SODIUM GLUCONATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H11O7.Na
Molecular Weight	218.1371
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

InChI

InChIKey=UPMFZISCCZSDND-JJKGCWMISA-M

InChI=1S/C6H12O7.Na/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h2-5,7-11H,1H2,(H,12,13);/q;+1/p-1/t2-,3-,4+,5-;/m1./s1

HIDE SMILES / InChI

Description
Sources: http://hrcak.srce.hr/file/161891https://www.drugs.com/cdi/ferrlecit.html | https://www.ncbi.nlm.nih.gov/pubmed/28371203

Sodium ferric gluconate complex (brand name Ferrlecit by Sanofi) is an intravenously administered iron product. Ferrlecit is an iron complex. It works by providing the body with its necessary level of iron. Ferric gluconate has been shown to be effective in dialysis and non-dialysis associated anemia of chronic kidney disease (CKD). It has also been shown to be effective in improving responses to EPO in chemotherapy induced anemia.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Ferritin light chain 6 Target ID: P02792\|\|\|Q9BTZ8 Gene ID: 2512.0 Gene Symbol: FTL Target Organism: Homo sapiens (Human) Sources: https://www.drugbank.ca/drugs/DB09517	Binding Agent 1064

Conditions

Condition	Modality	Targets	Highest Phase	Product
Iron deficiency anemia 56 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28391437 https://www.ncbi.nlm.nih.gov/pubmed/26385819 https://www.ncbi.nlm.nih.gov/pubmed/21304025	Primary		Approved 8429	Ferrlecit Approved Use Ferrlecit is indicated for the treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Launch Date 1999
Unknown 2578

C_max

Value	Dose	Co-administered	Analyte	Population
12.9 μg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020955s017lbl.pdf	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		GLUCONATE ION plasma	Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
95 μg × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020955s017lbl.pdf	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		GLUCONATE ION plasma	Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
2 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020955s017lbl.pdf	1.5 mg/kg single, intravenous dose: 1.5 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered:		GLUCONATE ION plasma	Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-034998	http://www.3bsc.com/index/pro_info.php?id=56931
AA Blocks	AA00I9C2	https://www.aablocks.com/goods/Goods/detail?id=AA00I9C2
AHH Chemical co.,ltd	MT-52123	http://www.ahhchemical.com/product/MT-52123.html
AK Scientific, Inc. (AKSCI)	V2121	http://www.aksci.com/item_detail.php?cat=V2121
Aaron Chemicals	AR00IA3U	http://www.aaronchem.com/526-95-4
Acadechem	ACDS-070451	http://www.acadechemical.com/product/145150
Achemtek	0104-021202	http://www.achemtek.com/526-95-4
Acros Organics	AC119890100	https://www.fishersci.com/shop/products/gluconic-acid-50-wt-solution-water-acros-organics-2/AC119890100
Acros Organics	AC119890010	https://www.fishersci.com/shop/products/gluconic-acid-50-wt-solution-water-acros-organics/AC119890010
Acros Organics	AC119890025	https://www.fishersci.com/shop/products/gluconic-acid-50-wt-solution-water-acros-organics/AC119890025
Alfa Aesar	A16806	https://www.alfa.com/en/catalog/A16806/
Alfa Chemistry	157663-13-3	https://www.alfa-chemistry.com/cas_157663-13-3.htm
Angene	AGN-PC-0WADE6	http://www.angenechemical.com/productshow/AGN-PC-0WADE6.html
Aurora Fine Chemicals LLC	A13.111.613	http://online.aurorafinechemicals.com/info?ID=A13.111.613
Avantor Inc	200012-582	https://us.vwr.com/store/product/7516629/sodium-d-gluconate
Avantor Inc	700006-244	https://us.vwr.com/store/product/7829393/d-gluconic-acid-50-in-aqueous-solution
Avantor Inc	700006-248	https://us.vwr.com/store/product/7829393/d-gluconic-acid-50-in-aqueous-solution
Avantor Inc	700006-250	https://us.vwr.com/store/product/7829393/d-gluconic-acid-50-in-aqueous-solution
BLD Pharm	BD305849	http://www.bldpharm.com/products/526-95-4.html
BioSynth	W-109086	https://www.biosynth.com/en/products/life-science/other-biochemicals/products/W-109086.html
Chem Scene	CS-0015343	http://www.chemscene.com/526-95-4.html
Chemspace	CSSB00016994743	https://chem-space.com/CSSB00016994743
Hairui	HR101553	http://www.hairuichem.com/en/product/526-95-4.html
Lab Network	LN00195400	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00195400
Matrix Scientific	99017	https://www.matrixscientific.com/099017.html
MedChem Express	HY-Y0569	https://www.medchemexpress.com/D-Gluconic_acid.html
MuseChem	M102068	https://www.musechem.com/product/M102068.html
MuseChem	R030627	https://www.musechem.com/product/R030627.html
Oakwood	240908	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=121907&ExtHyperLink=1
Oakwood	98946	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=161824&ExtHyperLink=1
Selleck Chemicals	S3595	http://www.selleckchem.com/products/d-gluconic-acid.html
Sigma-Aldrich	G1951_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/g1951?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	12-0635_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/120635?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S054794	http://www.sinfoobiotech.com/product/1058192
Smolecule	S576289	https://www.smolecule.com/products/s576289
TCI (Tokyo Chemical Industry)	G0036	http://www.tcichemicals.com/eshop/en/us/commodity/G0036/index.html
TCI (Tokyo Chemical Industry)	G0038	http://www.tcichemicals.com/eshop/en/us/commodity/G0038/index.html
THE BioTek	bt-432274	https://www.thebiotek.com/product/others/bt-432274
VladaChem	VL279528-25G	https://www.vladachem.com/product.php?products=526-95-4
abcr GmbH	AB116914	http://www.abcr.com/shop/en/AB116914
iChemical	EBD72662	http://www.ichemical.com/products/526-95-4.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs

PubMed

Title	Date	PubMed
Adverse reactions associated with mobile therapeutic apheresis: analysis of 17,940 procedures.	2001	11746539
Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris.	2001	11586012
Effects of P5, a novel oxazolo(3,2-a)pyridine derivative with a long-acting antihypertensive activity, on different agonist-mediated pressor responses in pithed rats.	2001 Apr	11679017
Properties and modulation of alpha human atrial natriuretic peptide (alpha-hANP)-formed ion channels.	2001 Aug	11558674
Electricity and the treatment of hydrofluoric acid burns--the wave of the future or a jolt from the past?	2001 Aug	11505153
Iontophoretic delivery of calcium for experimental hydrofluoric acid burns.	2001 Aug	11505130
Fatal unintentional occupational poisonings by hydrofluoric acid in the U.S.	2001 Aug	11494350
Clinical features, tissue smear and competitive enzyme linked immunosorbent assay as dignostic and prognostic procedures for visceral leishmaniasis in Yemen.	2001 Aug	11478434
Crystallization and preliminary X-ray crystallographic studies of recombinant thermoresistant gluconate kinase GntK from Escherichia coli.	2001 Aug	11468405
Water-soluble adamantane-terminated dendrimers possessing a rhenium core.	2001 Aug 10	11485462
Post-natal ontogeny of stanniocalcin gene expression in rodent kidney and regulation by dietary calcium and phosphate.	2001 Dec	11737588
Iron sucrose or ferric gluconate?	2001 Dec	11728988
Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds.	2001 Dec 1	11692298
Cloning of a Serratia marcescens DNA fragment that induces quinoprotein glucose dehydrogenase-mediated gluconic acid production in Escherichia coli in the presence of stationary phase Serratia marcescens.	2001 Dec 18	11750805
Biosynthesis of poly(3-hydroxybutyrate-co-3-mercaptobutyrate) as a sulfur analogue to poly(3-hydroxybutyrate) (PHB).	2001 Fall	11710011
Excipient-excipient interaction in the design of sustained-release theophylline tablets: in vitro and in vivo evaluation.	2001 Jul	11548856
Cadmium in zinc-containing mineral supplements.	2001 Jul	11474903
Effects of naloxone on calcium turnover in cows affected by milk fever.	2001 Jul	11467812
Imaging and localization of pancreatic insulinomas.	2001 Jul-Aug	11566091
Significance of interferon-gamma in coronary artery bypass surgery.	2001 Jul-Sep	11548832
Substrate selectivity of Gluconobacter oxydans for production of 2,5-diketo-D-gluconic acid and synthesis of 2-keto-L-gulonic acid in a multienzyme system.	2001 Jun	11563824
Single K+ channels in endocrine cells dispersed from the cricket (Gryllus bimaculatus) corpora allata.	2001 Jun	11497122
Hypocalcaemia and hypomagnesaemia due to hydrofluoric acid.	2001 Jun	11463875
Capillary electrophoresis for measuring major and trace anions in thermal water and condensed-steam samples from hydrothermal springs and fumaroles.	2001 Jun 22	11453018
Calcium L-edge XANES study of some calcium compounds.	2001 Mar 1	11512744
Aluminium toxicity and iron homeostasis.	2001 Nov	11709207
Functional atrioventricular block in a preterm infant.	2001 Nov	11668169
Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes.	2001 Nov 1	11597353
An atypical chemical burn.	2001 Nov 3	11705565
Physiological characterisation of Penicillium chrysogenum strains expressing the expandase gene from Streptomyces clavuligerus during batch cultivations. Growth and adipoyl-7-aminodeacetoxycephalosporanic acid production.	2001 Oct	11759685
Hypocalcemia in the newborn.	2001 Oct	11758136
Chemical mechanism of beta-xylosidase from Trichoderma reesei QM 9414: pH-dependence of kinetic parameters.	2001 Oct	11728634
Considerations for optimal iron use for anemia due to chronic kidney disease.	2001 Oct	11726002
99mTc-labeling experiments on CCK(4) by a direct method.	2001 Oct	11578909
Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in ESRD patients.	2001 Oct	11576360
Lack of allergic reaction to Ferrlecit in a patient with a history of severe pruritic reaction with INFeD.	2001 Oct	11549911
Background osmolyte current involved in cell volume regulation of neuroblastoma x glioma hybrid NG108-15 cells.	2001 Sep	11765218
On-line coupling of a miniaturized bioreactor with capillary electrophoresis, via a membrane interface, for monitoring the production of organic acids by microorganisms.	2001 Sep	11678187
Thioglucosidase activity from Sphingobacterium sp. strain OTG1.	2001 Sep	11601617
[Possible treatments of glottic spasm].	2001 Sep	11593774
Intraoperative ultrasound and preoperative localization detects all occult insulinomas; discussion 1025-6.	2001 Sep	11529824
Solubility and relative absorption of copper, iron, and zinc in two milk-based liquid infant formulae.	2001 Sep	11517734
CFTR modulates programmed cell death by decreasing intracellular pH in Chinese hamster lung fibroblasts.	2001 Sep	11502558
Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry.	2001 Sep 14	11587333
Anion modulation of the slowly activating vacuolar channel.	2001 Sep 15	11562795
Hydrofluoric acid burn from a household rust remover.	2001 Sep 3	11587261
Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans.	2001 Sep-Oct	11550076
Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties.	2001 Spring	11749154
Novel degradable polymers combining D-gluconic acid, a sugar of vegetal origin, with lactic and glycolic acids.	2001 Winter	11777404
Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism.	2002 Jan	11746779

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

SODIUM GLUCONATE

Official Name

English

E576

Common Name

English

D-GLUCONIC ACID, SODIUM SALT (1:1)

Common Name

English

Gluconate sodium [WHO-DD]

Common Name

English

SODIUM GLUCONATE [VANDF]

Common Name

English

D-GLUCONIC ACID, MONOSODIUM SALT

Common Name

English

CLEWAT GL

Brand Name

English

SODIUM D-GLUCONATE

Common Name

English

NSC-759599

Code

English

NATRUM GLUCONICUM

Common Name

English

SODIUM GLUCONATE [II]

Common Name

English

MONOSODIUM GLUCONATE

Common Name

English

SODIUM GLUCONATE [MART.]

Common Name

English

E-576

Common Name

English

INS-576

Code

English

SODIUM GLUCONATE [USP MONOGRAPH]

Common Name

English

INS NO.576

Code

English

GLUCONIC ACID, MONOSODIUM SALT, D-

Common Name

English

SODIUM GLUCONATE [ORANGE BOOK]

Common Name

English

E-576-

Code

English

SODIUM GLUCONATE [FCC]

Common Name

English

GLUCONATE SODIUM

Common Name

English

FEMA NO. 4934

Code

English

HELSHAS A

Common Name

English

GLUCONIC ACID SODIUM SALT

Common Name

English

SODIUM GLUCONATE [INCI]

Common Name

English

GLUCONIC ACID SODIUM SALT [MI]

Common Name

English

BVD ADDICRETE

Brand Name

English

Classification Tree Code System Code

CODEX ALIMENTARIUS (GSFA)

INS-576