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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H21NO3.H3O4P
Molecular Weight 397.3594
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CODEINE PHOSPHATE ANHYDROUS

SMILES

OP(O)(O)=O.[H][C@@]12OC3=C4C(C[C@H]5N(C)CC[C@@]14[C@@]5([H])C=C[C@@H]2O)=CC=C3OC

InChI

InChIKey=WUXLCJZUUHIXFY-FFHNEAJVSA-N
InChI=1S/C18H21NO3.H3O4P/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-5(2,3)4/h3-6,11-13,17,20H,7-9H2,1-2H3;(H3,1,2,3,4)/t11-,12+,13-,17-,18-;/m0./s1

HIDE SMILES / InChI

Molecular Formula C18H21NO3
Molecular Weight 299.3642
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula H3O4P
Molecular Weight 97.9952
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Codeine is an opiate used to manage mild to moderate pain severe enough to require an opioid. Codeine is a selective agonist for the mu opioid receptor and has an affinity to delta and kappa-opioid receptors. In some countries, this drug is regulated under various narcotic control laws, because its chronic use can cause physical dependence. In others, it is available without a medical prescription in combination with paracetamol.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
6.1 µM [EC50]
Target ID: P41145
Gene ID: 4986.0
Gene Symbol: OPRK1
Target Organism: Homo sapiens (Human)
Target ID: P41143
Gene ID: 4985.0
Gene Symbol: OPRD1
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
CAPITAL AND CODEINE

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Analgesic abuse, ureteric obstruction, and retroperitoneal fibrosis.
1975 Apr 12
Over-the-counter medications for acute cough in children and adults in ambulatory settings.
2001
Determination of opiates in serum, saliva and hair addicted persons.
2001
Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis.
2001
Saliva testing after single and chronic administration of dihydrocodeine.
2001
The use of compound 48/80 and codeine phosphate as positive controls for intradermal skin testing in dogs.
2001 Apr
[Adverse cutaneous side-effect of codeine administration].
2001 Apr 15
The diagnosis and treatment of cough.
2001 Apr 5
Sticky business: patterns of procurement and misuse of prescription cough syrup in Houston.
2001 Apr-Jun
Prescribing limitations.
2001 Aug 11
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
2001 Feb
Effect of prophylactic amoxicillin on endodontic flare-up in asymptomatic, necrotic teeth.
2001 Jan
Dose-related effects of controlled release dihydrocodeine on oro-cecal transit and pupillary light reflex. A study in human volunteers.
2001 Jan
Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg.
2001 Jan 10
Heroin use by motorists in Sweden confirmed by analysis of 6-acetylmorphine in urine.
2001 Jul-Aug
[Chronic pain in geriatrics].
2001 Jun
Successful withdrawal from analgesic abuse in a group of youngsters with chronic daily headache.
2001 Jun
Myth: codeine is a powerful and effective analgesic.
2001 Jun
Analysis of cocaine, benzoylecgonine, codeine, and morphine in hair by supercritical fluid extraction with carbon dioxide modified with methanol.
2001 Jun 1
Time of drug elimination in chronic drug abusers. Case study of 52 patients in a "low-step" detoxification ward.
2001 Jun 15
[Information on preparations containing codeine].
2001 Jun 20
Codeine phosphate in paediatric medicine.
2001 Mar
Codeine phosphate in children: time for re-evaluation?
2001 Mar
Expression and activity of cell-wall-degrading enzymes in the latex of opium poppy, Papaver somniferum L.
2001 Mar
Myocardial Infarction associated with methadone and/or dihydrocodeine.
2001 Mar
GC-MS determination of heroin metabolites in meconium: evaluation of four solid-phase extraction cartridges.
2001 Mar
Quantitation of morphine and codeine in human urine using high-filed asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection.
2001 Mar
Acetylcodeine as a marker of illicit heroin in human hair: method validation and results of a pilot study.
2001 Mar
Treatment of severe pain from osteoarthritis with slow-release tramadol or dihydrocodeine in combination with NSAID's: a randomised study comparing analgesia, antinociception and gastrointestinal effects.
2001 Mar
Evaluation of urinary dihydrocodeine excretion in human by gas chromatography-mass spectrometry.
2001 Mar 5
Dihydrocodeine--drug of use or misuse?
2001 May
Capillary electrophoresis-electrospray ionization ion trap mass spectrometry for analysis and confirmation testing of morphine and related compounds in urine.
2001 May 4
Application of liquid chromatography to the simultaneous determination of acetylsalicylic acid, caffeine, codeine, paracetamol, pyridoxine, and thiamine in pharmaceutical preparations.
2001 May-Jun
Scalp nerve blocks decrease the severity of pain after craniotomy.
2001 Nov
Concentration ratios of morphine to codeine in blood of impaired drivers as evidence of heroin use and not medication with codeine.
2001 Nov
The role of adrenal corticosteroids in induction of micronuclei by morphine.
2001 Nov 15
Ropivacaine with or without clonidine improves pediatric tonsillectomy pain.
2001 Oct
Drug contamination of US paper currency.
2001 Oct 1
Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial.
2001 Sep
Blind trials of an onsite saliva drug test for marijuana and opiates.
2001 Sep
[Weak opioids].
2001 Sep
[Strong opioids].
2001 Sep
Concentration ratios of codeine-to-morphine in plasma after a single oral dose (100 mg) of codeine phosphate.
2001 Sep
Detection of non-prescription heroin markers in urine with liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
2001 Sep
Patents

Sample Use Guides

Unknown
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:39:30 GMT 2023
Edited
by admin
on Fri Dec 15 17:39:30 GMT 2023
Record UNII
2X585M1M3T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CODEINE PHOSPHATE ANHYDROUS
Common Name English
Codeine phosphate [WHO-DD]
Common Name English
MORPHINAN-6-OL, 7,8-DIDEHYDRO-4,5-EPOXY-3-METHOXY-17-METHYL-, (5.ALPHA.,6.ALPHA.)-, PHOSPHATE (1:1) (SALT)
Common Name English
CODEINE PHOSPHATE [MI]
Common Name English
7,8-DIDEHYDRO-4,5.ALPHA.-EPOXY-3-METHOXY-17-METHYLMORPHINAN-6.ALPHA.-OL PHOSPHATE (1:1) (SALT)
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID0024844
Created by admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
PRIMARY
CAS
52-28-8
Created by admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
PRIMARY
DAILYMED
2X585M1M3T
Created by admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
PRIMARY
PUBCHEM
5359227
Created by admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
PRIMARY
MERCK INDEX
m3718
Created by admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
PRIMARY Merck Index
RXCUI
1652891
Created by admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
PRIMARY RxNorm
SMS_ID
100000079791
Created by admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
PRIMARY
FDA UNII
2X585M1M3T
Created by admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-137-8
Created by admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS
Related Record Type Details
ACTIVE MOIETY