ETHACRIDINE LACTATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H15N3O.C3H6O3.H2O
Molecular Weight	361.3923
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.CC(O)C(O)=O.CCOC1=CC2=C(N)C3=CC=C(N)C=C3N=C2C=C1

InChI

InChIKey=NYEPHMYJRNWPLA-UHFFFAOYSA-N

InChI=1S/C15H15N3O.C3H6O3.H2O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6;/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6);1H2

HIDE SMILES / InChI

Description
Sources: http://link.springer.com/chapter/10.1007/978-94-011-6678-2_9
Curator's Comment: description was created based on several sources, including, www.ncbi.nlm.nih.gov/pubmed/17294498, http://www.chemaxpharma.com/en/rivanol-chemax-pharma-0-1

Ethacridine (Rivanol) is an acridine derivative indicated for the treatment of bacterial infections. In many countries the drug was in clinical practice for the second trimester termination of pregnancy.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bacterial infections 235 Sources: http://www.chemaxpharma.com/en/rivanol-chemax-pharma-0-1	Curative		Approved 8583	RIVANOL Approved Use Antiseptic for external treatment of superficial incised wounds and operational wounds, ulcers of the skin, pyoderma, secondarily infected dermatoses, burns.

Doses

Dose	Population	Adverse events
200 mL single, intrauterine Recommended Dose: 200 mL Route: intrauterine Route: single Dose: 200 mL Sources: https://pubmed.ncbi.nlm.nih.gov/9292644/	pregnant, ADULT Health Status: pregnant Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/9292644/	Sources: https://pubmed.ncbi.nlm.nih.gov/9292644/

