U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C24H33Cl2NO5
Molecular Weight 486.429
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VILANTEROL

SMILES

OCC1=C(O)C=CC(=C1)[C@@H](O)CNCCCCCCOCCOCC2=C(Cl)C=CC=C2Cl

InChI

InChIKey=DAFYYTQWSAWIGS-DEOSSOPVSA-N
InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1

HIDE SMILES / InChI
Molecular Formula C24H33Cl2NO5
Molecular Weight 486.429
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including http://www.drugbank.ca/drugs/DB09082

Vilanterol (INN, USAN) is an ultra-long-acting β2 adrenoreceptor agonist (ultra-LABA), which was approved in May 2013 in combination with fluticasone furoate for sale as Breo Ellipta by GlaxoSmithKline for the treatment of chronic obstructive pulmonary disease (COPD). Its pharmacological effect is attributable to stimulation of intracellular adenylyl cyclase which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3’,5’-adenosine monophosphate (cAMP). Increases in cyclic AMP are associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. Vilanterol is available in following combinations: a) with inhaled corticosteroid fluticasone furoate — fluticasone furoate/vilanterol (trade names Breo Ellipta , Relvar Ellipta; b) with muscarinic antagonist umeclidinium bromide — umeclidinium bromide/vilanterol (trade name Anoro Ellipta).

Originator

Approval Year

2013
596
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2678
 9.42 null [pKi]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Secondary
Approved
8429
ANORO ELLIPTA

Approved Use

ANORO ELLIPTA is a combination of umeclidinium, an anticholinergic, and vilanterol, a long-acting beta2-adrenergic agonist (LABA), indicated for the long-term, once-daily, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD). Not indicated for relief of acute bronchospasm or for the treatment of asthma.

Launch Date

2013
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
205 pg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/25816315/
25 μg 1 times / day multiple, oral
dose: 25 μg
route of administration: Oral
experiment type: MULTIPLE
co-administered: UMECLIDINIUM
UMECLIDINIUM
 [NO STEREO] VILANTEROL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
239 pg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/25816315/
25 μg 1 times / day multiple, oral
dose: 25 μg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
[NO STEREO] VILANTEROL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
495.9 pg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23284643/
50 μg single, oral
dose: 50 μg
route of administration: Oral
experiment type: SINGLE
co-administered:
[NO STEREO] VILANTEROL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
118 pg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/25816315/
25 μg 1 times / day multiple, oral
dose: 25 μg
route of administration: Oral
experiment type: MULTIPLE
co-administered: UMECLIDINIUM
UMECLIDINIUM
 [NO STEREO] VILANTEROL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
214 pg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/25816315/
25 μg 1 times / day multiple, oral
dose: 25 μg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
[NO STEREO] VILANTEROL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
251.4 pg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23284643/
50 μg single, oral
dose: 50 μg
route of administration: Oral
experiment type: SINGLE
co-administered:
[NO STEREO] VILANTEROL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
1.84 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/25816315/
25 μg 1 times / day multiple, oral
dose: 25 μg
route of administration: Oral
experiment type: MULTIPLE
co-administered: UMECLIDINIUM
UMECLIDINIUM
 [NO STEREO] VILANTEROL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
0.42 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23284643/
50 μg single, oral
dose: 50 μg
route of administration: Oral
experiment type: SINGLE
co-administered:
[NO STEREO] VILANTEROL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
100 ug 1 times / day multiple, respiratory
Highest studied dose
Dose: 100 ug, 1 times / day
Route: respiratory
Route: multiple
Dose: 100 ug, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
healthy, 29.1 years (range: 21-53 years)
n = 9
Health Status: healthy
Age Group: 29.1 years (range: 21-53 years)
Sex: M
Population Size: 9
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
Other AEs: Nasopharyngitis, Constipation...
Other AEs:
Nasopharyngitis (1 patient)
Constipation (1 patient)
Hot flush (1 patient)
Muscle twitching (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
500 ug multiple, oral
Highest studied dose
Dose: 500 ug
Route: oral
Route: multiple
Dose: 500 ug
Sources:
https://pubmed.ncbi.nlm.nih.gov/23043183
healthy, 33.1 years (range: 19–47 years)
n = 9
Health Status: healthy
Age Group: 33.1 years (range: 19–47 years)
Sex: M
Population Size: 9
Sources:
https://pubmed.ncbi.nlm.nih.gov/23043183
Sources:
https://pubmed.ncbi.nlm.nih.gov/23043183
100 ug multiple, respiratory
Highest studied dose
Dose: 100 ug
Route: respiratory
Route: multiple
Dose: 100 ug
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
unhealthy, 36.9 years (range: 21-60 years)
n = 22
Health Status: unhealthy
Condition: asthma
Age Group: 36.9 years (range: 21-60 years)
Sex: M
Population Size: 22
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
Other AEs: Application site rash...
Other AEs:
Application site rash (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
AEs

