Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H24N2OS |
| Molecular Weight | 340.482 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(=O)C1=CC2=C(SC3=C(C=CC=C3)N2CCCN(C)C)C=C1
InChI
InChIKey=ZQTVCQIJTREKSP-UHFFFAOYSA-N
InChI=1S/C20H24N2OS/c1-4-18(23)15-10-11-20-17(14-15)22(13-7-12-21(2)3)16-8-5-6-9-19(16)24-20/h5-6,8-11,14H,4,7,12-13H2,1-3H3
Propionylpromazine is used as a neuroleptic to combat stress in pets and farm animals. The main use is to combat stress in the transport of pigs. Propionylpromazine was in common use in veterinary practice in the 1950s and 1960s. Propionylpromazine is of interest to JECFA because of the illicit use at pharmacological dosage (< 1 mg/kg i.m.) in the immediate pre-slaughter period.
CNS Activity
Sources: http://www.sigmaaldrich.com/catalog/product/sigma/p7780?lang=en®ion=RUhttp://www.fao.org/fileadmin/user_upload/vetdrug/docs/41-4-propionylpromazine.pdf
Curator's Comment: D2 dopamine receptor antagonist; phenothiazine antipsychotic.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL5131 |
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Target ID: CHEMBL5131 |
357.0 µM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Propiopromazine Approved UseIndications for use. For oral administration as a tranquilizer. As an aid in handling difficult, excited, and unruly dogs, and in controlling excessive kennel barking, car sickness, and severe dermatitis. It is also indicated for use in minor surgery and prior to routine examinations, laboratory procedures, and diagnostic procedures. |
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| Primary | TRANVET Approved UsePropionylpromazine is used as a neuroleptic to combat stress in pets and farm animals. The main use is to combat stress in the transport of pigs. Launch Date1960 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of electroanesthesia and a phenothiazine tranquilizer on thermoregulation in the sheep. | 1977 Mar |
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| [Effect of phenothiazine derivative on adrenal cortex response of sheep to repeated emotional stress]. | 1991 |
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| [Hepatic resection in the fetal rabbit. Histologic comparison of tissue regeneration in the fetus versus the adult]. | 1996 Nov |
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| Retrospective evaluation of cardiopulmonary and acid-base variables during long-term balanced anesthesia for experimental surgery in dogs. | 1997 Dec |
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| Gas chromatographic-mass spectrometric analysis of veterinary tranquillizers in urine: evaluation of method performance. | 1999 Oct 29 |
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| Trypanosoma cruzi trypanothione reductase is inactivated by peroxidase-generated phenothiazine cationic radicals. | 2001 Apr |
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| Spectrophotometric determination of vanadium(V) in minerals, steels, soil and biological samples using phenothiazine derivatives. | 2001 Aug |
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| [The opinion of O. Habler]. | 2001 Aug |
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| [Acute normovolemic hemodilution (ANH). Der Anaesthesist (2000) 49: 939-948]. | 2001 Aug |
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| [Inactivation of Trypanosoma cruzi trypanothione reductase by phenothiazine cationic free radicals]. | 2001 Jan-Mar |
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| Analysis of promazines in bovine livers by high performance liquid chromatography with ultraviolet and fluorimetric detection. | 2003 Feb 6 |
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| Development of a rapid screening test for veterinary sedatives and the beta-blocker carazolol in porcine kidney by ELISA. | 2004 Feb |
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| Stability of the tranquilizer drug propionylpromazine hydrochloride in formulated products. | 2005 Jun |
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| Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS. | 2008 Jul |
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| Rapid method for the determination of tranquilizers and a beta-blocker in porcine and bovine kidney by liquid chromatography with tandem mass spectrometry. | 2009 Apr 1 |
|
| Effects of inosine on reperfusion injury after cardiopulmonary bypass. | 2010 Nov 8 |
Sample Use Guides
Dogs: Administer 0.5 to 2.0 milligrams per pound of body weight once or twice daily, depending upon the degree of tranquilization desired.
Route of Administration:
Oral
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29710
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CFR |
21 CFR 520.2002
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admin on Fri Dec 15 16:20:02 GMT 2023 , Edited by admin on Fri Dec 15 16:20:02 GMT 2023
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3568-24-9
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300000031240
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C026328
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DTXSID3046950
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24352
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DB11540
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m9213
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222-662-1
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Y1BCT334I7
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C84113
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)
