BEVONIUM METILSULFATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H28NO3.CH3O4S
Molecular Weight	465.56
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COS([O-])(=O)=O.C[N+]1(C)CCCCC1COC(=O)C(O)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=AXKJGGRSAVLXTE-UHFFFAOYSA-M

InChI=1S/C22H28NO3.CH4O4S/c1-23(2)16-10-9-15-20(23)17-26-21(24)22(25,18-11-5-3-6-12-18)19-13-7-4-8-14-19;1-5-6(2,3)4/h3-8,11-14,20,25H,9-10,15-17H2,1-2H3;1H3,(H,2,3,4)/q+1;/p-1

HIDE SMILES / InChI

Description
Sources: http://infomeds.net/akabel.html | http://www.genome.jp/dbget-bin/www_bget?dr:D01532

Bevonium is a parasympatolytic antimuscarinic compound. It possesses spasmolytic properties. The use of the drug is discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 160 Target ID: CHEMBL2094109 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D01532	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Spasm 18 Sources: http://infomeds.net/akabel.html	Primary		Approved 8429	ACABEL Approved Use Acabel (Bevonium methyl sulfate) is parasympatolytic drug with well balanced action on the neuromuscular device. Possesses broncho-and spasmolytic properties. Acabel is indicated for bronchial asthma, peptic ulcer of a stomach and duodenum, pylorospasm, postoperative spastic pains, spastic locks, cholestasia, cholecystitis, cholangitis, postcholecystectomy syndrome, chronic hepatopathy and pancreatitis, various diseases of kidneys and urinary tract. Prenatal and puerperal pains, dysmenorrhea, adnexitis, endometritis, dysfunction of ovaries, tumor of genitalias.

PubMed

Title	Date	PubMed
[Bevonium methylsulfate (CG 201) in the treatment of enuresis and bladder neurosis].	1970 Jul	5465265

Patents

Sample Use Guides

In Vivo Use Guide

Form of release of medicine: Acabel: tablets on 50 mg, candles on 30 pieces in packaging. Acabel compositum: tablets (bevonium methyl sulfate — 0,05 g, Dipyronum — 0,25 g); candles (bevonium methyl sulfate — 0,03 g, Dipyronum — 1 g); ampoules on 5 ml (bevonium methyl sulfate — 0,0025 g, Dipyronum — 2,5 g). Use: Acabel appoint inside 1 — 2 tablet 2 — 3 times a day, candles (only the adult) — on 1 piece 2 — 3 times a day. Intramusculary or intravenously slowly enter on 1/2 — 1 ampoule of an akabel difficult 3 once a day.

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

BEVONIUM METILSULFATE

Official Name

English

2-(HYDROXYMETHYL)-1,1-DIMETHYLPIPERIDINIUM METHYLSULFATE, BENZILATE

Systematic Name

English

BEVONIUM METILSULFATE [MART.]

Common Name

English

BEVONIUM METHYLSULFATE [JAN]

Common Name

English

bevonium metilsulfate [INN]

Common Name

English

PIPERIDINIUM, 2-(((2-HYDROXY-2,2-DIPHENYLACETYL)OXY)METHYL)-1,1-DIMETHYL-, METHYL SULFATE (1:1)

Common Name

English

ACABEL

Brand Name

English

CG-201

Code

English

BEVONIUM METHYL SULFATE [MI]

Common Name

English

Bevonium metilsulfate [WHO-DD]

Common Name

English

CG 201

Code

English

BEVONIUM METILSULPHATE

Common Name

English

PIRIBENZIL METHYLSULFATE

Common Name

English

BEVONIUM METHYLSULFATE

Common Name

English

BEVONIUM METHYLSULPHATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66880