SYMETINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C30H48N2O2
Molecular Weight	468.7143
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCN(C)CC1=CC=C(OCCOC2=CC=C(CN(C)CCCCCC)C=C2)C=C1

InChI

InChIKey=XVGLWUPIJXJSOB-UHFFFAOYSA-N

InChI=1S/C30H48N2O2/c1-5-7-9-11-21-31(3)25-27-13-17-29(18-14-27)33-23-24-34-30-19-15-28(16-20-30)26-32(4)22-12-10-8-6-2/h13-20H,5-12,21-26H2,1-4H3

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15445946 | https://www.ncbi.nlm.nih.gov/pubmed/24543175 | Antibiotics and Chemotherapy (Washington, D. C.) (1954), 4, 753-62.

Symetine is a benzylamine derivative patented by Eli Lilly & Co. as an antiparasitic and antispirochete agent. In preclinical models, Symetine effectively suppresses amebic liver abscess in guinea pigs.

Originator

Approval Year

PubMed

Title	Date	PubMed
Symetine hydrochloride in the treatment of amebic liver abscess in guinea pigs.	1963 Mar	15445946

Patents

Name

Type

Language

SYMETINE

Official Name

English

L-16726

Code

English

4,4'-(ETHYLENEDIOXY)BIS(N-HEXYL-N-METHYLBENZYLAMINE)

Systematic Name

English

BENZENEMETHANAMINE, 4,4'-(1,2-ETHANEDIYLBIS(OXY)BIS(N-HEXYL-N-METHYL-

Common Name

English

symetine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C277