SODIUM URATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H3N4O3.Na
Molecular Weight	190.0921
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].O=C1NC2=C(N1)C(=O)[N-]C(=O)N2

InChI

InChIKey=NAFSTSRULRIERK-UHFFFAOYSA-M

InChI=1S/C5H4N4O3.Na/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;/h(H4,6,7,8,9,10,11,12);/q;+1/p-1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25422986
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/dict/uric-acid.html | http://www.wikidoc.org/index.php/Uric_acid

Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Humans produce large quantities of uric acid. Excess serum accumulation of uric acid can lead to a type of arthritis known as gout. Hyperuricemia may increase risk factors for cardiovascular disease. High serum uric acid was associated with higher risk of type 2 diabetes and other diseases.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Urate oxidase (mammals) 3 Target ID: Urate oxidase (mammals) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2594778	Substrate 661

Conditions

Condition	Modality	Highest Phase	Product
Multiple sclerosis 104 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23528410 https://www.ncbi.nlm.nih.gov/pubmed/11985629	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown
Type 2 diabetes mellitus 259 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17977935	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown
Cardiovascular diseases 71 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25192804	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Copper and zinc concentrations and the activities of ceruloplasmin and superoxide dismutase in atherosclerosis obliterans.	2000 Jan	10949969
Is skeletal muscle damaged by the oxidative stress following anaerobic exercise?	2001	11574951
Inflammatory microcrystals induce murine macrophage survival and DNA synthesis.	2001	11438042
Rasburicase.	2001	11437188
Influence quantities and uncertainty of measurement.	2001	11427474
Prostaglandin inhibition by intraperitoneal indomethacin has no effect on peritoneal permeability during stable CAPD.	2001 Apr	11274278
The potential role of adenosine in the pathophysiology of the insulin resistance syndrome.	2001 Apr	11254897
Flow-through chemiluminescence sensor using immobilized oxidases for the selective determination of L-glutamate in a flow-injection system.	2001 Aug	11708095
Plasma concentrations of alpha-tocopherol and urate in patients with different types of cancer.	2001 Aug	11493368
Laryngeal manifestation of gout: a case report of a subglottic gout tophus.	2001 Aug	11489374
Uric acid or urate nephropathy?	2001 Aug	11479177
Biochemical profile of idiopathic uric acid nephrolithiasis.	2001 Aug	11473659
Experimental meningitis in the rat: protection by uric acid at human physiological blood concentrations.	2001 Aug 10	11502281
The cyclooxygenase hydroperoxide product PGG(2) activates synaptic nitric oxide synthase: a possible antioxidant response to membrane lipid peroxidation.	2001 Aug 17	11500026
Recurrent renal stone disease-advances in pathogenesis and clinical management.	2001 Aug 25	11530173
Water-soluble antioxidants in human tears: effect of the collection method.	2001 Dec	11726613
Oxidative stress in lavage fluid of preterm infants at risk of chronic lung disease.	2001 Dec	11704534
The effect of trimethoprim on potassium and uric acid metabolism in normal human subjects.	2001 Jan	11200867
Role of exercise and ascorbate on plasma antioxidant capacity in thoroughbred race horses.	2001 Jan	11137442
Risk factors for coronary heart disease in obese non-diabetic subjects.	2001 Jul	11443504
Iron(III)-mediated intra-articular crystal deposition in arthritis: a therapeutic role for iron chelators.	2001 Jul	11421639
Immunological properties of uricase conjugated to neutral soluble polymers.	2001 Jul-Aug	11459455
Pathways for urea production during early life of an air-breathing teleost, the African catfish Clarias gariepinus Burchell.	2001 Jun	11441057
Evidence for alterations in circulating low-molecular-weight antioxidants and increased lipid peroxidation in smokers on hemodialysis.	2001 Jun	11399914
Renal regulation of plasma total antioxidant capacity.	2001 Jun	11399110
Partially reversible renal tubular damage in patients with obstructive jaundice.	2001 Jun	11391524
Cystine calculi in children: the results of a metabolic evaluation and response to medical therapy.	2001 Jun	11371943
Hyperuricemia and renal function.	2001 Jun	11353569
[Relationship between severity of essential arterial hypertension and the prevalence hyperuricemia].	2001 Jun 23	11459575
Contribution of peroxynitrite to the beneficial effects of preconditioning on ischaemia-induced arrhythmias in rat isolated hearts.	2001 Mar	11275005
Ureteropelvic junction obstruction and coexisting renal calculi in children: role of metabolic abnormalities.	2001 Mar	11248635
Dehydroascorbic acid and oxidative stress in haemodialysis patients.	2001 Mar	11239034
Binding of urate and caffeine to haemocyanin analysed by isothermal titration calorimetry.	2001 Mar	11171426
Flavonoids and urate antioxidant interplay in plasma oxidative stress.	2001 May	11506190
Uric acid and cardiovascular disease: a renal-cardiac relationship?	2001 May	11342800
Functional reconstitution, membrane targeting, genomic structure, and chromosomal localization of a human urate transporter.	2001 May	11342574
Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase.	2001 May	11316859
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.	2001 May	11306713
A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis.	2001 May 15	11342423
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.	2001 Nov	11711505
Respiratory and circulatory compensation to hypoxia in crustaceans.	2001 Nov 15	11718763
Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase.	2001 Nov 16	11700027
Urate oxidase in the prophylaxis or treatment of hyperuricemia: the United States experience.	2001 Oct	11694947
Ozone causes lipid peroxidation but little antioxidant depletion in exercising and nonexercising hamsters.	2001 Oct	11568152
A family-based study of metabolic phenotypes in calcium urolithiasis.	2001 Sep	11532110
Suicide inactivation of xanthine oxidoreductase during reduction of inorganic nitrite to nitric oxide.	2001 Sep 1	11513730
Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite.	2002 Jan	11788457

Patents

Sample Use Guides

In Vivo Use Guide

Mice: twice daily with 10 mg per dose for 7 days

Route of Administration: Intraperitoneal

In Vitro Use Guide

Uric acid (5 mg/dL) significantly increased MCP-1 production by rat vascular smooth muscle cells at 3, 6, and 24 hours when compared with that of control media.

Name

Type

Language

SODIUM URATE

Common Name

English

1H-PURINE-2,6,8(3H)-TRIONE, 7,9-DIHYDRO-, SODIUM SALT (1:1)

Systematic Name

English

MONOSODIUM URATE

Common Name

English

URIC ACID, MONOSODIUM SALT

Common Name

English

Classification Tree Code System Code

LOINC

54437-9