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Details

Stereochemistry ACHIRAL
Molecular Formula C21H25NO2.ClH
Molecular Weight 359.89
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 1-(-2-PHENETHYL)-4-PHENYL-4-ACETOXYPIPERIDINE HYDROCHLORIDE

SMILES

Cl.CC(=O)OC1(CCN(CCC2=CC=CC=C2)CC1)C3=CC=CC=C3

InChI

InChIKey=WQUUPFMHEQIXIV-UHFFFAOYSA-N
InChI=1S/C21H25NO2.ClH/c1-18(23)24-21(20-10-6-3-7-11-20)13-16-22(17-14-21)15-12-19-8-4-2-5-9-19;/h2-11H,12-17H2,1H3;1H

HIDE SMILES / InChI

Description

4-Piperidinol, 1-phenethyl-4-phenyl acetate (PEPAP) is a synthetic opioid discovered by Janssen in 1960. PEPAP is an analog of meperidine, it is abused and illegally sold on streets as a "synthetic heroin".

CNS Activity

CNS Active
3913
Curator's Comment: Known to be CNS active in mice. Drug of abuse.

Originator

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Compounds related to pethidine-IV. New general chemical methods of increasing the analgesic activity of pethidine.
1960 Feb
Designer drugs that are potent inhibitors of CYP2D6.
2002 Jun

Sample Use Guides

In Vivo Use Guide
In a "hot plate" method compound was injected into mice subcutaneously. EC50 in the test was 6.9 ug/kg
Route of Administration: Other
In Vitro Use Guide
Unknown
Name Type Language
1-(-2-PHENETHYL)-4-PHENYL-4-ACETOXYPIPERIDINE HYDROCHLORIDE
Systematic Name English
4-PIPERIDINOL, 1-PHENETHYL-4-PHENYL-, ACETATE, HYDROCHLORIDE
Systematic Name English
4-PIPERIDINOL, 4-PHENYL-1-(2-PHENYLETHYL)-, 4-ACETATE, HYDROCHLORIDE (1:1)
Systematic Name English
PEPAP HYDROCHLORIDE
Common Name English
Code System Code Type Description
CAS
860229-23-8
Created by admin on Sat Dec 16 11:28:10 GMT 2023 , Edited by admin on Sat Dec 16 11:28:10 GMT 2023
PRIMARY
FDA UNII
QMW2FF5DH3
Created by admin on Sat Dec 16 11:28:10 GMT 2023 , Edited by admin on Sat Dec 16 11:28:10 GMT 2023
PRIMARY
PUBCHEM
139593546
Created by admin on Sat Dec 16 11:28:10 GMT 2023 , Edited by admin on Sat Dec 16 11:28:10 GMT 2023
PRIMARY
NIH
NCATS
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