U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H12N2O8.2Co
Molecular Weight 406.0777
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DICOBALT EDETATE

SMILES

C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Co+2].[Co+2]

InChI

InChIKey=TWAWHTJKASJPEK-UHFFFAOYSA-J
InChI=1S/C10H16N2O8.2Co/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;2*+2/p-4

HIDE SMILES / InChI
Dicobalt edetate was developed as a cyanide antidote based on the known ability of cobalt to form stable complexes with cyanide. One current cobalt-based antidote available in Europe is dicobalt-EDTA, sold as Kelocyanor. This agent chelates cyanide as the cobalticyanide. This drug provides an antidote effect more quickly than formation of methemoglobin. It can be very toxic and cause seizures, upper airway oedema, chest pain, hypotension, vomiting, rashes and dyspnoea especially in those who have not be exposed to cyanide.

Originator

Curator's Comment:: The first use of cobalt compounds as cyanide antagonists was advocated by Antal J. in 1894. http://www.firesmoke.org/wp-content/uploads/2010/10/Cyanide_As_A_Weapon.pdf

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P79226
Gene ID: 1.00328928E8
Gene Symbol: ALDOB
Target Organism: Oryctolagus cuniculus (Rabbit)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
SWITCH C Hi Mineral

Approved Use

Recommended use: Low dose oral drench for the treatment and control of internal parasites in cattle
Primary
Unknown

Approved Use

Unknown
Curative
KELOCYANOR

Approved Use

Dicobalt Edetate Injection is a specific antidote for acute cyanide poisoning. In view of the difficulty of certain diagnosis in emergency situations, it is recommended that Dicobalt Edetate Injection only be given when the patient is tending to lose or has lost consciousness.
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
9.8 μg/mL
4.28 mg/kg single, intravenous
dose: 4.28 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
COBALT plasma
Sus scrofa
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
518 μg × min/mL
4.28 mg/kg single, intravenous
dose: 4.28 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
COBALT plasma
Sus scrofa
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
136 min
4.28 mg/kg single, intravenous
dose: 4.28 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
COBALT plasma
Sus scrofa
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
PubMed

PubMed

TitleDatePubMed
Separation of digesta fractions complicates estimation of ileal digestibility using marker methods with Cr2O3 and cobalt-ethylenediamine tetraacetic acid in broiler chickens.
2014 Aug
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment:: Also was used orally in rats: Cobalt disodium ethylenediamine tetra-acetate in a dosage of 4, 8, 10, 20, 40 mg/Kg of elemental cobalt had no effect on the weight gain of weanling rats.
Rabbits: Rabbits receiving 50 mg/Kg of elemental cobalt intravenously, given as cobalt disodium ethylenediamine tetra-acetate (Cobalt Disodium Edetate), showed no detectable toxic symptoms. Approximately 100 mg/Kg elemental cobalt, administered as rapidly as possible, still produced no toxic symptoms except for a questionable increase in respiratory rate.
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Name Type Language
DICOBALT EDETATE
INN   MART.   WHO-DD  
INN  
Official Name English
DICOBALT ETHYLENEDIAMINETETRAACETATE
Systematic Name English
DICOBALT EDETATE [INN]
Common Name English
COBALT(2+)((ETHYLENEDINITRILO)TETRAACETATO)COBALTATE(2-)
Common Name English
KELOCYANOR
Brand Name English
EDTA COBALT SALT [MI]
Common Name English
DICOBALT EDETATE [MART.]
Common Name English
DICOBALT EDETATE [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C26170
Created by admin on Sat Jun 26 02:49:12 UTC 2021 , Edited by admin on Sat Jun 26 02:49:12 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C81167
Created by admin on Sat Jun 26 02:49:12 UTC 2021 , Edited by admin on Sat Jun 26 02:49:12 UTC 2021
PRIMARY
WIKIPEDIA
DICOBALT EDETATE
Created by admin on Sat Jun 26 02:49:12 UTC 2021 , Edited by admin on Sat Jun 26 02:49:12 UTC 2021
PRIMARY
ECHA (EC/EINECS)
253-067-5
Created by admin on Sat Jun 26 02:49:12 UTC 2021 , Edited by admin on Sat Jun 26 02:49:12 UTC 2021
PRIMARY
RXCUI
288331
Created by admin on Sat Jun 26 02:49:12 UTC 2021 , Edited by admin on Sat Jun 26 02:49:12 UTC 2021
PRIMARY RxNorm
INN
4989
Created by admin on Sat Jun 26 02:49:12 UTC 2021 , Edited by admin on Sat Jun 26 02:49:12 UTC 2021
PRIMARY
PUBCHEM
71942
Created by admin on Sat Jun 26 02:49:12 UTC 2021 , Edited by admin on Sat Jun 26 02:49:12 UTC 2021
PRIMARY
MERCK INDEX
M4835
Created by admin on Sat Jun 26 02:49:12 UTC 2021 , Edited by admin on Sat Jun 26 02:49:12 UTC 2021
PRIMARY Merck Index
EVMPD
SUB13569MIG
Created by admin on Sat Jun 26 02:49:12 UTC 2021 , Edited by admin on Sat Jun 26 02:49:12 UTC 2021
PRIMARY
FDA UNII
UKC6GH80QR
Created by admin on Sat Jun 26 02:49:12 UTC 2021 , Edited by admin on Sat Jun 26 02:49:12 UTC 2021
PRIMARY
EPA CompTox
36499-65-7
Created by admin on Sat Jun 26 02:49:12 UTC 2021 , Edited by admin on Sat Jun 26 02:49:12 UTC 2021
PRIMARY
CAS
36499-65-7
Created by admin on Sat Jun 26 02:49:12 UTC 2021 , Edited by admin on Sat Jun 26 02:49:12 UTC 2021
PRIMARY