SYMETINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C30H48N2O2.2ClH
Molecular Weight	541.636
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.CCCCCCN(C)CC1=CC=C(OCCOC2=CC=C(CN(C)CCCCCC)C=C2)C=C1

InChI

InChIKey=AVQAMDIAGIHYPS-UHFFFAOYSA-N

InChI=1S/C30H48N2O2.2ClH/c1-5-7-9-11-21-31(3)25-27-13-17-29(18-14-27)33-23-24-34-30-19-15-28(16-20-30)26-32(4)22-12-10-8-6-2;;/h13-20H,5-12,21-26H2,1-4H3;2*1H

HIDE SMILES / InChI

Molecular Formula	C30H48N2O2
Molecular Weight	468.7143
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15445946 | https://www.ncbi.nlm.nih.gov/pubmed/24543175 | Antibiotics and Chemotherapy (Washington, D. C.) (1954), 4, 753-62.

Symetine is a benzylamine derivative patented by Eli Lilly & Co. as an antiparasitic and antispirochete agent. In preclinical models, Symetine effectively suppresses amebic liver abscess in guinea pigs.

Originator

Approval Year

PubMed

Title	Date	PubMed
Symetine hydrochloride in the treatment of amebic liver abscess in guinea pigs.	1963 Mar	15445946

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:28:27 GMT 2023` Edited by `admin` on `Fri Dec 15 16:28:27 GMT 2023`
Record UNII	S175C652YS
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SYMETINE HYDROCHLORIDE

Official Name

English

BENZENEMETHANAMINE, 4,4'-(1,2-ETHANEDIYLBIS(OXY))BIS(N-HEXYL-N-METHYL-, DIHYDROCHLORIDE

Common Name

English

SYMETINE HCL

Common Name

English

SYMETINE HYDROCHLORIDE [USAN]

Common Name

English

BENZENEMETHANAMINE, 4,4'-(1,2-ETHANEDIYLBIS(OXY))BIS(N-HEXYL-N-METHYL-, HYDROCHLORIDE (1:2)

Systematic Name

English

4,4'-(ETHYLENEDIOXY)BIS(N-HEXYL-N-METHYLBENZYLAMINE) DIHYDROCHLORIDE

Systematic Name

English

NSC-81908

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C737