AEs

AESignificanceDosePopulation
Constipation 1 patient
100 ug 1 times / day multiple, respiratory
Highest studied dose
Dose: 100 ug, 1 times / day
Route: respiratory
Route: multiple
Dose: 100 ug, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
healthy, 29.1 years (range: 21-53 years)
n = 9
Health Status: healthy
Age Group: 29.1 years (range: 21-53 years)
Sex: M
Population Size: 9
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
Hot flush 1 patient
100 ug 1 times / day multiple, respiratory
Highest studied dose
Dose: 100 ug, 1 times / day
Route: respiratory
Route: multiple
Dose: 100 ug, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
healthy, 29.1 years (range: 21-53 years)
n = 9
Health Status: healthy
Age Group: 29.1 years (range: 21-53 years)
Sex: M
Population Size: 9
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
Muscle twitching 1 patient
100 ug 1 times / day multiple, respiratory
Highest studied dose
Dose: 100 ug, 1 times / day
Route: respiratory
Route: multiple
Dose: 100 ug, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
healthy, 29.1 years (range: 21-53 years)
n = 9
Health Status: healthy
Age Group: 29.1 years (range: 21-53 years)
Sex: M
Population Size: 9
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
Nasopharyngitis 1 patient
100 ug 1 times / day multiple, respiratory
Highest studied dose
Dose: 100 ug, 1 times / day
Route: respiratory
Route: multiple
Dose: 100 ug, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
healthy, 29.1 years (range: 21-53 years)
n = 9
Health Status: healthy
Age Group: 29.1 years (range: 21-53 years)
Sex: M
Population Size: 9
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
Application site rash 1 patient
100 ug multiple, respiratory
Highest studied dose
Dose: 100 ug
Route: respiratory
Route: multiple
Dose: 100 ug
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
unhealthy, 36.9 years (range: 21-60 years)
n = 22
Health Status: unhealthy
Condition: asthma
Age Group: 36.9 years (range: 21-60 years)
Sex: M
Population Size: 22
Sources:
https://pubmed.ncbi.nlm.nih.gov/23232038
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
substrate
1737

inhibitor
1587
substrate
1037

inhibitor
1767
inhibitor
1852

substrate
1217

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP1A2
1524

CYP2C19
1478

P-gp
1461
P-gp
1537

CYP2C8
693

CYP2C19
991

CYP1A2
1054
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
P-gp
1650
 no [Inhibition 100 uM]
CYP1A2
1692
 no
CYP2C19
1553
 no
CYP2C9
1819
 no
CYP3A4
1925
 yes [IC50 4 uM]
CYP2D6
1891
 yes
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
CYP1A2
1054
 minor
CYP2C19
991
 minor
CYP2C8
693
 minor
CYP2C9
1037
 minor
CYP2D6
1217
 minor
P-gp
1537
 yes
unlikely
Comment: VI pharmacokinetics was not affected by P-gp inhibition. Drug interaction trials with a specific P-gp inhibitor and fluticasone furoate have not been conducted.
Page: 9.0
CYP3A4
1737
 yes
yes (co-administration study)
Comment: Co-administration with strong CYP3A4 and potent P-gp inhibitor ketoconazole, resulted in modest increases in mean FF AUC(0-24) and Cmax (by 36% and 33%, respectively) and mean VI AUC(0-t) and Cmax (by 65% and 22%, respectively)
Page: 9.0
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:75037
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:75037
ChemicalBook
CB22542797
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB22542797
MolPort
MolPort-044-560-195
https://www.molport.com/shop/molecule-link/MolPort-044-560-195
ZINC
ZINC000003991624
http://zinc15.docking.org/substances/ZINC000003991624
PubMed

