GUANOSINE TRIPHOSPHATE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H16N5O14P3
Molecular Weight	523.1804
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC2=C(N=CN2[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

InChIKey=XKMLYUALXHKNFT-UUOKFMHZSA-N

InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H16N5O14P3
Molecular Weight	523.1804
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
UMP-CMP kinase 5 Target ID: CHEMBL5681 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8573186	Substrate 661
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 5 Target ID: Q9Y3Z3 Gene ID: 25939.0 Gene Symbol: SAMHD1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/23880768	Activator 1430
Ras-like GTPases 5 Target ID: Ras-like GTPases Sources: https://www.ncbi.nlm.nih.gov/pubmed/15236956	Substrate 661

PubMed

Title	Date	PubMed
[Mechanism of the activating action of guanosine triphosphate (GTP) on the fat oxidazing enzyme system. IV].	1959 Feb 15	13639918
[Guanosine triphosphate activation of enzyme systems of fatty acid oxidation. III].	1959 Jan 15	13619678
Phosphoenolpyruvate carboxykinase (guanosine triphosphate) from rat liver cytosol. Separation of homogeneous forms of the enzyme with high and low activity by chromatography on agarose-hexane-guanosine triphosphate.	1978 Dec 12	728402
GTP is the primary activator of the anti-HIV restriction factor SAMHD1.	2013 Aug 30	23880768
GTP and ATP hydrolysis in biology.	2016 Aug	27135900

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:29:02 UTC 2023` Edited by `admin` on `Sat Dec 16 11:29:02 UTC 2023`
Record UNII	01WV7J708X
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

GUANOSINE TRIPHOSPHATE

Systematic Name

English

GUANOSINE-5'-TRIPHOSPHATE

Systematic Name

English

5'-GTP

Common Name

English

GUANOSINE 5'-(TETRAHYDROGEN TRIPHOSPHATE)

Systematic Name

English

GUANOSINE 5'-TRIPHOSPHATE

Systematic Name

English

GTP

Common Name

English

GUANOSINE 5'-TRIPHOSPHORIC ACID

Common Name

English

Code System Code Type Description

CHEBI

15996