Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H24N2OS.ClH |
| Molecular Weight | 376.943 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCC(=O)C1=CC=C2SC3=CC=CC=C3N(CCCN(C)C)C2=C1
InChI
InChIKey=ZFWVWZODBGTOIL-UHFFFAOYSA-N
InChI=1S/C20H24N2OS.ClH/c1-4-18(23)15-10-11-20-17(14-15)22(13-7-12-21(2)3)16-8-5-6-9-19(16)24-20;/h5-6,8-11,14H,4,7,12-13H2,1-3H3;1H
Propionylpromazine is used as a neuroleptic to combat stress in pets and farm animals. The main use is to combat stress in the transport of pigs. Propionylpromazine was in common use in veterinary practice in the 1950s and 1960s. Propionylpromazine is of interest to JECFA because of the illicit use at pharmacological dosage (< 1 mg/kg i.m.) in the immediate pre-slaughter period.
CNS Activity
Sources: http://www.sigmaaldrich.com/catalog/product/sigma/p7780?lang=en®ion=RUhttp://www.fao.org/fileadmin/user_upload/vetdrug/docs/41-4-propionylpromazine.pdf
Curator's Comment: D2 dopamine receptor antagonist; phenothiazine antipsychotic.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL5131 |
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Target ID: CHEMBL5131 |
357.0 µM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Propiopromazine Approved UseIndications for use. For oral administration as a tranquilizer. As an aid in handling difficult, excited, and unruly dogs, and in controlling excessive kennel barking, car sickness, and severe dermatitis. It is also indicated for use in minor surgery and prior to routine examinations, laboratory procedures, and diagnostic procedures. |
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| Primary | TRANVET Approved UsePropionylpromazine is used as a neuroleptic to combat stress in pets and farm animals. The main use is to combat stress in the transport of pigs. Launch Date1960 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of inosine on reperfusion injury after cardiopulmonary bypass. | 2010-11-08 |
|
| Rapid method for the determination of tranquilizers and a beta-blocker in porcine and bovine kidney by liquid chromatography with tandem mass spectrometry. | 2009-04-01 |
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| Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS. | 2008-07 |
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| Stability of the tranquilizer drug propionylpromazine hydrochloride in formulated products. | 2005-06 |
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| Development of a rapid screening test for veterinary sedatives and the beta-blocker carazolol in porcine kidney by ELISA. | 2004-02 |
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| Analysis of promazines in bovine livers by high performance liquid chromatography with ultraviolet and fluorimetric detection. | 2003-02-06 |
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| Spectrophotometric determination of vanadium(V) in minerals, steels, soil and biological samples using phenothiazine derivatives. | 2001-08 |
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| [The opinion of O. Habler]. | 2001-08 |
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| [Acute normovolemic hemodilution (ANH). Der Anaesthesist (2000) 49: 939-948]. | 2001-08 |
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| [Inactivation of Trypanosoma cruzi trypanothione reductase by phenothiazine cationic free radicals]. | 2001-06-16 |
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| Trypanosoma cruzi trypanothione reductase is inactivated by peroxidase-generated phenothiazine cationic radicals. | 2001-04 |
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| Gas chromatographic-mass spectrometric analysis of veterinary tranquillizers in urine: evaluation of method performance. | 1999-10-29 |
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| Retrospective evaluation of cardiopulmonary and acid-base variables during long-term balanced anesthesia for experimental surgery in dogs. | 1997-12 |
|
| [Hepatic resection in the fetal rabbit. Histologic comparison of tissue regeneration in the fetus versus the adult]. | 1996-11 |
|
| [Effect of phenothiazine derivative on adrenal cortex response of sheep to repeated emotional stress]. | 1991 |
|
| Effects of electroanesthesia and a phenothiazine tranquilizer on thermoregulation in the sheep. | 1977-03 |
Sample Use Guides
Dogs: Administer 0.5 to 2.0 milligrams per pound of body weight once or twice daily, depending upon the degree of tranquilization desired.
Route of Administration:
Oral
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C29710
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CFR |
21 CFR 522.2002
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admin on Mon Mar 31 17:56:38 GMT 2025 , Edited by admin on Mon Mar 31 17:56:38 GMT 2025
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DBSALT001697
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DTXSID4045187
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24351
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C84114
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U0BND6SD2I
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7681-67-6
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C026328
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