PubMed

TitleDatePubMed
Patents

Patents

07361787
3
07439393
7
07776895
3
07982067
3
08198483
3
20040122014
6
20040167167
4
JP2013536800A
2

Sample Use Guides

In Vivo Use Guide
ANORO ELLIPTA (umeclidinium/vilanterol 62.5 mcg/25 mcg) should be administered as 1 inhalation once daily by the orally inhaled route only. ANORO ELLIPTA should be used at the same time every day. Do not use ANORO ELLIPTA more than 1 time every 24 hours.
Route of Administration: Respiratory
In Vitro Use Guide
Vilanterol (taken at 1nM) caused concentration related bronchodilation of human small airways when precontracted with histamine or carbachol and exhibited a comparable EC50 and efficacy (maximum percentage bronchodilation) within each spasmogen tested. EC50 value was 0.6 nM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:40:33 GMT 2023
Edited
by admin
on Fri Dec 15 17:40:33 GMT 2023
Record UNII
028LZY775B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VILANTEROL
INN   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
VILANTEROL [USAN]
Common Name English
1,3-BENZENEDIMETHANOL, .ALPHA.1-(((6-(2-((2,6-DICHLOROPHENYL)METHOXY)ETHOXY)HEXYL)AMINO)METHYL)-4-HYDROXY-, (.ALPHA.1R)-
Common Name English
VILANTEROL [VANDF]
Common Name English
GW642444
Code English
vilanterol [INN]
Common Name English
GW-642444
Code English
Vilanterol [WHO-DD]
Common Name English
GW642444X
Code English
GW-642444X
Code English
4-{(1R)-2-[(6-{2-[(2,6-Dichlorophenyl)methoxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol
Systematic Name English
Classification Tree Code System Code
EMA ASSESSMENT REPORTS LAVENTAIR (AUTHORIZED: PULMONARY DISEASE, CHRONIC OBSTRUCTIVE)
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
WHO-ATC R03AL08
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
NDF-RT N0000175779
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
WHO-VATC QR03AL03
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
NCI_THESAURUS C48149
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
WHO-ATC R03AL03
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
EMA ASSESSMENT REPORTS RELVAR ELLIPTA (AUTHORIZED: PULMONARY DISEASE, CHRONIC OBSTRUCTIVE)
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
NCI_THESAURUS C319
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
WHO-ATC R03AK10
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
WHO-VATC QR03AK10
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
Code System Code Type Description
IUPHAR
7353
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
RXCUI
1424884
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY RxNorm
SMS_ID
100000138094
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
LACTMED
Vilanterol
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
CAS
503068-34-6
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
USAN
UU-68
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
DAILYMED
028LZY775B
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
EPA CompTox
DTXSID80198318
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
DRUG BANK
DB09082
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
ChEMBL
CHEMBL1198857
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
INN
9198
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
PUBCHEM
10184665
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
