Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H6NO2.H4N |
| Molecular Weight | 154.1665 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[NH4+].NC1=C(C=CC=C1)C([O-])=O
InChI
InChIKey=ZRAOWOQXOMXTQN-UHFFFAOYSA-N
InChI=1S/C7H7NO2.H3N/c8-6-4-2-1-3-5(6)7(9)10;/h1-4H,8H2,(H,9,10);1H3
DescriptionSources: http://www.dailyhealthmagazine.com/vitamin-l1/https://www.drugs.com/inactive/aminobenzoate-sodium-185.htmlCurator's Comment: description was created based on several sources, including:
DOI: 10.2174/157017906777934926 | https://www.ncbi.nlm.nih.gov/pubmed/12844171
Sources: http://www.dailyhealthmagazine.com/vitamin-l1/https://www.drugs.com/inactive/aminobenzoate-sodium-185.html
Curator's Comment: description was created based on several sources, including:
DOI: 10.2174/157017906777934926 | https://www.ncbi.nlm.nih.gov/pubmed/12844171
Sodium anthranilate is an excipient (pharmacologically inactive substance). Sodium anthranilate (Aminobenzoate sodium ,C7H6NNaO2), also known as sodium 2-aminobenzoate, is an organic amine. Aminobenzoate sodium exists as a yellow powder for use in pharmaceutical processing.
CNS Activity
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Anthranilate hydroxylase |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Inactive ingredient | Desoxyn Approved UseDesoxyn is used in the treatment of adhd; obesity and belongs to the drug classes anorexiants, CNS stimulants. Launch Date1943 |
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| Diagnostic | Unknown Approved UseUnknown |
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| Diagnostic | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Research on tryptophan metabolites "via kynurenine" in epidermis of man and mouse. | 1975 |
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| Accumulation of toxic products degradation of kynurenine in hemodialyzed patients. | 2001 |
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| Report of 19 cases of photoallergic contact dermatitis to sunscreens seen at the Skin and Cancer Foundation. | 2001 Nov |
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| Tranilast slows the progression of advanced diabetic nephropathy. | 2002 |
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| Monitoring glycosylation of therapeutic glycoproteins for consistency using highly fluorescent anthranilic acid. | 2002 |
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| Indole-3-acetic acid metabolism in Lemna gibba undergoes dynamic changes in response to growth temperature. | 2002 Apr |
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| Newer N-substituted anthranilic acid derivatives as potent anti-inflammatory agents. | 2002 Aug |
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| Dynamic diversity of the tryptophan pathway in chlamydiae: reductive evolution and a novel operon for tryptophan recapture. | 2002 Aug 29 |
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| Location of abasic sites in oligodeoxynucleotides by tandem mass spectrometry and by a chemical cleavage initiated by an unusual reaction of the ODN with MALDI matrix. | 2002 Dec |
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| Ortho-aminobenzoic acid-labeled bradykinins in interaction with lipid vesicles: fluorescence study. | 2002 Dec 5 |
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| Induction of anthranilate synthase activity by elicitors in oats. | 2002 Jan-Feb |
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| Role of rhizobial biosynthetic pathways of amino acids, nucleotide bases and vitamins in symbiosis. | 2002 Jul |
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| Characterization of Trp(+) reversions in Escherichia coli strain WP2uvrA. | 2002 Jul |
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| An efficient, convenient synthesis of novel medium-sized 13H-dibenzo[d,h][1,3,7]oxadiazecine-8,14-dione macrolides as anticipated antineoplastic agents. | 2002 Jul |
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| The crystal structure of anthranilate phosphoribosyltransferase from the enterobacterium Pectobacterium carotovorum. | 2002 Jul 17 |
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| Modification of carbon nanofibres for the immobilization of metal complexes: a case study with rhodium and anthranilic acid. | 2002 Jul 2 |
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| Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats. | 2002 Jun |
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| Tranilast prevents activation of transforming growth factor-beta system, leukocyte accumulation, and neointimal growth in porcine coronary arteries after stenting. | 2002 Jun 1 |
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| Biosynthesis of nodulisporic acid A: precursor studies. | 2002 Jun 19 |
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| The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product. | 2002 Jun 7 |
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| High yield formation of o-aminobenzoic acid-7-O-beta-D-(beta-1,6-O-d-glucopyranosyl)-glucopyranosyl ester in cell suspension cultures of Solanum mammosum. | 2002 Mar |
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| [Isolation of strain Pseudomonas sp. ASA2 from a methanogenic community degrading aminobenzoate and aminosalicylate]. | 2002 Mar-Apr |
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| Toxicology and carcinogenesis studies of o-nitrotoluene sulfone (CAS no. 88-72-2) in F344/N rats and B6C3F(1) mice (feed studies). | 2002 May |
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| Sensitive LC determination of ciprofloxacin in pharmaceutical preparations and biological fluids with fluorescence detection. | 2002 May 15 |
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| Intramolecular general base catalyzed ester hydrolysis. The hydrolysis of 2-aminobenzoate esters. | 2002 May 17 |
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| Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones. | 2002 Nov |
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| Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptides. | 2002 Nov 15 |
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| Yeast D-amino acid oxidase: structural basis of its catalytic properties. | 2002 Nov 29 |
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| An improved synthesis of 5,6-dimethylxanthenone-4-acetic acid (DMXAA). | 2002 Oct |
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| Temperature and salts effects on the peptidase activities of the recombinant metallooligopeptidases neurolysin and thimet oligopeptidase. | 2002 Sep |
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| Allergic contact dermatitis from etofenamate without cross-sensitization to other anthranilic acid derivatives. | 2003 |
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| Lateral gene transfer and ancient paralogy of operons containing redundant copies of tryptophan-pathway genes in Xylella species and in heterocystous cyanobacteria. | 2003 |
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| S3 to S3' subsite specificity of recombinant human cathepsin K and development of selective internally quenched fluorescent substrates. | 2003 Aug 1 |
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| Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors. | 2003 Feb 10 |
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| High-performance liquid chromatography assay for 1-deoxy-D-xylulose 5-phosphate synthase activity using fluorescence detection. | 2003 Feb 7 |
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| Complete nucleotide sequence of carbazole/dioxin-degrading plasmid pCAR1 in Pseudomonas resinovorans strain CA10 indicates its mosaicity and the presence of large catabolic transposon Tn4676. | 2003 Feb 7 |
|
| Total synthesis of (-)-fumiquinazolines A, B, C, E, H, and I. Approaches to the synthesis of fiscalin A. | 2003 Jan 24 |
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| Kynurenines and the respiratory parameters on rat heart mitochondria. | 2003 Jan 24 |
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| Avenanthramides in oats (Avena sativa L.) and structure-antioxidant activity relationships. | 2003 Jan 29 |
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| Gene cluster of Arthrobacter ilicis Ru61a involved in the degradation of quinaldine to anthranilate: characterization and functional expression of the quinaldine 4-oxidase qoxLMS genes. | 2003 Jul 25 |
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| Construction and complementation of the first auxotrophic mutant in the spirochaete Leptospira meyeri. | 2003 Mar |
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| Separation of saccharides derivatized with 2-aminobenzoic acid by capillary electrophoresis and their structural consideration by nuclear magnetic resonance. | 2003 Mar 1 |
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| Conjugate additions of o-iodoanilines and methyl anthranilates to acetylenic sulfones. A new route to quinolones including first syntheses of two alkaloids from the medicinal herb Ruta chalepensis. | 2003 Mar 21 |
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| Complexity of coordinative bonding in thallium(I) anthranilates and salicylates. | 2003 Mar 26 |
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| Anthranilic acid derivatives: a new class of non-peptide CCK1 receptor antagonists. | 2003 Mar 6 |
|
| Specificity of S'1 and S'2 subsites of human tissue kallikrein using the reactive-centre loop of kallistatin: the importance of P'1 and P'2 positions in design of inhibitors. | 2003 May 1 |
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| A novel vascular endothelial growth factor-directed therapy that selectively activates cytotoxic prodrugs. | 2003 May 19 |
|
| A concise total synthesis of (+/-)-alantrypinone by a novel hetero-Diels-Alder reaction. | 2003 Sep 4 |
|
| Waste-free and facile solid-state protection of diamines, anthranilic acid, diols, and polyols with phenylboronic acid. | 2003 Sep 5 |
|
| Production and analysis of organic acids in hairy-root cultures of Isatis indigotica Fort. (indigo woad). | 2004 Feb |
Patents
Sample Use Guides
15,000 or 30,000 ppm for the rats, and either 25,000 or 50,000 ppm for the mice, 5 days per week for 78 weeks
Route of Administration:
Oral
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QSN7VZ4A2M
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70346-37-1
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14399617
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
