FOSDENOPTERIN HYDROBROMIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H14N5O8P.BrH.2H2O
Molecular Weight	480.163
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O.Br.[H][C@@]12COP(O)(=O)O[C@]1([H])C(O)(O)[C@]3([H])NC4=C(N[C@]3([H])O2)N=C(N)NC4=O

InChI

InChIKey=GGLKTKQOHMCQHF-UNHNTEMGSA-N

InChI=1S/C10H14N5O8P.BrH.2H2O/c11-9-14-6-3(7(16)15-9)12-4-8(13-6)22-2-1-21-24(19,20)23-5(2)10(4,17)18;;;/h2,4-5,8,12,17-18H,1H2,(H,19,20)(H4,11,13,14,15,16);1H;2*1H2/t2-,4-,5+,8-;;;/m1.../s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15115759 | https://www.ncbi.nlm.nih.gov/pubmed/26343839

Cyclic pyranopterin monophosphate is a precursor to molybdenum cofactor, which is required for the enzyme activity of sulfite oxidase, xanthine dehydrogenase/oxidase, and aldehyde oxidase. The drug is being investigated in severe molybdenum cofactor deficiency type A. In a clinical study, intravenous administration of the drug resulted in greatly improved neurodevelopmental outcome when started sufficiently early.

Approval Year

Name

Type

Language

FOSDENOPTERIN HYDROBROMIDE

Official Name

English

NULIBRY

Brand Name

English

ALXN-1101 HYDROBROMIDE DIHYDRATE

Code

English

FOSDENOPTERIN HYDROBROMIDE [USAN]

Common Name

English

CYCLIC PYRANOPTERIN MONOPHOSPHATE MONOHYDROBROMIDE DIHYDRATE

Common Name

English

FOSDENOPTERIN HYDROBROMIDE [ORANGE BOOK]

Common Name

English

FOSDENOPTERIN HYDROBROMIDE DIHYDRATE

Common Name

English

1,3,2-DIOXAPHOSPHORINO(4',5':5,6)PYRANO(3,2-G)PTERIDIN-10(4H)-ONE, 8-AMINO-4A,5A,6,9,11,11A,12,12A-OCTAHYDRO-2,12,12-TRIHYDROXY-, 2-OXIDE, HYDROBROMIDE, HYDRATE (1:1:2), (4AR,5AR,11AR,12AS)-

Systematic Name

English

Fosdenopterin hydrobromide dihydrate [WHO-DD]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C174941