MESH
C550468
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
NCI_THESAURUS
C152875
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
DRUG CENTRAL
4799
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
CHEBI
75037
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
WIKIPEDIA
Vilanterol
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
FDA UNII
028LZY775B
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
EVMPD
SUB77409
Created by admin on Fri Dec 15 17:40:33 GMT 2023 , Edited by admin on Fri Dec 15 17:40:33 GMT 2023
PRIMARY
Related Record Type Details
Structure of VILANTEROL TRIFENATATE
SALT/SOLVATE -> PARENT
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MAJOR
BETA-2 ADRENERGIC RECEPTOR
TARGET -> AGONIST
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
However, because of low oral bioavailability, inhibition of P-gp is unlikely to have an impact on the overall bioavailability of vilanterol.
Related Record Type Details
Structure of 5-((1R)-2-((6-(2-((2,6-DICHLOROPHENYL)METHOXY)ETHOXY)HEXYL)AMINO)-1-HYDROXYETHYL)-2-HYDROXYBENZOIC ACID
METABOLITE -> PARENT
PLASMA
Structure of GLYCINE, N-(6-(2-((2,6-DICHLOROPHENYL)METHOXY)ETHOXY)HEXYL)-
METABOLITE -> PARENT
URINE
Structure of 6-(2-((2,6-DICHLOROPHENYL)METHOXY)ETHOXY)HEXYLAMINE
METABOLITE -> PARENT
PLASMA
Structure of (2S,3S,4S,5R,6S)-6-(4-((1R)-2-(6-(CARBOXYMETHYLOXY)HEXYLAMINO)-1-HYDROXY-ETHYL)-2-(HYDROXYMETHYL)PHENOXY)-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID
METABOLITE -> PARENT
FECAL; PLASMA; URINE
Structure of GLYCINE, N-(6-(2-((2,6-DICHLOROPHENYL)METHOXY)ETHOXY)HEXYL)-
METABOLITE -> PARENT
PLASMA
Structure of 6-(((2R)-2-HYDROXY-2-(4-HYDROXY-3-(HYDROXYMETHYL)PHENYL)ETHYL)AMINO)HEXANOIC ACID
METABOLITE -> PARENT
FECAL; PLASMA; URINE
Structure of 6-(2-((2,6-DICHLOROPHENYL)METHOXY)ETHOXY)HEXYLAMINE
METABOLITE INACTIVE -> PARENT
human beta-2 cAMP LANCE assay (n=7-24), a value is mean pEC50 (-logEC50); Vilanterol's beta-2 activity is 10.4 (pEC50)
IN-VITRO
Structure of .BETA.-D-GLUCOPYRANOSIDURONIC ACID, 4-((1R)-2-((5-CARBOXYPENTYL)AMINO)-1-HYDROXYETHYL)-2-(HYDROXYMETHYL)PHENYL
METABOLITE -> PARENT
URINE
Structure of GW-630200
METABOLITE -> PARENT
FECAL; PLASMA; URINE
Structure of GSK-932009
METABOLITE -> PARENT
FECAL
Structure of 2-HYDROXY-5-((1R)-1-HYDROXY-2-((6-HYDROXY-6-OXO-HEXYL)AMINO)ETHYL)BENZOIC ACID
METABOLITE -> PARENT
FECAL; PLASMA; URINE
Structure of .BETA.-D-GLUCOPYRANOSIDURONIC ACID, 4-((1R)-2-((5-CARBOXYPENTYL)AMINO)-1-HYDROXYETHYL)-2-(HYDROXYMETHYL)PHENYL
METABOLITE -> PARENT
PLASMA
Structure of GSK-932009
METABOLITE -> PARENT
URINE
Structure of .BETA.-D-GLUCOPYRANOSIDURONIC ACID, 4-((1R)-1-HYDROXY-2-((6-(2-HYDROXYETHOXY)HEXYL)AMINO)ETHYL)-2-(HYDROXYMETHYL)PHENYL
METABOLITE -> PARENT
URINE
Structure of 6-(2-((2,6-DICHLOROPHENYL)METHOXY)ETHOXY)HEXYLAMINE
METABOLITE -> PARENT
URINE
Structure of GSK-932009
METABOLITE INACTIVE -> PARENT
human beta-1 cAMP LANCE assay (n=7-24), a value is mean pEC50 (-logEC50); Vilanterol's beta-1 activity is 7.0 (pEC50)
IN-VITRO
Related Record Type Details
Structure of VILANTEROL
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC INTRAVENOUS ADMINISTRATION

blood-to-plasma ratio PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC INTRAVENOUS ADMINISTRATION

NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966