U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula 2C6H11O7.Zn
Molecular Weight 455.704
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZINC GLUCONATE

SMILES

[Zn++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

InChI

InChIKey=WHMDKBIGKVEYHS-IYEMJOQQSA-L
InChI=1S/2C6H12O7.Zn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1

HIDE SMILES / InChI
Zinc monocarbonate (Zinc Carbonate) is an inorganic salt. In the United States, Zinc Carbonate may be used as an active ingredient in OTC drug products. When used as an active drug ingredient, the established name is Zinc Carbonate. Zinc monocarbonate is generally recognized as safe by FDA. It is used as skin protectant active ingredient. Zinc carbonate was found to retard the degradation of some poly(lactide-co-glycolide) (PLG) microspheres in vivo and in vitro. Adding Zinc Carbonate is essential during the preparation of PLGA microspheres. It can remarkably improve the stability of drugs in the acid microenvironment inside PLGA microspheres.

CNS Activity

Curator's Comment: Spatial memory deficits in a mouse model of late-onset Alzheimer's disease were caused by Zinc Carbonate supplementation. Long-term dietary administration of zinc ( Zinc Carbonate) can lead to impairments in cognitive function in rats. Microprobe synchrotron X-ray fluorescence (microSXRF) confirmed that brain zinc levels were increased by adding Zinc Carbonate to the drinking water.

Originator

Curator's Comment: Protherics that initially developed Voraxaze was acquired by BTG International in 2008. After the acquisition BTG International completed the development of Voraxaze and submitted the product for US approval.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Primary
CORTROPHIN-ZINC

Approved Use

Treatment of ulcerative colitis and other colonic disorders.

Launch Date

1955
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Secondary
VORAXAZE

Approved Use

Indicated for the treatment of toxic plasma methotrexate concentrations (>1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function. Limitation of use: VORAXAZE is not indicated for use in patients who exhibit the expected clearance of methotrexate (plasma methotrexate concentrations within 2 standard deviations of the mean methotrexate excretion curve specific for the dose of methotrexate administered) or those with normal or mildly impaired renal function because of the potential risk of subtherapeutic exposure to methotrexate.

Launch Date

2012
Primary
VUSION

Approved Use

INDICATIONS AND USAGE VUSION Ointment is indicated for the adjunctive treatment of diaper dermatitis only when complicated by documented candidiasis (microscopic evidence of pseudohyphae and/or budding yeast), in immunocompetent pediatric patients 4 weeks and older. A positive fungal culture for Candida albicans is not adequate evidence of candidal infection since colonization with C. albicans can result in a positive culture. The presence of candidal infection should be established by microscopic evaluation prior to initiating treatment. VUSION Ointment should be used as part of a treatment regimen that includes measures directed at the underlying diaper dermatitis, including gentle cleansing of the diaper area and frequent diaper changes.

