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Details

Stereochemistry RACEMIC
Molecular Formula C10H15NO
Molecular Weight 165.2326
Optical Activity ( + / - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RACEPHEDRINE

SMILES

C[C@]([H])([C@]([H])(c1ccccc1)O)NC

InChI

InChIKey=KWGRBVOPPLSCSI-PSASIEDQSA-N
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula C10H15NO
Molecular Weight 165.2326
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Racephedrine in combination with theophylline, phenobarbital was used to treat bronchial asthma. However, its application was substituted more effective agent. In addition, FDA has reviewed the final monograph for over-the-counter bronchodilator drug products to add additional warnings and to revise the indications in the labeling of products containing racephedrine hydrochloride.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Unknown

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
79.4 ng/mL
22 mg single, oral
dose: 22 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
EPHEDRINE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
751 ng × h/mL
22 mg single, oral
dose: 22 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
EPHEDRINE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
6.75 h
22 mg single, oral
dose: 22 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
EPHEDRINE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
PubMed

PubMed

TitleDatePubMed
RACEPHEDRINE hydrochloride capsules.
1949 Jul-Aug
A racephedrine-phenyltoloxamine-containing compound (Ephoxamine) in the treatment of bronchial asthma.
1961 Jul
[Delayed-action effect of a racephedrine, theophylline and phenobarbital combination on asthma. Study on 100 cases].
1968 Jul-Aug
[The in-vitro histamine liberation in human leukocytes sensitized by grass pollen. Pharmacological application of the study on racephedrine and theophylline (proceedings)].
1977 Jun
Labeling for bronchodilators to treat asthma; cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use. Final rule.
2011 Jul 26
Patents

Patents

Sample Use Guides

Unknown
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 09:17:56 UTC 2021
Edited
by admin
on Sat Jun 26 09:17:56 UTC 2021
Record UNII
03VRY66076
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RACEPHEDRINE
INN   WHO-DD  
INN  
Official Name English
EPHEDRINE DL-FORM
MI  
Common Name English
RACEPHEDRINE [INN]
Common Name English
BENZENEMETHANOL, .ALPHA.-((1R)-1-(METHYLAMINO)ETHYL)-, (.ALPHA.S)-REL-
Common Name English
EPHEDRINE DL-FORM [MI]
Common Name English
(1R,2S)-(-)-EPHEDRINE
Common Name English
BENZENEMETHANOL, .ALPHA.-(1-(METHYLAMINO)ETHYL)-, (R*,S*)-(+/-)-
Systematic Name English
RACEPHEDRINE [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29709
Created by admin on Sat Jun 26 09:17:56 UTC 2021 , Edited by admin on Sat Jun 26 09:17:56 UTC 2021
CFR 21 CFR 119.1
Created by admin on Sat Jun 26 09:17:56 UTC 2021 , Edited by admin on Sat Jun 26 09:17:56 UTC 2021
Code System Code Type Description
EVMPD
SUB10237MIG
Created by admin on Sat Jun 26 09:17:56 UTC 2021 , Edited by admin on Sat Jun 26 09:17:56 UTC 2021
PRIMARY
DRUG BANK
DB14752
Created by admin on Sat Jun 26 09:17:56 UTC 2021 , Edited by admin on Sat Jun 26 09:17:56 UTC 2021
PRIMARY
ECHA (EC/EINECS)
202-017-0
Created by admin on Sat Jun 26 09:17:56 UTC 2021 , Edited by admin on Sat Jun 26 09:17:56 UTC 2021
PRIMARY
MERCK INDEX
M4933
Created by admin on Sat Jun 26 09:17:56 UTC 2021 , Edited by admin on Sat Jun 26 09:17:56 UTC 2021
PRIMARY Merck Index
FDA UNII
03VRY66076
Created by admin on Sat Jun 26 09:17:56 UTC 2021 , Edited by admin on Sat Jun 26 09:17:56 UTC 2021
PRIMARY
NCI_THESAURUS
C81363
Created by admin on Sat Jun 26 09:17:56 UTC 2021 , Edited by admin on Sat Jun 26 09:17:56 UTC 2021
PRIMARY
CAS
90-81-3
Created by admin on Sat Jun 26 09:17:56 UTC 2021 , Edited by admin on Sat Jun 26 09:17:56 UTC 2021
PRIMARY
INN
6626
Created by admin on Sat Jun 26 09:17:56 UTC 2021 , Edited by admin on Sat Jun 26 09:17:56 UTC 2021
PRIMARY
ChEMBL
CHEMBL2110656
Created by admin on Sat Jun 26 09:17:56 UTC 2021 , Edited by admin on Sat Jun 26 09:17:56 UTC 2021
PRIMARY
Related Record Type Details
DIASTEREOISOMER -> DIASTEREOISOMER
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY