1-(-2-PHENETHYL)-4-PHENYL-4-ACETOXYPIPERIDINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H25NO2.ClH
Molecular Weight	359.89
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 1-(-2-PHENETHYL)-4-PHENYL-4-ACETOXYPIPERIDINE HYDROCHLORIDE

Structure Search

SMILES

Cl.CC(=O)OC1(CCN(CCC2=CC=CC=C2)CC1)C3=CC=CC=C3

InChI

InChIKey=WQUUPFMHEQIXIV-UHFFFAOYSA-N

InChI=1S/C21H25NO2.ClH/c1-18(23)24-21(20-10-6-3-7-11-20)13-16-22(17-14-21)15-12-19-8-4-2-5-9-19;/h2-11H,12-17H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula	C21H25NO2
Molecular Weight	323.4287
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14406754 | https://www.ncbi.nlm.nih.gov/pubmed/12006905

4-Piperidinol, 1-phenethyl-4-phenyl acetate (PEPAP) is a synthetic opioid discovered by Janssen in 1960. PEPAP is an analog of meperidine, it is abused and illegally sold on streets as a "synthetic heroin".

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12006905	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Compounds related to pethidine-IV. New general chemical methods of increasing the analgesic activity of pethidine.	1960 Feb	14406754
Designer drugs that are potent inhibitors of CYP2D6.	2002 Jun	12006905
QSAR study of 4-phenylpiperidine derivatives as mu opioid agonists by neural network method.	2006 Feb	16403590

Sample Use Guides

In Vivo Use Guide

In a "hot plate" method compound was injected into mice subcutaneously. EC50 in the test was 6.9 ug/kg

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:28:10 GMT 2023` Edited by `admin` on `Sat Dec 16 11:28:10 GMT 2023`
Record UNII	QMW2FF5DH3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1-(-2-PHENETHYL)-4-PHENYL-4-ACETOXYPIPERIDINE HYDROCHLORIDE

Systematic Name

English

4-PIPERIDINOL, 1-PHENETHYL-4-PHENYL-, ACETATE, HYDROCHLORIDE

Systematic Name

English

4-PIPERIDINOL, 4-PHENYL-1-(2-PHENYLETHYL)-, 4-ACETATE, HYDROCHLORIDE (1:1)

Systematic Name

English

PEPAP HYDROCHLORIDE

Common Name

English

Code System Code Type Description

CAS

860229-23-8

Created by admin on Sat Dec 16 11:28:10 GMT 2023 , Edited by admin on Sat Dec 16 11:28:10 GMT 2023

PRIMARY

FDA UNII

QMW2FF5DH3

Created by admin on Sat Dec 16 11:28:10 GMT 2023 , Edited by admin on Sat Dec 16 11:28:10 GMT 2023

PRIMARY

PUBCHEM

139593546

Created by admin on Sat Dec 16 11:28:10 GMT 2023 , Edited by admin on Sat Dec 16 11:28:10 GMT 2023

PRIMARY

Related Record Type Details


					T6LN72I828

1-(-2-PHENETHYL)-4-PHENYL-4-ACETOXYPIPERIDINE

PARENT -> SALT/SOLVATE

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/14406754 | https://www.ncbi.nlm.nih.gov/pubmed/12006905

CNS Activity

Originator

Approval Year

Conditions

Approved Use

PubMed

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14406754 | https://www.ncbi.nlm.nih.gov/pubmed/12006905