Details
Stereochemistry | ACHIRAL |
Molecular Formula | C20H24N2OS.ClH |
Molecular Weight | 376.943 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCC(=O)C1=CC2=C(SC3=C(C=CC=C3)N2CCCN(C)C)C=C1
InChI
InChIKey=ZFWVWZODBGTOIL-UHFFFAOYSA-N
InChI=1S/C20H24N2OS.ClH/c1-4-18(23)15-10-11-20-17(14-15)22(13-7-12-21(2)3)16-8-5-6-9-19(16)24-20;/h5-6,8-11,14H,4,7,12-13H2,1-3H3;1H
Propionylpromazine is used as a neuroleptic to combat stress in pets and farm animals. The main use is to combat stress in the transport of pigs. Propionylpromazine was in common use in veterinary practice in the 1950s and 1960s. Propionylpromazine is of interest to JECFA because of the illicit use at pharmacological dosage (< 1 mg/kg i.m.) in the immediate pre-slaughter period.
CNS Activity
Sources: http://www.sigmaaldrich.com/catalog/product/sigma/p7780?lang=en®ion=RUhttp://www.fao.org/fileadmin/user_upload/vetdrug/docs/41-4-propionylpromazine.pdf
Curator's Comment: D2 dopamine receptor antagonist; phenothiazine antipsychotic.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL5131 |
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Target ID: CHEMBL5131 |
357.0 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Propiopromazine Approved UseIndications for use. For oral administration as a tranquilizer. As an aid in handling difficult, excited, and unruly dogs, and in controlling excessive kennel barking, car sickness, and severe dermatitis. It is also indicated for use in minor surgery and prior to routine examinations, laboratory procedures, and diagnostic procedures. |
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Sources: https://www.ncbi.nlm.nih.gov/pubmed/1078293 |
Primary | TRANVET Approved UsePropionylpromazine is used as a neuroleptic to combat stress in pets and farm animals. The main use is to combat stress in the transport of pigs. Launch Date1960 |
PubMed
Title | Date | PubMed |
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Effects of electroanesthesia and a phenothiazine tranquilizer on thermoregulation in the sheep. | 1977 Mar |
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[Effect of phenothiazine derivative on adrenal cortex response of sheep to repeated emotional stress]. | 1991 |
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[The opinion of O. Habler]. | 2001 Aug |
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Development of a rapid screening test for veterinary sedatives and the beta-blocker carazolol in porcine kidney by ELISA. | 2004 Feb |
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Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS. | 2008 Jul |
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Rapid method for the determination of tranquilizers and a beta-blocker in porcine and bovine kidney by liquid chromatography with tandem mass spectrometry. | 2009 Apr 1 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.law.cornell.edu/cfr/text/21/520.2002
Dogs: Administer 0.5 to 2.0 milligrams per pound of body weight once or twice daily, depending upon the degree of tranquilization desired.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11407019
10 uM Propiopromazine produced 95-100% inactivation of Trypanosoma cruzi trypanothione reductase (TR).
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NCI_THESAURUS |
C29710
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CFR |
21 CFR 522.2002
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DBSALT001697
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DTXSID4045187
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24351
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C84114
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U0BND6SD2I
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7681-67-6
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C026328
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD