ETHACRIDINE LACTATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H15N3O.C3H6O3.H2O
Molecular Weight	361.3923
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.CC(O)C(O)=O.CCOC1=CC2=C(C=C1)N=C3C=C(N)C=CC3=C2N

InChI

InChIKey=NYEPHMYJRNWPLA-UHFFFAOYSA-N

InChI=1S/C15H15N3O.C3H6O3.H2O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6;/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6);1H2

HIDE SMILES / InChI

Molecular Formula	C15H15N3O
Molecular Weight	253.2991
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C3H6O3
Molecular Weight	90.0779
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://link.springer.com/chapter/10.1007/978-94-011-6678-2_9
Curator's Comment: description was created based on several sources, including, www.ncbi.nlm.nih.gov/pubmed/17294498, http://www.chemaxpharma.com/en/rivanol-chemax-pharma-0-1

Ethacridine (Rivanol) is an acridine derivative indicated for the treatment of bacterial infections. In many countries the drug was in clinical practice for the second trimester termination of pregnancy.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bacterial infections 234 Sources: http://www.chemaxpharma.com/en/rivanol-chemax-pharma-0-1	Curative		Approved 8429	RIVANOL Approved Use Antiseptic for external treatment of superficial incised wounds and operational wounds, ulcers of the skin, pyoderma, secondarily infected dermatoses, burns.

PubMed

Title	Date	PubMed
Community coalitions and prevention: a panel discussion.	2004 Aug	18552735
The relationship between protein sequences and their gene ontology functions.	2006 Dec 12	17217503
Myocardial performance in conscious streptozotocin diabetic rats.	2006 Dec 4	17144912
Protein and overtraining: potential applications for free-living athletes.	2006 Jun 5	18500962
The association between indwelling urinary catheter use in the elderly and urinary tract infection in acute care.	2006 Oct 12	17038177
L5-S1 laparoscopic anterior interbody fusion.	2006 Oct-Dec	17575763
Effects of tamoxifen on vaginal blood flow and epithelial morphology in the rat.	2006 Sep 13	16970814
Substance abuse prevention infrastructure: a survey-based study of the organizational structure and function of the D.A.R.E. program.	2006 Sep 6	16956400
Construct validity of the endoscopic sinus surgery simulator: II. Assessment of discriminant validity and expert benchmarking.	2007 Apr	17438249
Silent rupture of unscarred uterus: an unusual presentation at second trimester abortion.	2007 Apr	16957913
Genomic and expression analysis of multiple Sry loci from a single Rattus norvegicus Y chromosome.	2007 Apr 4	17408480
Genetic mapping of a new heart rate QTL on chromosome 8 of spontaneously hypertensive rats.	2007 Apr 9	17419875
Phylogenetic review of tonal sound production in whales in relation to sociality.	2007 Aug 10	17692128
Sry delivery to the adrenal medulla increases blood pressure and adrenal medullary tyrosine hydroxylase of normotensive WKY rats.	2007 Feb 26	17324261
[Value of estrogen for preventing postpartum hemorrhage and shortening birth process in induce abortion].	2007 Jan	17259157
Sex differences in judging self-orientation: the morphological horizon and body pitch.	2007 Jan 7	17207289
Left-sided gallbladder (sinistroposition) with duplication of the common bile duct.	2007 Jan-Mar	17651579
Physiologically-based testing system for the mechanical characterization of prosthetic vein valves.	2007 Jul 13	17629916
Stimulation of MAP kinase pathways after maternal IL-1beta exposure induces fetal lung fluid absorption in guinea pigs.	2007 Mar 26	17386088
Outcomes of decompression for lumbar spinal canal stenosis based upon preoperative radiographic severity.	2007 Mar 8	17346339
An HPLC method for the determination of ethacridine lactate in human urine.	2007 May	17294498
Baseline characteristics influencing quality of life in women undergoing gynecologic oncology surgery.	2007 May 17	17509145
A cell culture model using rat coronary artery adventitial fibroblasts to measure collagen production.	2007 May 8	17488510
Is mechanism of injury alone in the prehospital setting a predictor of major trauma - a review of the literature.	2007 Nov 26	18271994
Nodal signaling is required for closure of the anterior neural tube in zebrafish.	2007 Nov 8	17996054
Modeling and detection of respiratory-related outbreak signatures.	2007 Oct 5	17919318
A laparoscopic simulator tool for objective measurement of residents' laparoscopic ability.	2007 Oct-Dec	18237513
Effects of interpregnancy interval and outcome of the preceding pregnancy on pregnancy outcomes in Matlab, Bangladesh.	2007 Sep	17617195
Double blind, randomized, placebo controlled clinical trial for the treatment of diabetic foot ulcers, using a nitric oxide releasing patch: PATHON.	2007 Sep 26	17897470
The organizational effects of oxytocin on the central expression of estrogen receptor alpha and oxytocin in adulthood.	2007 Sep 7	17825097
Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration.	2008	18625036
Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole.	2008	18615197
The Cuyahoga is still burning.	2008 Apr	18414602
Strain-specific virulence phenotypes of Streptococcus pneumoniae assessed using the Chinchilla laniger model of otitis media.	2008 Apr 9	18398481
Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.	2008 Aug 22	18725925
Effects of the selective serotonin reuptake inhibitor fluoxetine on counterregulatory responses to hypoglycemia in individuals with type 1 diabetes.	2008 Dec	18835927
Antibiotics and antiseptics for venous leg ulcers.	2008 Jan 23	18254024
The Akron dome midfoot osteotomy as a salvage procedure for the treatment of rigid pes cavus: a retrospective review.	2008 Jan-Feb	18157049
Mixtures of quaternary ammonium compounds and anionic organic compounds in the aquatic environment: Elimination and biodegradability in the closed bottle test monitored by LC-MS/MS.	2008 Jun	18439651
A 12 week, open label, phase I/IIa study using apatone for the treatment of prostate cancer patients who have failed standard therapy.	2008 Mar 24	18392145
Testosterone influences renal electrolyte excretion in SHR/y and WKY males.	2008 Mar 26	18366771
Misoprostol preferable to ethacridine lactate for abortions at 13-20 weeks of pregnancy: Cuban experience.	2008 May	18772100
Second trimester abortions in India.	2008 May	18772082
Brisk walking compared with an individualised medical fitness programme for patients with type 2 diabetes: a randomised controlled trial.	2008 May	18297259
Sticky gecko feet: the role of temperature and humidity.	2008 May 14	18478106
Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensing.	2008 Oct	18519802
Effects of a selective serotonin reuptake inhibitor, fluoxetine, on counterregulatory responses to hypoglycemia in healthy individuals.	2008 Sep	18567822
Genomics, molecular imaging, bioinformatics, and bio-nano-info integration are synergistic components of translational medicine and personalized healthcare research.	2008 Sep 16	18831773
The design, development, and evaluation of a prototypic, prosthetic venous valve.	2008 Sep 19	18803829
Hemodialysis vascular access options in pediatrics: considerations for patients and practitioners.	2009 Jun	18392860

