Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | 2C18H21NO3.H2O4S |
| Molecular Weight | 696.807 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OS(O)(=O)=O.[H][C@@]12OC3=C4C(C[C@H]5N(C)CC[C@@]14[C@@]5([H])C=C[C@@H]2O)=CC=C3OC.[H][C@@]67OC8=C9C(C[C@H]%10N(C)CC[C@@]69[C@@]%10([H])C=C[C@@H]7O)=CC=C8OC
InChI
InChIKey=BCXHDORHMMZBBZ-DORFAMGDSA-N
InChI=1S/2C18H21NO3.H2O4S/c2*1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-5(2,3)4/h2*3-6,11-13,17,20H,7-9H2,1-2H3;(H2,1,2,3,4)/t2*11-,12+,13-,17-,18-;/m00./s1
| Molecular Formula | H2O4S |
| Molecular Weight | 98.078 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C18H21NO3 |
| Molecular Weight | 299.3642 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Codeine is an opiate used to manage mild to moderate pain severe enough to require an opioid. Codeine is a selective agonist for the mu opioid receptor and has an affinity to delta and kappa-opioid receptors. In some countries, this drug is regulated under various narcotic control laws, because its chronic use can cause physical dependence. In others, it is available without a medical prescription in combination with paracetamol.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL233 |
6.1 µM [EC50] | ||
Target ID: P41145 Gene ID: 4986.0 Gene Symbol: OPRK1 Target Organism: Homo sapiens (Human) |
|||
Target ID: P41143 Gene ID: 4985.0 Gene Symbol: OPRD1 Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | CAPITAL AND CODEINE Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Over-the-counter medications for acute cough in children and adults in ambulatory settings. | 2001 |
|
| Dystonia as acute adverse reaction to cough suppressant in a 3-year-old girl. | 2001 |
|
| [Pharmacokinetic and toxicokinetic parameters of some drugs of abuse]. | 2001 |
|
| [Guillain-Barre syndrome as a result of poisoning with a mixture of "kompot"(Polish heroin) and drugs]. | 2001 |
|
| Sticky business: patterns of procurement and misuse of prescription cough syrup in Houston. | 2001 Apr-Jun |
|
| Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women. | 2001 Aug |
|
| Simultaneous determination of codeine and ethyl morphine HCL in tablet formulations using LC. | 2001 Aug |
|
| Precipitated withdrawal following codeine administration is dependent on CYP genotype. | 2001 Aug 17 |
|
| [Paracetamol-codeine induced hepatic colic]. | 2001 Aug-Sep |
|
| LC method for the analysis of paracetamol, caffeine and codeine phosphate in pharmaceutical preparations. | 2001 Dec |
|
| Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth. | 2001 Feb |
|
| Opiate-sensitivity: clinical characteristics and the role of skin prick testing. | 2001 Jul |
|
| Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis. | 2001 Jul |
|
| Head-column field-amplified sample stacking in presence of siphoning. Application to capillary electrophoresis-electrospray ionization mass spectrometry of opioids in urine. | 2001 Jul 27 |
|
| Use of beta-cyclodextrin in the capillary zone electrophoretic separation of the components of clandestine heroin preparations. | 2001 Jul 27 |
|
| Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. | 2001 Jul 7 |
|
| Heroin use by motorists in Sweden confirmed by analysis of 6-acetylmorphine in urine. | 2001 Jul-Aug |
|
| Successful withdrawal from analgesic abuse in a group of youngsters with chronic daily headache. | 2001 Jun |
|
| Analysis of cocaine, benzoylecgonine, codeine, and morphine in hair by supercritical fluid extraction with carbon dioxide modified with methanol. | 2001 Jun 1 |
|
| [Information on preparations containing codeine]. | 2001 Jun 20 |
|
| Codeine phosphate in paediatric medicine. | 2001 Mar |
|
| Codeine phosphate in children: time for re-evaluation? | 2001 Mar |
|
| Expression and activity of cell-wall-degrading enzymes in the latex of opium poppy, Papaver somniferum L. | 2001 Mar |
|
| Dextromethorphan is an effective cough suppressant. | 2001 May |
|
| [Analgesics-induced chronic renal failure in patients on dialysis therapy in Hungary]. | 2001 May 13 |
|
| From codeine to transdermal fentanyl for cancer pain control: a safety and efficacy clinical trial. | 2001 May-Jun |
|
| Application of liquid chromatography to the simultaneous determination of acetylsalicylic acid, caffeine, codeine, paracetamol, pyridoxine, and thiamine in pharmaceutical preparations. | 2001 May-Jun |
|
| Scalp nerve blocks decrease the severity of pain after craniotomy. | 2001 Nov |
|
| The role of adrenal corticosteroids in induction of micronuclei by morphine. | 2001 Nov 15 |
|
| Nutritional effects of surgical and medical treatment for short bowel syndrome. | 2001 Nov-Dec |
|
| Novel dynamic polymer coating for capillary electrophoresis in nonaqueous methanolic background electrolytes. | 2001 Oct |
|
| Analysis of morphine and codeine in samples adulterated with Stealth. | 2001 Oct |
|
| Detection of opiate use in a methadone maintenance treatment population with the CEDIA 6-acetylmorphine and CEDIA DAU opiate assays. | 2001 Oct |
|
| Ropivacaine with or without clonidine improves pediatric tonsillectomy pain. | 2001 Oct |
|
| Drug contamination of US paper currency. | 2001 Oct 1 |
|
| Predictors for completing an inpatient detoxification program among intravenous heroin users, methadone substituted and codeine substituted patients. | 2001 Oct 1 |
|
| Endogenous morphine and codeine. Possible role as endogenous anticonvulsants. | 2001 Oct 12 |
|
| Spontaneous reports on drug-induced pancreatitis in Denmark from 1968 to 1999. | 2001 Sep |
|
| Community pharmacists' experience of over-the-counter medicine misuse in Scotland. | 2001 Sep |
|
| Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study. | 2001 Sep |
|
| Rofecoxib versus codeine/acetaminophen in postoperative dental pain: a double-blind, randomized, placebo- and active comparator-controlled clinical trial. | 2001 Sep |
|
| Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial. | 2001 Sep |
|
| Blind trials of an onsite saliva drug test for marijuana and opiates. | 2001 Sep |
|
| [Weak opioids]. | 2001 Sep |
|
| [Strong opioids]. | 2001 Sep |
|
| Concentration ratios of codeine-to-morphine in plasma after a single oral dose (100 mg) of codeine phosphate. | 2001 Sep |
|
| Detection of non-prescription heroin markers in urine with liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. | 2001 Sep |
|
| Pain control in medical abortion. | 2001 Sep |
|
| Engineering novel biocatalytic routes for production of semisynthetic opiate drugs. | 2001 Sep |
|
| Experience with urine drug testing by the Correctional Service of Canada. | 2001 Sep 15 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:00:59 UTC 2023
by
admin
on
Sat Dec 16 01:00:59 UTC 2023
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| Record UNII |
AVW5HY4N2E
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID80161921
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DBSALT000031
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AVW5HY4N2E
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215-818-5
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1420-53-7
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m3718
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5359613
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE | |||
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SOLVATE->ANHYDROUS |
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |