1-(-2-PHENETHYL)-4-PHENYL-4-ACETOXYPIPERIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H25NO2
Molecular Weight	323.4287
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 1-(-2-PHENETHYL)-4-PHENYL-4-ACETOXYPIPERIDINE

Structure Search

SMILES

CC(=O)OC1(CCN(CCC2=CC=CC=C2)CC1)C3=CC=CC=C3

InChI

InChIKey=BVURVTVDNWSNFN-UHFFFAOYSA-N

InChI=1S/C21H25NO2/c1-18(23)24-21(20-10-6-3-7-11-20)13-16-22(17-14-21)15-12-19-8-4-2-5-9-19/h2-11H,12-17H2,1H3

HIDE SMILES / InChI

Molecular Formula	C21H25NO2
Molecular Weight	323.4287
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14406754 | https://www.ncbi.nlm.nih.gov/pubmed/12006905

4-Piperidinol, 1-phenethyl-4-phenyl acetate (PEPAP) is a synthetic opioid discovered by Janssen in 1960. PEPAP is an analog of meperidine, it is abused and illegally sold on streets as a "synthetic heroin".

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12006905	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Compounds related to pethidine-IV. New general chemical methods of increasing the analgesic activity of pethidine.	1960 Feb	14406754
Designer drugs that are potent inhibitors of CYP2D6.	2002 Jun	12006905
QSAR study of 4-phenylpiperidine derivatives as mu opioid agonists by neural network method.	2006 Feb	16403590

Sample Use Guides

In Vivo Use Guide

In a "hot plate" method compound was injected into mice subcutaneously. EC50 in the test was 6.9 ug/kg

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:14:37 GMT 2023` Edited by `admin` on `Fri Dec 15 18:14:37 GMT 2023`
Record UNII	T6LN72I828
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1-(-2-PHENETHYL)-4-PHENYL-4-ACETOXYPIPERIDINE

Systematic Name

English

4-PIPERIDINOL, 1-PHENETHYL-4-PHENYL-, ACETATE (ESTER)

Common Name

English

1-(2-PHENYLETHYL)-4-PHENYL-4-ACETOXYPIPERIDINE

Systematic Name

English

4-PIPERIDINOL, 4-PHENYL-1-(2-PHENYLETHYL)-, ACETATE (ESTER)

Common Name

English

MCV 4527

Code

English

PEPAP

Common Name

English

NIH 10460

Code

English

IDS-NP-026

Code

English

IDS-NP-026(SECT.3)

Code

English

1-PHENETHYL-4-PHENYL-4-PIPERIDINOL ACETATE(ESTER)

Common Name

English

Classification Tree Code System Code

DEA NO.

9663