PubMed

Title	Date	PubMed
Hemodialysis vascular access options in pediatrics: considerations for patients and practitioners.	2009-06	18392860
Effects of the selective serotonin reuptake inhibitor fluoxetine on counterregulatory responses to hypoglycemia in individuals with type 1 diabetes.	2008-12	18835927
Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensing.	2008-10	18519802
The design, development, and evaluation of a prototypic, prosthetic venous valve.	2008-09-19	18803829
Genomics, molecular imaging, bioinformatics, and bio-nano-info integration are synergistic components of translational medicine and personalized healthcare research.	2008-09-16	18831773
Effects of a selective serotonin reuptake inhibitor, fluoxetine, on counterregulatory responses to hypoglycemia in healthy individuals.	2008-09	18567822
Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.	2008-08-22	18725925
Mixtures of quaternary ammonium compounds and anionic organic compounds in the aquatic environment: Elimination and biodegradability in the closed bottle test monitored by LC-MS/MS.	2008-06	18439651
Sticky gecko feet: the role of temperature and humidity.	2008-05-14	18478106
Misoprostol preferable to ethacridine lactate for abortions at 13-20 weeks of pregnancy: Cuban experience.	2008-05	18772100
Second trimester abortions in India.	2008-05	18772082
Brisk walking compared with an individualised medical fitness programme for patients with type 2 diabetes: a randomised controlled trial.	2008-05	18297259
Strain-specific virulence phenotypes of Streptococcus pneumoniae assessed using the Chinchilla laniger model of otitis media.	2008-04-09	18398481
The Cuyahoga is still burning.	2008-04	18414602
Testosterone influences renal electrolyte excretion in SHR/y and WKY males.	2008-03-26	18366771
A 12 week, open label, phase I/IIa study using apatone for the treatment of prostate cancer patients who have failed standard therapy.	2008-03-24	18392145
A laparoscopic simulator tool for objective measurement of residents' laparoscopic ability.	2008-02-02	18237513
Antibiotics and antiseptics for venous leg ulcers.	2008-01-23	18254024
Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration.	2008	18625036
Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole.	2008	18615197
The Akron dome midfoot osteotomy as a salvage procedure for the treatment of rigid pes cavus: a retrospective review.	2007-12-25	18157049
Is mechanism of injury alone in the prehospital setting a predictor of major trauma - a review of the literature.	2007-11-26	18271994
Nodal signaling is required for closure of the anterior neural tube in zebrafish.	2007-11-08	17996054
Modeling and detection of respiratory-related outbreak signatures.	2007-10-05	17919318
Double blind, randomized, placebo controlled clinical trial for the treatment of diabetic foot ulcers, using a nitric oxide releasing patch: PATHON.	2007-09-26	17897470
The organizational effects of oxytocin on the central expression of estrogen receptor alpha and oxytocin in adulthood.	2007-09-07	17825097
Effects of interpregnancy interval and outcome of the preceding pregnancy on pregnancy outcomes in Matlab, Bangladesh.	2007-09	17617195
Phylogenetic review of tonal sound production in whales in relation to sociality.	2007-08-10	17692128
Left-sided gallbladder (sinistroposition) with duplication of the common bile duct.	2007-07-27	17651579
Physiologically-based testing system for the mechanical characterization of prosthetic vein valves.	2007-07-13	17629916
L5-S1 laparoscopic anterior interbody fusion.	2007-06-20	17575763
Baseline characteristics influencing quality of life in women undergoing gynecologic oncology surgery.	2007-05-17	17509145
A cell culture model using rat coronary artery adventitial fibroblasts to measure collagen production.	2007-05-08	17488510
An HPLC method for the determination of ethacridine lactate in human urine.	2007-05	17294498
Genetic mapping of a new heart rate QTL on chromosome 8 of spontaneously hypertensive rats.	2007-04-09	17419875
Genomic and expression analysis of multiple Sry loci from a single Rattus norvegicus Y chromosome.	2007-04-04	17408480
Construct validity of the endoscopic sinus surgery simulator: II. Assessment of discriminant validity and expert benchmarking.	2007-04	17438249
Silent rupture of unscarred uterus: an unusual presentation at second trimester abortion.	2007-04	16957913
Stimulation of MAP kinase pathways after maternal IL-1beta exposure induces fetal lung fluid absorption in guinea pigs.	2007-03-26	17386088
Outcomes of decompression for lumbar spinal canal stenosis based upon preoperative radiographic severity.	2007-03-08	17346339
Sry delivery to the adrenal medulla increases blood pressure and adrenal medullary tyrosine hydroxylase of normotensive WKY rats.	2007-02-26	17324261
Sex differences in judging self-orientation: the morphological horizon and body pitch.	2007-01-07	17207289
[Value of estrogen for preventing postpartum hemorrhage and shortening birth process in induce abortion].	2007-01	17259157
The relationship between protein sequences and their gene ontology functions.	2006-12-12	17217503
Myocardial performance in conscious streptozotocin diabetic rats.	2006-12-04	17144912
The association between indwelling urinary catheter use in the elderly and urinary tract infection in acute care.	2006-10-12	17038177
Effects of tamoxifen on vaginal blood flow and epithelial morphology in the rat.	2006-09-13	16970814
Substance abuse prevention infrastructure: a survey-based study of the organizational structure and function of the D.A.R.E. program.	2006-09-06	16956400
Protein and overtraining: potential applications for free-living athletes.	2006-06-05	18500962
Community coalitions and prevention: a panel discussion.	2004-08	18552735

Patents

Sample Use Guides

In Vivo Use Guide

Apply 0,1 % cutaneous solution to the affected area of skin.

Route of Administration: Topical

In Vitro Use Guide

Ethacridine shows weak becteriostatic activity against gram-positive bacteria with MIC 1-10 ug/ml.

Name

Type

Language

ETHACRIDINE LACTATE

Common Name

English

ACRINOL HYDRATE

Preferred Name

English

Ethacridine lactate monohydrate [WHO-DD]

Common Name

English

VUCINE

Brand Name

English

METIFEX

Brand Name

English

6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE MONOHYDRATE

Systematic Name

English

ACRINOL HYDRATE [JAN]

Common Name

English

RIVANOL

Brand Name

English

ETHACRIDINE LACTATE MONOHYDRATE [EP MONOGRAPH]

Common Name

English

ETHODIN

Brand Name

English

ETHACRIDINE LACTATE [MART.]

Common Name

English

ETHACRIDINE LACTATE MONOHYDRATE [EP IMPURITY]

Common Name

English

PROPANOIC ACID, 2-HYDROXY-, COMPD. WITH 7-ETHOXY-3,9-ACRIDINEDIAMINE, HYDRATE (1:1:1)

Common Name

English

ETHACRIDINE LACTATE MONOHYDRATE [MI]

Common Name

English

RIMAON

Brand Name

English

ACROLACTIN

Brand Name

English

ANTIDIAR 200

Brand Name

English

Classification Tree Code System Code

WHO-ATC

D08AA01