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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H14N5O8P.BrH.2H2O
Molecular Weight 480.163
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FOSDENOPTERIN HYDROBROMIDE

SMILES

O.O.Br.[H][C@@]12COP(O)(=O)O[C@]1([H])C(O)(O)[C@]3([H])NC4=C(N[C@]3([H])O2)N=C(N)NC4=O

InChI

InChIKey=GGLKTKQOHMCQHF-UNHNTEMGSA-N
InChI=1S/C10H14N5O8P.BrH.2H2O/c11-9-14-6-3(7(16)15-9)12-4-8(13-6)22-2-1-21-24(19,20)23-5(2)10(4,17)18;;;/h2,4-5,8,12,17-18H,1H2,(H,19,20)(H4,11,13,14,15,16);1H;2*1H2/t2-,4-,5+,8-;;;/m1.../s1

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula BrH
Molecular Weight 80.912
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C10H14N5O8P
Molecular Weight 363.2206
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Cyclic pyranopterin monophosphate is a precursor to molybdenum cofactor, which is required for the enzyme activity of sulfite oxidase, xanthine dehydrogenase/oxidase, and aldehyde oxidase. The drug is being investigated in severe molybdenum cofactor deficiency type A. In a clinical study, intravenous administration of the drug resulted in greatly improved neurodevelopmental outcome when started sufficiently early.

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 19:07:30 UTC 2023
Edited
by admin
on Sat Dec 16 19:07:30 UTC 2023
Record UNII
X41B5W735T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FOSDENOPTERIN HYDROBROMIDE
USAN  
Official Name English
NULIBRY
Brand Name English
ALXN-1101 HYDROBROMIDE DIHYDRATE
Code English
FOSDENOPTERIN HYDROBROMIDE [USAN]
Common Name English
CYCLIC PYRANOPTERIN MONOPHOSPHATE MONOHYDROBROMIDE DIHYDRATE
Common Name English
FOSDENOPTERIN HYDROBROMIDE [ORANGE BOOK]
Common Name English
FOSDENOPTERIN HYDROBROMIDE DIHYDRATE
Common Name English
1,3,2-DIOXAPHOSPHORINO(4',5':5,6)PYRANO(3,2-G)PTERIDIN-10(4H)-ONE, 8-AMINO-4A,5A,6,9,11,11A,12,12A-OCTAHYDRO-2,12,12-TRIHYDROXY-, 2-OXIDE, HYDROBROMIDE, HYDRATE (1:1:2), (4AR,5AR,11AR,12AS)-
Systematic Name English
Fosdenopterin hydrobromide dihydrate [WHO-DD]
Common Name English
Code System Code Type Description
NCI_THESAURUS
C174941
Created by admin on Sat Dec 16 19:07:30 UTC 2023 , Edited by admin on Sat Dec 16 19:07:30 UTC 2023
PRIMARY
CAS
2301083-34-9
Created by admin on Sat Dec 16 19:07:30 UTC 2023 , Edited by admin on Sat Dec 16 19:07:30 UTC 2023
PRIMARY
PUBCHEM
145722612
Created by admin on Sat Dec 16 19:07:30 UTC 2023 , Edited by admin on Sat Dec 16 19:07:30 UTC 2023
PRIMARY
DAILYMED
X41B5W735T
Created by admin on Sat Dec 16 19:07:30 UTC 2023 , Edited by admin on Sat Dec 16 19:07:30 UTC 2023
PRIMARY
SMS_ID
100000182873
Created by admin on Sat Dec 16 19:07:30 UTC 2023 , Edited by admin on Sat Dec 16 19:07:30 UTC 2023
PRIMARY
EVMPD
SUB197141
Created by admin on Sat Dec 16 19:07:30 UTC 2023 , Edited by admin on Sat Dec 16 19:07:30 UTC 2023
PRIMARY
FDA UNII
X41B5W735T
Created by admin on Sat Dec 16 19:07:30 UTC 2023 , Edited by admin on Sat Dec 16 19:07:30 UTC 2023
PRIMARY
USAN
GH-136
Created by admin on Sat Dec 16 19:07:30 UTC 2023 , Edited by admin on Sat Dec 16 19:07:30 UTC 2023
PRIMARY
RXCUI
2531287
Created by admin on Sat Dec 16 19:07:30 UTC 2023 , Edited by admin on Sat Dec 16 19:07:30 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
ANHYDROUS->SOLVATE
Related Record Type Details
ACTIVE MOIETY