATE

SMILES

[Na+].CCCCCCCCCCCCCC([O-])=O

InChI

InChIKey=JUQGWKYSEXPRGL-UHFFFAOYSA-M
InChI=1S/C14H28O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16;/h2-13H2,1H3,(H,15,16);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C14H27O2
Molecular Weight 227.363
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Ammonium myristate is passage-delaying substance. It was used as a substance for influencing gastrointestinal passage. The addition of ammonium myristate caused a delay of about 1.5 h in the transit time of the absorbing part of the gastrointestinal tract. The addition of ammonium myristate improves the availability of nitrofurantoin from a slow releasing dosage form - an average increase is 23.8% of the total amount of nitrofurantoin excreted in the urine compared to the values obtained from the reference dosage form without the additional substance. The kinetics of renal elimination of nitrofurantoin is characterized by the longer duration of urinary excretion.

CNS Activity

Curator's Comment: Known to be CNS penetrant in rats. Human data not available.

Originator

Sources: DOI: 10.1080/14786444108650255

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Unknown

Approved Use

Unknown
Diagnostic
Unknown

Approved Use

Unknown
Inactive ingredient
Volu-Firm

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Comparative quantitative fatty acid analysis of triacylglycerols using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and gas chromatography.
2001
Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels.
2001
Final report on the safety assessment of Cocoyl Sarcosine, Lauroyl Sarcosine, Myristoyl Sarcosine, Oleoyl Sarcosine, Stearoyl Sarcosine, Sodium Cocoyl Sarcosinate, Sodium Lauroyl Sarcosinate, Sodium Myristoyl Sarcosinate, Ammonium Cocoyl Sarcosinate, and Ammonium Lauroyl Sarcosinate.
2001
Effects of authentic and VLDL hydrolysis-derived fatty acids on vascular smooth muscle cell growth.
2001 Apr
Carotenoid esters in vegetables and fruits: a screening with emphasis on beta-cryptoxanthin esters.
2001 Apr
Thioacylation is required for targeting G-protein subunit G(o1alpha) to detergent-insoluble caveolin-containing membrane domains.
2001 Apr 15
Myristoylation of human immunodeficiency virus type 1 gag protein is required for efficient env protein transportation to the surface of cells.
2001 Apr 20
Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography.
2001 Apr 27
Flunitrazepam, a 7-nitro-1,4-benzodiazepine that is unable to bind to the indole-benzodiazepine site of human serum albumin.
2001 Apr 7
Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery.
2001 Aug
Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells.
2001 Aug
beta-Ketoacyl-[acyl carrier protein] synthase I of Escherichia coli: aspects of the condensation mechanism revealed by analyses of mutations in the active site pocket.
2001 Aug 21
Overexpression of the myristoylated alanine-rich C-kinase substrate inhibits cell adhesion to extracellular matrix components.
2001 Aug 24
Regulation of Golgi structure and function by ARF-like protein 1 (Arl1).
2001 Dec
Palmitate decreases proton pumping of liver-type cytochrome c oxidase.
2001 Dec
Isolation and structural characterization of an R-form lipopolysaccharide from Yersinia enterocolitica serotype O:8.
2001 Feb
Cellular and viral Fos proteins are degraded by different proteolytic systems.
2001 Feb 22
The kinetic and spectral characterization of the E. coli-expressed mammalian CYP4A7: cytochrome b5 effects vary with substrate.
2001 Jan 15
[Determination of higher fatty acids in human plasma].
2001 Jul
Fatty acid remodeling of glycosyl phosphatidylinositol anchors in Trypanosoma brucei: incorporation of fatty acids other than myristate.
2001 Jul
HIV-1 Nef promotes survival of myeloid cells by a Stat3-dependent pathway.
2001 Jul 6
Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands.
2001 Jul 6
N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons.
2001 Jun
Differential mechanisms of glucose and palmitate in augmentation of insulin secretion in mouse pancreatic islets.
2001 Jun
A Chlamydia trachomatis UDP-N-acetylglucosamine acyltransferase selective for myristoyl-acyl carrier protein. Expression in Escherichia coli and formation of hybrid lipid A species.
2001 Jun 1
Crystal structure analysis of warfarin binding to human serum albumin: anatomy of drug site I.
2001 Jun 22
Self-assembly of regular hollow icosahedra in salt-free catanionic solutions.
2001 Jun 7
Imidazoline I(1) receptor-induced activation of phosphatidylcholine-specific phospholipase C elicits mitogen-activated protein kinase phosphorylation in PC12 cells.