Launch Date

2006
Primary
ZINC OXIDE

Approved Use

Unknown
Primary
ZINC SULFATE

Approved Use

Unknown

Launch Date

1987
Primary
ZINC SULFATE

Approved Use

Unknown

Launch Date

1987
Primary
ZINC SULFATE

Approved Use

Unknown

Launch Date

1987
PubMed

PubMed

TitleDatePubMed
A medicated polycarboxylate cement to prevent complications in composite resin therapy.
1990 Jan
Zinc inhibition of renin and the protease from human immunodeficiency virus type 1.
1991 Sep 10
Topical zinc oxide treatment increases endogenous gene expression of insulin-like growth factor-1 in granulation tissue from porcine wounds.
1994 Dec
New applications for the zinc iodide-osmium tetroxide technique.
1994 Feb
Iron chelators as therapeutic agents against Pneumocystis carinii.
1994 May
Cupric ion blocks NF kappa B activation through inhibiting the signal-induced phosphorylation of I kappa B alpha.
1995 Nov 13
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.
1999 May
Inhibition of HIV-1 infection by zinc group metal compounds.
1999 Sep
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.
2002 Mar 1
Thermotoga maritima-Escherichia coli chimeric topoisomerases. Answers about involvement of the carboxyl-terminal domain in DNA topoisomerase I-mediated catalysis.
2004 Jul 16
Inhibition by copper(II) binding of hepatocyte growth factor (HGF) interaction with its receptor Met and blockade of HGF/Met function.
2004 Jul 30
High-throughput computational and experimental techniques in structural genomics.
2004 Oct
Impact of the mother's zinc deficiency on the woman's and newborn's health status.
2005
[Zinc and aluminum concentrations in blood of hemodialysis patients and its impact on the frequency of infections].
2005
Zinc-induced anti-apoptotic effects in SH-SY5Y neuroblastoma cells via the extracellular signal-regulated kinase 1/2.
2005 Apr 27
Zinc in attention-deficit/hyperactivity disorder.
2005 Aug
Angiotensin II receptor blocker-induces blunted taste sensitivity: comparison of candesartan and valsartan.
2005 Aug
Increased plasma levels of zinc in obese adult females on a weight-loss program based on a hypocaloric balanced diet.
2005 Nov-Dec
Copper, zinc, and Cu/Zn ratio in carcinoma of the gallbladder.
2005 Sep 1
Zinc nutritional status of morbidly obese patients before and after Roux-en-Y gastric bypass: a preliminary report.
2006 Apr
The effect of Ramadan on maternal nutrition and composition of breast milk.
2006 Jun
On the mechanism of the conversion of methanol to 2,2,3-trimethylbutane (triptane) over zinc iodide.
2006 Nov 10
Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles.
2007 May
DNA damaging potential of zinc oxide nanoparticles in human epidermal cells.
2009 Mar 28
In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles.
2010 Dec 1
Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles.
2010 Feb
Engineered nanomaterials cause cytotoxicity and activation on mouse antigen presenting cells.
2010 Jan 12
Phosphorylation of p65 is required for zinc oxide nanoparticle-induced interleukin 8 expression in human bronchial epithelial cells.
2010 Jul
Zinc oxide nanoparticle disruption of store-operated calcium entry in a muscarinic receptor signaling pathway.
2010 Oct
Quantum dots trigger immunomodulation of the NFκB pathway in human skin cells.
2011 Jul
Responses of human cells to ZnO nanoparticles: a gene transcription study.
2011 Nov
Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo study.
2011 Sep
Zinc oxide nanoparticles interfere with zinc ion homeostasis to cause cytotoxicity.
2012 Feb
Association of zinc ion release and oxidative stress induced by intratracheal instillation of ZnO nanoparticles to rat lung.
2012 Jun 25
Distinct immunomodulatory effects of a panel of nanomaterials in human dermal fibroblasts.
2012 May 5
Zinc oxide nanoparticles inhibit Ca2+-ATPase expression in human lens epithelial cells under UVB irradiation.
2013 Dec
TiO2, CeO2 and ZnO nanoparticles and modulation of the degranulation process in human neutrophils.
2013 Jul 31
Reactive oxygen species-induced cytotoxic effects of zinc oxide nanoparticles in rat retinal ganglion cells.
2013 Mar
Inorganic salts in atmospheric particulate matter: Raman spectroscopy as an analytical tool.
2013 Nov
Involvement of MyD88 in zinc oxide nanoparticle-induced lung inflammation.
2013 Sep
Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling.
2014 Apr
Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles.
2014 Jan
Zinc oxide nanoparticles induce migration and adhesion of monocytes to endothelial cells and accelerate foam cell formation.
2014 Jul 1
Efficacy of glucarpidase (carboxypeptidase g2) in patients with acute kidney injury after high-dose methotrexate therapy.
2014 May
Ultrasonic assisted removal of sunset yellow from aqueous solution by zinc hydroxide nanoparticle loaded activated carbon: Optimized experimental design.
2015
Synthesis aspects, structural, spectroscopic, antimicrobial and room temperature ferromagnetism of zinc iodide complex with Schiff based ligand.
2015 Jan 25
Practical considerations for the administration of glucarpidase in high-dose methotrexate (HDMTX) induced renal dysfunction.
2015 Sep
Effects of zinc fluoride on inhibiting dentin demineralization and collagen degradation in vitro: A comparison of various topical fluoride agents.
2016 Oct 1
Risk Assessment Study of Fluoride Salts: Probability-Impact Matrix of Renal and Hepatic Toxicity Markers.
2016 Sep
Intense 2.7μm emission in Er(3+) doped zinc fluoride glass.
2017 May 15
Patents

Sample Use Guides

Rats: The dosage of zinc fluoride tetrahydrate (ZnF2 •4H2O) was adjusted to contain 2.1 mg (low-dose group, LG), 4.3 mg (mid-dose group, MG), and 5.4 mg fluoride per 200 g rat body weight (high-dose group, HG) corresponding to 5, 10, and 12.5 % of LD50 values for NaF.
Route of Administration: Oral
In Vitro Use Guide
Prepared ground human enamel specimens were immersed in zinc fluoride solutions containing 250 and 750 ppm F- at pH 6 and 4 for 4 min.
Name Type Language
ZINC GLUCONATE
EP   FCC   GREEN BOOK   HSDB   INCI   MART.   USP   VANDF   WHO-DD  
INCI  
Official Name English
ZINC D-GLUCONATE (1:2)
Common Name English
ZINC GLUCONATE [FCC]
Common Name English
ZINCUM GLUCONICUM
HPUS  
Common Name English
ZINC GLUCONATE [INCI]
Common Name English
ZINCUM GLUCONICUM [HPUS]
Common Name English
BIS(D-GLUCONATO-O1,O2) ZINC
Common Name English
ZINC GLUCONATE [GREEN BOOK]
Common Name English
GLUCONIC ACID ZINC COMPLEX [MI]
Common Name English
ZINC GLUCONATE [MART.]
Common Name English
ZINC GLUCONATE [USP MONOGRAPH]
Common Name English
Zinc gluconate [WHO-DD]
Common Name English
ZINC GLUCONATE [HSDB]
Common Name English
GLUCONIC ACID ZINC COMPLEX
MI  
Common Name English
ZINC GLUCONATE [EP MONOGRAPH]
Common Name English
ZINC GLUCONATE [EP IMPURITY]
Common Name English
ZINC GLUCONATE [VANDF]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 805420
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
DSLD 137 (Number of products:9660)
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
EU-Orphan Drug EU/3/16/1793
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
WHO-ATC A12CB02
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
WHO-VATC QA12CB02
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
CFR 21 CFR 522.2690
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
Code System Code Type Description
MESH
C030691
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY
ECHA (EC/EINECS)
224-736-9
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY
DAILYMED
U6WSN5SQ1Z
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY
DRUG CENTRAL
4343
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY
NCI_THESAURUS
C84248
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
CONCEPT Dietary Supplement
DRUG BANK
DB11248
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PRIMARY
EPA CompTox
DTXSID20894125
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PRIMARY
EVMPD
SUB15756MIG
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PRIMARY
SMS_ID
100000089515
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY
FDA UNII
U6WSN5SQ1Z
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY
RXCUI
58300
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY RxNorm
WIKIPEDIA
ZINC GLUCONATE
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY
CAS
4468-02-4
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY
PUBCHEM
443445
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY
HSDB
1054
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY
MERCK INDEX
m5762
Created by admin on Fri Dec 15 14:57:56 GMT 2023 , Edited by admin on Fri Dec 15 14:57:56 GMT 2023
PRIMARY Merck Index