Details
Stereochemistry | ACHIRAL |
Molecular Formula | H2O |
Molecular Weight | 18.0153 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O
InChI
InChIKey=XLYOFNOQVPJJNP-UHFFFAOYSA-N
InChI=1S/H2O/h1H2
Molecular Formula | H2O |
Molecular Weight | 18.0153 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/27904181 | https://www.ncbi.nlm.nih.gov/pubmed/27382594http://www.hmdb.ca/metabolites/HMDB00588Curator's Comment: description was created based on several sources, including
https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27904181 | https://www.ncbi.nlm.nih.gov/pubmed/27382594http://www.hmdb.ca/metabolites/HMDB00588
Curator's Comment: description was created based on several sources, including
https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018
Sodium is the primary cation (positive ion) in extracellular fluids in animals and humans. Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste. " Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2331043 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28416444 |
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Target ID: CHEMBL2095186 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23284664 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | POTASSIUM HYDROXIDE Approved UseUsed as a softener for nail grooves. Also used as a slide medium in Potassium Hydroxide preparations. Apply to nail in office. Launch Date2010 |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Primary | Kayexalate Approved UseINDICATION AND USAGE
Kayexalate is indicated for the treatment of hyperkalemia. Launch Date1958 |
PubMed
Title | Date | PubMed |
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Hemolysis in dialyzed patients: tap water-induced red blood cell metabolic deficiency. | 1972 |
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Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation. | 1994 Sep 30 |
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Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. | 1997 Aug 15 |
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Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. | 1998 Mar 6 |
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Molecular characterization of a broad selectivity neutral solute channel. | 1998 Sep 18 |
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Effect of beta-blockers on free radical-induced cardiac contractile dysfunction. | 1999 Jul 27 |
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Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes. | 1999 Sep-Oct |
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Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. | 2001 Jan 5 |
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Reduced nephrotoxicity of conventional amphotericin B therapy after minimal nephroprotective measures: animal experiments and clinical study. | 2002 Aug 1 |
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NKCC activity restores muscle water during hyperosmotic challenge independent of insulin, ERK, and p38 MAPK. | 2003 Mar |
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Reversible silencing of CFTR chloride channels by glutathionylation. | 2005 Feb |
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Effect of dioxane on the structure and hydration-dehydration of alpha-chymotrypsin as measured by FTIR spectroscopy. | 2005 Jun 15 |
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The mineralocorticoid receptor: a journey exploring its diversity and specificity of action. | 2005 Sep |
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Inherited sodium avid states. | 2006 Apr |
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Cloning and characterization of porcine aquaporin 1 water channel expressed extensively in gastrointestinal system. | 2006 Feb 21 |
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The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure. | 2006 Jan |
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Mechanisms of disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity. | 2006 Nov |
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The story of the discovery of aquaporins: convergent evolution of ideas--but who got there first? | 2006 Oct 30 |
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Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions. | 2007 Dec |
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Gill membrane remodeling with soft-water acclimation in zebrafish (Danio rerio). | 2007 Jun 19 |
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A stable and sensitive testing system for potential carcinogens based on DNA damage-induced gene expression in human HepG2 cell. | 2009 Feb |
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Tobramycin-induced aquagenic wrinkling of the palms in a patient with cystic fibrosis. | 2009 Jul |
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Evidence for the involvement of aquaporins in sperm motility activation of the teleost gilthead sea bream (Sparus aurata). | 2009 Nov |
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Molecular mechanisms of how mercury inhibits water permeation through aquaporin-1: understanding by molecular dynamics simulation. | 2010 Apr 21 |
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Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia. | 2010 Sep 6 |
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Enhanced expression of heme oxygenase-1 and carbon monoxide excitatory effects in oxytocin and vasopressin neurones during water deprivation. | 2012 Apr |
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Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux. | 2013 Feb |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27904181
10% Potassium Hydroxide
Route of Administration:
Topical
Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 15:48:33 GMT 2023
by
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on
Fri Dec 15 15:48:33 GMT 2023
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Record UNII |
059QF0KO0R
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Record Status |
Validated (UNII)
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DSLD |
1013 (Number of products:234)
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Food Contact Sustance Notif, (FCN No.) |
FCN NO. 1089
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Food Contact Sustance Notif, (FCN No.) |
FCN NO. 1081
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Food Contact Sustance Notif, (FCN No.) |
FCN NO. 1236
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Food Contact Sustance Notif, (FCN No.) |
FCN NO. 1096
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LOINC |
59016-6
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Food Contact Sustance Notif, (FCN No.) |
FCN NO. 1082
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962
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7732-18-5
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D014867
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231-791-2
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SUB15717MIG
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100000085825
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059QF0KO0R
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059QF0KO0R
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C65147
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CHEMBL1098659
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m11507
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147337
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15377
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11295
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DB09145
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SUB29180
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PARENT -> IMPURITY |
Water (2.5.12): maximum 0.5 per cent, determined on 0.500 g.
EP
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PARENT -> IMPURITY |
Water: maximum 1.0 per cent, determined on 0.250 g.
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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ACTIVE MOIETY |
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