2001 Mar
Regulation of G proteins by covalent modification.
2001 Mar 26
Acrylic resins as rate-controlling membranes in novel formulation of a nine-day 17beta-estradiol transdermal delivery system: in vitro and release modifier effect evaluation.
2001 May
The effect of temperature on the fatty acids and isozymes of a psychrotrophic and two mesophilic species of Xenorhabdus, a bacterial symbiont of entomopathogenic nematodes.
2001 May
N-terminal myristylation of HBV preS1 domain enhances receptor recognition.
2001 May
Ca(2+)- and myristoylation-dependent association of calcineurin with phosphatidylserine.
2001 May
Morbid myristoylation.
2001 May
A fluorogenic reagent, 4-mercapto-7-methylthio-2,1,3-benzoxadiazole for carboxylic acids, designed by prediction of the fluorescence intensity.
2001 May 15
Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase.
2001 May 18
Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.
2001 May 29
Fatty acid profiles of nitrite-oxidizing bacteria reflect their phylogenetic heterogeneity.
2001 Nov
Effects of incubator humidity and hen age on yolk composition in broiler hatching eggs from young breeders.
2001 Oct
Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation.
2001 Oct 1
Site-directed mutagenesis of the putative distal helix of peroxygenase cytochrome P450.
2001 Oct 1
Propranolol increases phosphatidic acid level via activation of phospholipase D.
2001 Sep
Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14).
2001 Sep 14
Coexpression of proteins with methionine aminopeptidase and/or N-myristoyltransferase in Escherichia coli to increase acylation and homogeneity of protein preparations.
2002
Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction.
2002 Apr 19
Myristyl and palmityl acylation of pI 5.1 carboxylesterase from porcine intestine and liver.
2002 Feb
Differences in the fatty acid composition of larvae and metamorphosing sea lampreys, Petromyzon marinus.
2002 Feb
Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease.
2002 Jan
Differences in calmodulin and calmodulin-binding proteins in phasic and tonic smooth muscles.
2002 Jan
Permeation of a myristoylated dipeptide across the buccal mucosa: topological distribution and evaluation of tissue integrity.
2002 Jan 1
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Rous sarcoma virus-transformed cells were labeled for 2 h with either 1 mCi of [3H]palmitic acid or 0.2 mCi of [3H]myristic acid, and p60src was isolated by immunoprecipitation. The incorporation of [3H]myristic acid into p60src was ca. 100-fold greater than the incorporation of [3H]palmitic acid.
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:03:15 UTC 2023
Edited
by admin
on Fri Dec 15 19:03:15 UTC 2023
Record UNII
06BLC4V0IV
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM MYRISTATE
INCI  
INCI  
Official Name English
SODIUM MYRISTATE [INCI]
Common Name English
MYRISTIC ACID, SODIUM SALT
Common Name English
E-470(I)MYRISTIC ACID, SODIUM SALT
Common Name English
TETRADECANOIC ACID, SODIUM SALT
Common Name English
C 14-98/100MY, SODIUM SALT
Common Name English
INS NO.470(I)MYRISTIC ACID, SODIUM SALT
Common Name English
NIKKOL MK 140
Common Name English
INS-470(I)MYRISTIC ACID, SODIUM SALT
Common Name English
Classification Tree Code System Code
JECFA EVALUATION INS-470(I)
Created by admin on Fri Dec 15 19:03:15 UTC 2023 , Edited by admin on Fri Dec 15 19:03:15 UTC 2023
CODEX ALIMENTARIUS (GSFA) INS-470(I)
Created by admin on Fri Dec 15 19:03:15 UTC 2023 , Edited by admin on Fri Dec 15 19:03:15 UTC 2023
Code System Code Type Description
RXCUI
1744165
Created by admin on Fri Dec 15 19:03:15 UTC 2023 , Edited by admin on Fri Dec 15 19:03:15 UTC 2023
PRIMARY
WIKIPEDIA
Sodium myristate
Created by admin on Fri Dec 15 19:03:15 UTC 2023 , Edited by admin on Fri Dec 15 19:03:15 UTC 2023
PRIMARY
DAILYMED
06BLC4V0IV
Created by admin on Fri Dec 15 19:03:15 UTC 2023 , Edited by admin on Fri Dec 15 19:03:15 UTC 2023
PRIMARY
FDA UNII
06BLC4V0IV
Created by admin on Fri Dec 15 19:03:15 UTC 2023 , Edited by admin on Fri Dec 15 19:03:15 UTC 2023
PRIMARY
ECHA (EC/EINECS)
212-487-9
Created by admin on Fri Dec 15 19:03:15 UTC 2023 , Edited by admin on Fri Dec 15 19:03:15 UTC 2023
PRIMARY
EPA CompTox
DTXSID5042455
Created by admin on Fri Dec 15 19:03:15 UTC 2023 , Edited by admin on Fri Dec 15 19:03:15 UTC 2023
PRIMARY
PUBCHEM
23693095
Created by admin on Fri Dec 15 19:03:15 UTC 2023 , Edited by admin on Fri Dec 15 19:03:15 UTC 2023
PRIMARY
CAS
822-12-8
Created by admin on Fri Dec 15 19:03:15 UTC 2023 , Edited by admin on Fri Dec 15 19:03:15 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE