U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C18H21NO3
Molecular Weight 299.3642
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CODEINE ANHYDROUS

SMILES

[H][C@@]12OC3=C4C(C[C@H]5N(C)CC[C@@]14[C@@]5([H])C=C[C@@H]2O)=CC=C3OC

InChI

InChIKey=OROGSEYTTFOCAN-DNJOTXNNSA-N
InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1

HIDE SMILES / InChI
Codeine is an opiate used to manage mild to moderate pain severe enough to require an opioid. Codeine is a selective agonist for the mu opioid receptor and has an affinity to delta and kappa-opioid receptors. In some countries, this drug is regulated under various narcotic control laws, because its chronic use can cause physical dependence. In others, it is available without a medical prescription in combination with paracetamol.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
6.1 µM [EC50]
Target ID: P41145
Gene ID: 4986.0
Gene Symbol: OPRK1
Target Organism: Homo sapiens (Human)
Target ID: P41143
Gene ID: 4985.0
Gene Symbol: OPRD1
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
CAPITAL AND CODEINE

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Analgesic abuse, ureteric obstruction, and retroperitoneal fibrosis.
1975 Apr 12
Over-the-counter medications for acute cough in children and adults in ambulatory settings.
2001
Dystonia as acute adverse reaction to cough suppressant in a 3-year-old girl.
2001
[Guillain-Barre syndrome as a result of poisoning with a mixture of "kompot"(Polish heroin) and drugs].
2001
Saliva testing after single and chronic administration of dihydrocodeine.
2001
The use of compound 48/80 and codeine phosphate as positive controls for intradermal skin testing in dogs.
2001 Apr
Chromatographic analysis of phenethylamine-antihistamine combinations using C8, C18 or cyano columns and micellar sodium dodecyl sulfate-pentanol mixtures.
2001 Apr
Angle closure risk from proprietary medicines.
2001 Apr
The diagnosis and treatment of cough.
2001 Apr 5
Simultaneous determination of codeine and ethyl morphine HCL in tablet formulations using LC.
2001 Aug
Precipitated withdrawal following codeine administration is dependent on CYP genotype.
2001 Aug 17
[Paracetamol-codeine induced hepatic colic].
2001 Aug-Sep
LC method for the analysis of paracetamol, caffeine and codeine phosphate in pharmaceutical preparations.
2001 Dec
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
2001 Feb
Effect of prophylactic amoxicillin on endodontic flare-up in asymptomatic, necrotic teeth.
2001 Jan
Opiate-sensitivity: clinical characteristics and the role of skin prick testing.
2001 Jul
Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review.
2001 Jul 7
Heroin use by motorists in Sweden confirmed by analysis of 6-acetylmorphine in urine.
2001 Jul-Aug
Laboratory analysis of remotely collected oral fluid specimens for opiates by immunoassay.
2001 Jul-Aug
[Chronic pain in geriatrics].
2001 Jun
Ulcerated hemangiomas: clinical characteristics and response to therapy.
2001 Jun
Time of drug elimination in chronic drug abusers. Case study of 52 patients in a "low-step" detoxification ward.
2001 Jun 15
[Information on preparations containing codeine].
2001 Jun 20
Codeine phosphate in paediatric medicine.
2001 Mar
Codeine phosphate in children: time for re-evaluation?
2001 Mar
Myocardial Infarction associated with methadone and/or dihydrocodeine.
2001 Mar
GC-MS determination of heroin metabolites in meconium: evaluation of four solid-phase extraction cartridges.
2001 Mar
Quantitation of morphine and codeine in human urine using high-filed asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection.
2001 Mar
Acetylcodeine as a marker of illicit heroin in human hair: method validation and results of a pilot study.
2001 Mar
The analgesic effect of codeine as compared to imipramine in different human experimental pain models.
2001 May
[Analgesics-induced chronic renal failure in patients on dialysis therapy in Hungary].
2001 May 13
Regional block and mexiletine: the effect on pain after cancer breast surgery.
2001 May-Jun
Scalp nerve blocks decrease the severity of pain after craniotomy.
2001 Nov
Concentration ratios of morphine to codeine in blood of impaired drivers as evidence of heroin use and not medication with codeine.
2001 Nov
Nutritional effects of surgical and medical treatment for short bowel syndrome.
2001 Nov-Dec
Novel dynamic polymer coating for capillary electrophoresis in nonaqueous methanolic background electrolytes.
2001 Oct
Seizures with intravenous codeine phosphate.
2001 Oct
Ropivacaine with or without clonidine improves pediatric tonsillectomy pain.
2001 Oct
Drug contamination of US paper currency.
2001 Oct 1
Predictors for completing an inpatient detoxification program among intravenous heroin users, methadone substituted and codeine substituted patients.
2001 Oct 1
Spontaneous reports on drug-induced pancreatitis in Denmark from 1968 to 1999.
2001 Sep
Community pharmacists' experience of over-the-counter medicine misuse in Scotland.
2001 Sep
Blind trials of an onsite saliva drug test for marijuana and opiates.
2001 Sep
[Weak opioids].
2001 Sep
[Strong opioids].
2001 Sep
Concentration ratios of codeine-to-morphine in plasma after a single oral dose (100 mg) of codeine phosphate.
2001 Sep
Detection of non-prescription heroin markers in urine with liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
2001 Sep
Engineering novel biocatalytic routes for production of semisynthetic opiate drugs.
2001 Sep
Can standard open pediatric urological procedures be performed on an outpatient basis?
2001 Sep
Experience with urine drug testing by the Correctional Service of Canada.
2001 Sep 15
Patents

Sample Use Guides

Unknown
Route of Administration: Oral
Name Type Language
CODEINE ANHYDROUS
Common Name English
MYTUSSIN
Common Name English
ETHYLMORPHINE HYDROCHLORIDE IMPURITY C [EP IMPURITY]
Common Name English
IDS-NC-005(SECT.-2)
Code English
CODEINE [HSDB]
Common Name English
CODEINE [MI]
Common Name English
SS85U8K5ZN
Common Name English
KODELAK FITO
Common Name English
MORPHINE MONOMETHYL ETHER
Common Name English
HYDROCODONE HYDROGEN TARTRATE 2.5-HYDRATE IMPURITY C [EP IMPURITY]
Common Name English
7,8-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol
Systematic Name English
O3-METHYLMORPHINE
Common Name English
CODICEPT
Common Name English
DIHYDROCODEINE HYDROGEN TARTRATE IMPURITY A [EP IMPURITY]
Common Name English
Codeine [WHO-DD]
Common Name English
METHYLMORPHINE
Common Name English
CODUCEPT
Common Name English
MORPHINAN-6-OL, 7,8-DIDEHYDRO-4,5-EPOXY-3-METHOXY-17-METHYL-, (5.ALPHA.,6.ALPHA.)-
Systematic Name English
MORPHINE SULFATE IMPURITY A [EP IMPURITY]
Common Name English
MORPHINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]
Common Name English
Classification Tree Code System Code
NDF-RT N0000175690
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
NDF-RT N0000175684
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
CFR 21 CFR 862.3270
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
DEA NO. 9050
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
WHO-ATC N02AJ09
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
Code System Code Type Description
DRUG BANK
DB00318
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
SMS_ID
100000079790
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
CAS
76-57-3
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
NCI_THESAURUS
C171855
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
ALTERNATIVE
ECHA (EC/EINECS)
200-969-1
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
PUBCHEM
5284371
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
MERCK INDEX
m3718
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C77284
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
CHEBI
16714
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
EPA CompTox
DTXSID2020341
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
DAILYMED
UX6OWY2V7J
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
RXCUI
236131
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
ALTERNATIVE
RXCUI
1545976
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
HSDB
3043
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
EVMPD
SUB127261
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
EVMPD
SUB13424MIG
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY
FDA UNII
UX6OWY2V7J
Created by admin on Fri Dec 15 16:30:16 UTC 2023 , Edited by admin on Fri Dec 15 16:30:16 UTC 2023
PRIMARY