Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H27O2.Na |
Molecular Weight | 250.3527 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CCCCCCCCCCCCCC([O-])=O
InChI
InChIKey=JUQGWKYSEXPRGL-UHFFFAOYSA-M
InChI=1S/C14H28O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16;/h2-13H2,1H3,(H,15,16);/q;+1/p-1
Molecular Formula | C14H27O2 |
Molecular Weight | 227.363 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Na |
Molecular Weight | 22.98976928 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/9323584 | https://elibrary.ru/item.asp?id=5420911 | http://www.tuscany-diet.net/lipids/list-of-fatty-acids/myristic/ | https://www.ncbi.nlm.nih.gov/pubmed/19154695 | https://www.ncbi.nlm.nih.gov/pubmed/20634506DOI: 10.1016/0378-5173(89)90003-3https://www.ewg.org/skindeep/ingredient/706137/SODIUM_MYRISTATE/ | Burdock, G.A. (1997) Encyclopedia of Food and Color Additives, page 2575, retrieved from: https://books.google.ru/books?id=NtaR9i3hYCYC | Igoe, R.S. (2013) Dictionary of Food Ingredients, page 129, retrieved from: https://books.google.ru/books?id=WEKEBwAAQBAJ
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9323584 | https://elibrary.ru/item.asp?id=5420911 | http://www.tuscany-diet.net/lipids/list-of-fatty-acids/myristic/ | https://www.ncbi.nlm.nih.gov/pubmed/19154695 | https://www.ncbi.nlm.nih.gov/pubmed/20634506DOI: 10.1016/0378-5173(89)90003-3https://www.ewg.org/skindeep/ingredient/706137/SODIUM_MYRISTATE/ | Burdock, G.A. (1997) Encyclopedia of Food and Color Additives, page 2575, retrieved from: https://books.google.ru/books?id=NtaR9i3hYCYC | Igoe, R.S. (2013) Dictionary of Food Ingredients, page 129, retrieved from: https://books.google.ru/books?id=WEKEBwAAQBAJ
Sodium myristate is the sodium salt of myristic acid. It is used in the food as the binder, emulsifier and anticaking agent. It is one of the commonly occurring soaps. It is used in cosmetic as a cleansing and emulsifying agent.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3335863
Curator's Comment: Known to be CNS penetrant in rats. Human data not available.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL5088 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20920594 |
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Target ID: CHEMBL2021749 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20920594 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Diagnostic | Unknown Approved UseUnknown |
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Sources: https://www.ncbi.nlm.nih.gov/pubmed/26800189 |
Diagnostic | Unknown Approved UseUnknown |
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Inactive ingredient | Volu-Firm Approved UseUnknown |
PubMed
Title | Date | PubMed |
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The mitigating effects of phosphatidylcholines on bile salt- and lysophosphatidylcholine-induced membrane damage. | 1992 Aug |
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Thermodynamics of binding water and solute to powdered long-chain salts of fatty acids. | 1994 Oct |
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Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. | 1999 Jul 14 |
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Evaluation of skin damage caused by percutaneous absorption enhancers using fractal analysis. | 2000 Apr |
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Study on the lifetime and attenuation properties of microbubbles coated with carboxylic acid salts. | 2000 Nov |
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Effect of Protonation on the Solution and Phase Behavior of Aqueous Sodium Myristate. | 2000 Nov 1 |
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Longitudinal study of fatty acids in plasma and erythrocyte phospholipids during pregnancy. | 2001 |
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Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels. | 2001 |
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Final report on the safety assessment of Cocoyl Sarcosine, Lauroyl Sarcosine, Myristoyl Sarcosine, Oleoyl Sarcosine, Stearoyl Sarcosine, Sodium Cocoyl Sarcosinate, Sodium Lauroyl Sarcosinate, Sodium Myristoyl Sarcosinate, Ammonium Cocoyl Sarcosinate, and Ammonium Lauroyl Sarcosinate. | 2001 |
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Effects of authentic and VLDL hydrolysis-derived fatty acids on vascular smooth muscle cell growth. | 2001 Apr |
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Carotenoid esters in vegetables and fruits: a screening with emphasis on beta-cryptoxanthin esters. | 2001 Apr |
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Thioacylation is required for targeting G-protein subunit G(o1alpha) to detergent-insoluble caveolin-containing membrane domains. | 2001 Apr 15 |
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Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery. | 2001 Aug |
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Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells. | 2001 Aug |
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Biosynthesis and structural characterization of medium-chain-length poly(3-hydroxyalkanoates) produced by Pseudomonas aeruginosa from fatty acids. | 2001 Aug 20 |
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Overexpression of the myristoylated alanine-rich C-kinase substrate inhibits cell adhesion to extracellular matrix components. | 2001 Aug 24 |
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Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis. | 2001 Aug 7 |
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Characterization of the binding of Photobacterium phosphoreum P-flavin by Vibrio harveyi Luciferase. | 2001 Dec 15 |
