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Primary Target

Bacterial dihydropteroate synthase

3

Dihydropteroate synthetase

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Serine/threonine-protein kinase Aurora-A

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Acridine derivatives

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SULFADIAZINE

0N7609K889

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Status:

US Approved Rx (1994)

First approved in 1941

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Toxoplasma gondii

Escherichia coli

Serine/threonine-protein kinase Aurora-A

Bacterial dihydropteroate synthase

Dihydropteroate synthetase

Conditions:

Toxoplasmosis encephalitis

Urinary tract infections

Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sul...

fonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus. Sulfadiazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. Used for the treatment of rheumatic fever and meningococcal meningitis.

ETHACRIDINE

WIX85M1A6R

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Status:

Possibly Marketed Outside US

First approved in 2015

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

Bacterial infections

Ethacridine (Rivanol) is an acridine derivative indicated for the treatment of bacterial infections. In many countries the drug was in clinical practice for the second trimester termination of pregnancy.

SULFADIAZINE SODIUM

84CS1P306F

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Status:

US Approved Rx (1994)

First approved in 1941

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Toxoplasma gondii

Escherichia coli

Serine/threonine-protein kinase Aurora-A

Bacterial dihydropteroate synthase

Dihydropteroate synthetase

Conditions:

Toxoplasmosis encephalitis

Urinary tract infections

Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sul...

fonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus. Sulfadiazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. Used for the treatment of rheumatic fever and meningococcal meningitis.

SULFADIAZINE ZINC

5FE7HP0JMG

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Status:

US Approved Rx (1994)

First approved in 1941

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Toxoplasma gondii

Escherichia coli

Serine/threonine-protein kinase Aurora-A

Bacterial dihydropteroate synthase

Dihydropteroate synthetase

Conditions:

Toxoplasmosis encephalitis

Urinary tract infections

Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sul...

fonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus. Sulfadiazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. Used for the treatment of rheumatic fever and meningococcal meningitis.

ETHACRIDINE LACTATE ANHYDROUS

7T7T2I9823

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Status:

Possibly Marketed Outside US

First approved in 2015

Class (Stereo):

CHEMICAL (RACEMIC)

Conditions:

Bacterial infections

Ethacridine (Rivanol) is an acridine derivative indicated for the treatment of bacterial infections. In many countries the drug was in clinical practice for the second trimester termination of pregnancy.

ETHACRIDINE LACTATE

V5IL571C1T

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Status:

Possibly Marketed Outside US

First approved in 2015

Class (Stereo):

CHEMICAL (RACEMIC)

Conditions:

Bacterial infections

Ethacridine (Rivanol) is an acridine derivative indicated for the treatment of bacterial infections. In many countries the drug was in clinical practice for the second trimester termination of pregnancy.

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