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Details

Stereochemistry RACEMIC
Molecular Formula C22H28NO3.CH3O4S
Molecular Weight 465.56
Optical Activity ( + / - )
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BEVONIUM METILSULFATE

SMILES

COS([O-])(=O)=O.C[N+]1(C)CCCCC1COC(=O)C(O)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=AXKJGGRSAVLXTE-UHFFFAOYSA-M
InChI=1S/C22H28NO3.CH4O4S/c1-23(2)16-10-9-15-20(23)17-26-21(24)22(25,18-11-5-3-6-12-18)19-13-7-4-8-14-19;1-5-6(2,3)4/h3-8,11-14,20,25H,9-10,15-17H2,1-2H3;1H3,(H,2,3,4)/q+1;/p-1

HIDE SMILES / InChI
Molecular Formula CH3O4S
Molecular Weight 111.097
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C22H28NO3
Molecular Weight 354.4626
Charge 1
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity ( + / - )

Description

Bevonium is a parasympatolytic antimuscarinic compound. It possesses spasmolytic properties. The use of the drug is discontinued.

Originator

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2849
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
ACABEL

Approved Use

Acabel (Bevonium methyl sulfate) is parasympatolytic drug with well balanced action on the neuromuscular device. Possesses broncho-and spasmolytic properties. Acabel is indicated for bronchial asthma, peptic ulcer of a stomach and duodenum, pylorospasm, postoperative spastic pains, spastic locks, cholestasia, cholecystitis, cholangitis, postcholecystectomy syndrome, chronic hepatopathy and pancreatitis, various diseases of kidneys and urinary tract. Prenatal and puerperal pains, dysmenorrhea, adnexitis, endometritis, dysfunction of ovaries, tumor of genitalias.
Doses

Doses

DosePopulationAdverse events​
300 mg 3 times / day multiple, oral
Highest studied dose
Dose: 300 mg, 3 times / day
Route: oral
Route: multiple
Dose: 300 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/5750161/
unhealthy, ADULT
Health Status: unhealthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/5750161/
Sources:
https://pubmed.ncbi.nlm.nih.gov/5750161/
5 mg single, intramuscular
Highest studied dose
Dose: 5 mg
Route: intramuscular
Route: single
Dose: 5 mg
Sources:
https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/119934
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/119934
Sources:
https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/119934
PubMed

PubMed

TitleDatePubMed
Letter: A double-blind trial of bevonium methylsulphate on gastric acid secretion in man.
1976-01-03
[Bevonium methylsulfate (CG 201) in the treatment of enuresis and bladder neurosis].
1970-07
[Effect of piribenzil methylsulfate (CG-201) on ureteral activity].
1968-11
Patents

Patents

20050261242
4
BE616951
2

Sample Use Guides

In Vivo Use Guide
Form of release of medicine: Acabel: tablets on 50 mg, candles on 30 pieces in packaging. Acabel compositum: tablets (bevonium methyl sulfate — 0,05 g, Dipyronum — 0,25 g); candles (bevonium methyl sulfate — 0,03 g, Dipyronum — 1 g); ampoules on 5 ml (bevonium methyl sulfate — 0,0025 g, Dipyronum — 2,5 g). Use: Acabel appoint inside 1 — 2 tablet 2 — 3 times a day, candles (only the adult) — on 1 piece 2 — 3 times a day. Intramusculary or intravenously slowly enter on 1/2 — 1 ampoule of an akabel difficult 3 once a day.
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:02:56 GMT 2025
Edited
by admin
on Mon Mar 31 18:02:56 GMT 2025
Record UNII
UWC15E373Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BEVONIUM METILSULFATE
INN   MART.   WHO-DD  
INN  
Official Name English
BEVONIUM METHYLSULFATE
JAN  
Preferred Name English
2-(HYDROXYMETHYL)-1,1-DIMETHYLPIPERIDINIUM METHYLSULFATE, BENZILATE
Systematic Name English
BEVONIUM METILSULFATE [MART.]
Common Name English
BEVONIUM METHYLSULFATE [JAN]
Common Name English
bevonium metilsulfate [INN]
Common Name English
PIPERIDINIUM, 2-(((2-HYDROXY-2,2-DIPHENYLACETYL)OXY)METHYL)-1,1-DIMETHYL-, METHYL SULFATE (1:1)
Common Name English
ACABEL
Brand Name English
CG-201
Code English
BEVONIUM METHYL SULFATE [MI]
Common Name English
Bevonium metilsulfate [WHO-DD]
Common Name English
CG 201
Code English
BEVONIUM METILSULPHATE
Common Name English
PIRIBENZIL METHYLSULFATE
Common Name English
BEVONIUM METHYLSULPHATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66880
Created by admin on Mon Mar 31 18:02:56 GMT 2025 , Edited by admin on Mon Mar 31 18:02:56 GMT 2025
Code System Code Type Description
PUBCHEM
31799
Created by admin on Mon Mar 31 18:02:56 GMT 2025 , Edited by admin on Mon Mar 31 18:02:56 GMT 2025
PRIMARY
NCI_THESAURUS
C72944
Created by admin on Mon Mar 31 18:02:56 GMT 2025 , Edited by admin on Mon Mar 31 18:02:56 GMT 2025
PRIMARY
EVMPD
SUB05809MIG
Created by admin on Mon Mar 31 18:02:56 GMT 2025 , Edited by admin on Mon Mar 31 18:02:56 GMT 2025
PRIMARY
ChEMBL
CHEMBL1882461
Created by admin on Mon Mar 31 18:02:56 GMT 2025 , Edited by admin on Mon Mar 31 18:02:56 GMT 2025
PRIMARY
ECHA (EC/EINECS)
226-001-8
Created by admin on Mon Mar 31 18:02:56 GMT 2025 , Edited by admin on Mon Mar 31 18:02:56 GMT 2025
PRIMARY
CAS
5205-82-3
Created by admin on Mon Mar 31 18:02:56 GMT 2025 , Edited by admin on Mon Mar 31 18:02:56 GMT 2025
PRIMARY
EPA CompTox
DTXSID3046615
Created by admin on Mon Mar 31 18:02:56 GMT 2025 , Edited by admin on Mon Mar 31 18:02:56 GMT 2025
PRIMARY
FDA UNII
UWC15E373Z
Created by admin on Mon Mar 31 18:02:56 GMT 2025 , Edited by admin on Mon Mar 31 18:02:56 GMT 2025
PRIMARY
MERCK INDEX
m2467
Created by admin on Mon Mar 31 18:02:56 GMT 2025 , Edited by admin on Mon Mar 31 18:02:56 GMT 2025
PRIMARY Merck Index
SMS_ID
100000085874
Created by admin on Mon Mar 31 18:02:56 GMT 2025 , Edited by admin on Mon Mar 31 18:02:56 GMT 2025
PRIMARY
INN
2456
Created by admin on Mon Mar 31 18:02:56 GMT 2025 , Edited by admin on Mon Mar 31 18:02:56 GMT 2025
PRIMARY
Related Record Type Details
Structure of Methyl sulfate
PARENT -> SALT/SOLVATE
Structure of BEVONIUM METILSULFATE, (R)-
ENANTIOMER -> RACEMATE
Structure of BEVONIUM METILSULFATE, (S)-
ENANTIOMER -> RACEMATE
Structure of BEVONIUM
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of BEVONIUM
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