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Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling. | 2001 Feb 23 |
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The neuronal calcium sensor family of Ca2+-binding proteins. | 2001 Jan 1 |
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Characterization of a new member of the fatty acid-binding protein family that binds all-trans-retinol. | 2001 Jan 12 |
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The kinetic and spectral characterization of the E. coli-expressed mammalian CYP4A7: cytochrome b5 effects vary with substrate. | 2001 Jan 15 |
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Drosophila embryos lacking N-myristoyltransferase have multiple developmental defects. | 2001 Jan 15 |
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Influence of myristoylation, phosphorylation, and deamidation on the structural behavior of the N-terminus of the catalytic subunit of cAMP-dependent protein kinase. | 2001 Jan 9 |
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[Determination of higher fatty acids in human plasma]. | 2001 Jul |
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Molecular characterization of StCDPK1, a calcium-dependent protein kinase from Solanum tuberosum that is induced at the onset of tuber development. | 2001 Jul |
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Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands. | 2001 Jul 6 |
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N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons. | 2001 Jun |
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Cox-2 inhibitory effects of naturally occurring and modified fatty acids. | 2001 Jun |
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Imidazoline I(1) receptor-induced activation of phosphatidylcholine-specific phospholipase C elicits mitogen-activated protein kinase phosphorylation in PC12 cells. | 2001 Mar |
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Regulation of G proteins by covalent modification. | 2001 Mar 26 |
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N-terminal myristylation of HBV preS1 domain enhances receptor recognition. | 2001 May |
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Ca(2+)- and myristoylation-dependent association of calcineurin with phosphatidylserine. | 2001 May |
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Morbid myristoylation. | 2001 May |
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A fluorogenic reagent, 4-mercapto-7-methylthio-2,1,3-benzoxadiazole for carboxylic acids, designed by prediction of the fluorescence intensity. | 2001 May 15 |
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Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis. | 2001 May 29 |
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Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells. | 2001 Oct |
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Effects of incubator humidity and hen age on yolk composition in broiler hatching eggs from young breeders. | 2001 Oct |
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Ethanol- and nicotine-induced membrane changes in embryonic and neonatal chick brains. | 2001 Oct |
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Site-directed mutagenesis of the putative distal helix of peroxygenase cytochrome P450. | 2001 Oct 1 |
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The biology and enzymology of protein N-myristoylation. | 2001 Oct 26 |
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Rational design of diflunisal analogues with reduced affinity for human serum albumin. | 2001 Oct 31 |
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Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14). | 2001 Sep 14 |
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Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids. | 2001 Sep 28 |
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[Fatty acid-induced reversal of general anesthesia: chain length-dependence of antagonizing potencies of fatty acids]. | 2002 Jan |
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Adsorption and direct probing of fibrinogen and sodium myristate at the air/water interface. | 2002 Jun 15 |
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Single-step purification of myristoylated and nonmyristoylated recoverin and substrate dependence of myristoylation level. | 2006 Feb 1 |
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Self assembly of anastomosis-like superstructures in fatty acid/guanidine hydrochloride aqueous dispersions. | 2010 Jan 15 |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2981363
Rous sarcoma virus-transformed cells were labeled for 2 h with either 1 mCi of [3H]palmitic acid or 0.2 mCi of [3H]myristic acid, and p60src was isolated by immunoprecipitation. The incorporation of [3H]myristic acid into p60src was ca. 100-fold greater than the incorporation of [3H]palmitic acid.
Substance Class |
Chemical
Created
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admin
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Edited
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Record UNII |
06BLC4V0IV
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Record Status |
Validated (UNII)
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Record Version |
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JECFA EVALUATION |
INS-470(I)
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CODEX ALIMENTARIUS (GSFA) |
INS-470(I)
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Sodium myristate
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |