FOSDENOPTERIN HYDROBROMIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H14N5O8P.BrH.2H2O
Molecular Weight	480.163
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O.Br.[H][C@@]12COP(O)(=O)O[C@]1([H])C(O)(O)[C@]3([H])NC4=C(N[C@]3([H])O2)N=C(N)NC4=O

InChI

InChIKey=GGLKTKQOHMCQHF-UNHNTEMGSA-N

InChI=1S/C10H14N5O8P.BrH.2H2O/c11-9-14-6-3(7(16)15-9)12-4-8(13-6)22-2-1-21-24(19,20)23-5(2)10(4,17)18;;;/h2,4-5,8,12,17-18H,1H2,(H,19,20)(H4,11,13,14,15,16);1H;2*1H2/t2-,4-,5+,8-;;;/m1.../s1

HIDE SMILES / InChI

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	BrH
Molecular Weight	80.912
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C10H14N5O8P
Molecular Weight	363.2206
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15115759 | https://www.ncbi.nlm.nih.gov/pubmed/26343839

Cyclic pyranopterin monophosphate is a precursor to molybdenum cofactor, which is required for the enzyme activity of sulfite oxidase, xanthine dehydrogenase/oxidase, and aldehyde oxidase. The drug is being investigated in severe molybdenum cofactor deficiency type A. In a clinical study, intravenous administration of the drug resulted in greatly improved neurodevelopmental outcome when started sufficiently early.

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 19:07:30 GMT 2023` Edited by `admin` on `Sat Dec 16 19:07:30 GMT 2023`
Record UNII	X41B5W735T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FOSDENOPTERIN HYDROBROMIDE

Official Name

English

NULIBRY

Brand Name

English

ALXN-1101 HYDROBROMIDE DIHYDRATE

Code

English

FOSDENOPTERIN HYDROBROMIDE [USAN]

Common Name

English

CYCLIC PYRANOPTERIN MONOPHOSPHATE MONOHYDROBROMIDE DIHYDRATE

Common Name

English

FOSDENOPTERIN HYDROBROMIDE [ORANGE BOOK]

Common Name

English

FOSDENOPTERIN HYDROBROMIDE DIHYDRATE

Common Name

English

1,3,2-DIOXAPHOSPHORINO(4',5':5,6)PYRANO(3,2-G)PTERIDIN-10(4H)-ONE, 8-AMINO-4A,5A,6,9,11,11A,12,12A-OCTAHYDRO-2,12,12-TRIHYDROXY-, 2-OXIDE, HYDROBROMIDE, HYDRATE (1:1:2), (4AR,5AR,11AR,12AS)-

Systematic Name

English

Fosdenopterin hydrobromide dihydrate [WHO-DD]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C174941