Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H12N2O8.2Co |
| Molecular Weight | 406.0773 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Co++].[Co++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O
InChI
InChIKey=TWAWHTJKASJPEK-UHFFFAOYSA-J
InChI=1S/C10H16N2O8.2Co/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;2*+2/p-4
DescriptionSources: http://bookshop.europa.eu/en/antidotes-for-poisoning-by-cyanide-pbEUNA14280/downloads/EU-NA-14280-EN-C/EUNA14280ENC_001.pdf;pgid=y8dIS7GUWMdSR0EAlMEUUsWb0000TB7pJDF9?FileName=EUNA14280ENC_001.pdf&SKU=EUNA14280ENC_PDF&CatalogueNumber=EU-NA-14280-EN-C'http://www.edta-chelate.com/cobalt-edta-1640873.html | https://www.ncbi.nlm.nih.gov/pubmed/13641039Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/6787340 | https://www.drugs.com/uk/dicobalt-edetate-injection-300mg-leaflet.html
Sources: http://bookshop.europa.eu/en/antidotes-for-poisoning-by-cyanide-pbEUNA14280/downloads/EU-NA-14280-EN-C/EUNA14280ENC_001.pdf;pgid=y8dIS7GUWMdSR0EAlMEUUsWb0000TB7pJDF9?FileName=EUNA14280ENC_001.pdf&SKU=EUNA14280ENC_PDF&CatalogueNumber=EU-NA-14280-EN-C'http://www.edta-chelate.com/cobalt-edta-1640873.html | https://www.ncbi.nlm.nih.gov/pubmed/13641039
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/6787340 | https://www.drugs.com/uk/dicobalt-edetate-injection-300mg-leaflet.html
Cobalt Disodium Edetate (Cobalt EDTA) is a derivative of Ethylenediamine Tetraacetic Acid. Ethylenediamine Tetraacetic Acid is a Sequestering / Chelating Agent. Cobalt EDTA is a Sequestering Agent, which is normally used in Agriculture and Veterinary application for correcting Cobalt deficiency. Cobalt Disodium Edetate (Cobalt disodium ethylenediamine tetraacetate, Copoietin A) appears to represent the most satisfactory type of
Cobalt-containing hemopoietic agents tested and should be worthy of clinical trial as a therapeutic
agent for the treatment of anemia.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14256807http://www.edta-chelate.com/cobalt-edta-1640873.html
Curator's Comment: The first use of cobalt compounds as cyanide antagonists was advocated by Antal J. in 1894. http://www.firesmoke.org/wp-content/uploads/2010/10/Cyanide_As_A_Weapon.pdf
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P79226 Gene ID: 1.00328928E8 Gene Symbol: ALDOB Target Organism: Oryctolagus cuniculus (Rabbit) |
|||
Target ID: CHEMBL5798 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | SWITCH C Hi Mineral Approved UseRecommended use: Low dose oral drench for the treatment and control of internal
parasites in cattle |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Curative | KELOCYANOR Approved UseDicobalt Edetate Injection is a specific antidote for acute cyanide poisoning. In view of the difficulty of certain diagnosis in emergency situations, it is recommended that Dicobalt Edetate Injection only be given when the patient is tending to lose or has lost consciousness. |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
9.8 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25414476/ |
4.28 mg/kg single, intravenous dose: 4.28 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
COBALT plasma | Sus scrofa population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
518 μg × min/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25414476/ |
4.28 mg/kg single, intravenous dose: 4.28 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
COBALT plasma | Sus scrofa population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
136 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25414476/ |
4.28 mg/kg single, intravenous dose: 4.28 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
COBALT plasma | Sus scrofa population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Also was used orally in rats: Cobalt disodium ethylenediamine tetra-acetate in a
dosage of 4, 8, 10, 20, 40 mg/Kg of elemental cobalt had no
effect on the weight gain of weanling rats.
600 mg (20 ml) in 30 seconds followed by an intravenous injection of 50 ml of hypertonic glucose solution.
Route of Administration:
Intravenous
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NCI_THESAURUS |
C26170
Created by
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C81167
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DICOBALT EDETATE
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253-067-5
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288331
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4989
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71942
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m4835
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SUB13569MIG
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100000079552
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UKC6GH80QR
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DTXSID70189997
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36499-65-7
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PARENT (SALT/SOLVATE)
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
