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Details

Stereochemistry ACHIRAL
Molecular Formula H2O
Molecular Weight 18.0153
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of WATER

SMILES

O

InChI

InChIKey=XLYOFNOQVPJJNP-UHFFFAOYSA-N
InChI=1S/H2O/h1H2

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018

Sodium is the primary cation (positive ion) in extracellular fluids in animals and humans. Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste. " Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
POTASSIUM HYDROXIDE

Approved Use

Used as a softener for nail grooves. Also used as a slide medium in Potassium Hydroxide preparations. Apply to nail in office.

Launch Date

2010
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Kayexalate

Approved Use

INDICATION AND USAGE Kayexalate is indicated for the treatment of hyperkalemia.

Launch Date

1958
PubMed

PubMed

TitleDatePubMed
Hemolysis in dialyzed patients: tap water-induced red blood cell metabolic deficiency.
1972
Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.
1994 Sep 30
Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea.
1997 Aug 15
Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol.
1998 Mar 6
Molecular characterization of a broad selectivity neutral solute channel.
1998 Sep 18
Effect of beta-blockers on free radical-induced cardiac contractile dysfunction.
1999 Jul 27
Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes.
1999 Sep-Oct
Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3.
2001 Jan 5
Reduced nephrotoxicity of conventional amphotericin B therapy after minimal nephroprotective measures: animal experiments and clinical study.
2002 Aug 1
NKCC activity restores muscle water during hyperosmotic challenge independent of insulin, ERK, and p38 MAPK.
2003 Mar
Reversible silencing of CFTR chloride channels by glutathionylation.
2005 Feb
Effect of dioxane on the structure and hydration-dehydration of alpha-chymotrypsin as measured by FTIR spectroscopy.
2005 Jun 15
The mineralocorticoid receptor: a journey exploring its diversity and specificity of action.
2005 Sep
Inherited sodium avid states.
2006 Apr
Cloning and characterization of porcine aquaporin 1 water channel expressed extensively in gastrointestinal system.
2006 Feb 21
The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure.
2006 Jan
Mechanisms of disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity.
2006 Nov
The story of the discovery of aquaporins: convergent evolution of ideas--but who got there first?
2006 Oct 30
Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions.
2007 Dec
Gill membrane remodeling with soft-water acclimation in zebrafish (Danio rerio).
2007 Jun 19
A stable and sensitive testing system for potential carcinogens based on DNA damage-induced gene expression in human HepG2 cell.
2009 Feb
Tobramycin-induced aquagenic wrinkling of the palms in a patient with cystic fibrosis.
2009 Jul
Evidence for the involvement of aquaporins in sperm motility activation of the teleost gilthead sea bream (Sparus aurata).
2009 Nov
Molecular mechanisms of how mercury inhibits water permeation through aquaporin-1: understanding by molecular dynamics simulation.
2010 Apr 21
Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia.
2010 Sep 6
Enhanced expression of heme oxygenase-1 and carbon monoxide excitatory effects in oxytocin and vasopressin neurones during water deprivation.
2012 Apr
Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux.
2013 Feb
Patents

Sample Use Guides

10% Potassium Hydroxide
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:48:33 GMT 2023
Edited
by admin
on Fri Dec 15 15:48:33 GMT 2023
Record UNII
059QF0KO0R
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
WATER
INCI   MI   VANDF   WHO-DD  
INCI  
Official Name English
Water [WHO-DD]
Common Name English
NSC-147337
Code English
STERILE WATER
Common Name English
ULTREX II ULTRAPURE
Common Name English
HYDROGEN OXIDE (H2O)
Systematic Name English
WATER [INCI]
Common Name English
WATER [JAN]
Common Name English
AQUA
INCI  
INCI  
Official Name English
WATER [VANDF]
Common Name English
WATER [MI]
Common Name English
AQUAFINA
Common Name English
WATER/EAU/AQUA
Common Name English
PURIFIED WATER [MART.]
Common Name English
B1217 [LANGUAL]
Code English
R-718
Code English
AQUA [INCI]
Common Name English
Classification Tree Code System Code
DSLD 1013 (Number of products:234)
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 1089
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 1081
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 1236
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 1096
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
LOINC 59016-6
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 1082
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
Code System Code Type Description
PUBCHEM
962
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
CAS
7732-18-5
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
MESH
D014867
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
ECHA (EC/EINECS)
231-791-2
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
EVMPD
SUB15717MIG
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
SMS_ID
100000085825
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
FDA UNII
059QF0KO0R
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
DAILYMED
059QF0KO0R
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
NCI_THESAURUS
C65147
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
ChEMBL
CHEMBL1098659
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
MERCK INDEX
m11507
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY Merck Index
NSC
147337
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
CHEBI
15377
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
RXCUI
11295
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
DRUG BANK
DB09145
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
EVMPD
SUB29180
Created by admin on Fri Dec 15 15:48:33 GMT 2023 , Edited by admin on Fri Dec 15 15:48:33 GMT 2023
PRIMARY
Related Record Type Details
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
PARENT -> IMPURITY
Water (2.5.12): maximum 0.5 per cent, determined on 0.500 g.
EP
PARENT -> IMPURITY
Water: maximum 1.0 per cent, determined on 0.250 g.
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
ACTIVE MOIETY