Patents

Sample Use Guides

In Vivo Use Guide

Apply 0,1 % cutaneous solution to the affected area of skin.

Route of Administration: Topical

In Vitro Use Guide

Ethacridine shows weak becteriostatic activity against gram-positive bacteria with MIC 1-10 ug/ml.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:12:01 GMT 2023` Edited by `admin` on `Fri Dec 15 15:12:01 GMT 2023`
Record UNII	V5IL571C1T
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ETHACRIDINE LACTATE

Common Name

English

Ethacridine lactate monohydrate [WHO-DD]

Common Name

English

VUCINE

Brand Name

English

METIFEX

Brand Name

English

6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE MONOHYDRATE

Systematic Name

English

ACRINOL HYDRATE [JAN]

Common Name

English

RIVANOL

Brand Name

English

ETHACRIDINE LACTATE MONOHYDRATE [EP MONOGRAPH]

Common Name

English

ETHODIN

Brand Name

English

ETHACRIDINE LACTATE [MART.]

Common Name

English

ETHACRIDINE LACTATE MONOHYDRATE [EP IMPURITY]

Common Name

English

PROPANOIC ACID, 2-HYDROXY-, COMPD. WITH 7-ETHOXY-3,9-ACRIDINEDIAMINE, HYDRATE (1:1:1)

Common Name

English

ETHACRIDINE LACTATE MONOHYDRATE [MI]

Common Name

English

ACRINOL HYDRATE

Common Name

English

RIMAON

Brand Name

English

ACROLACTIN

Brand Name

English

ANTIDIAR 200

Brand Name

English

Classification Tree Code System Code

WHO-ATC

D08AA01