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Details

Stereochemistry ACHIRAL
Molecular Formula 4Fe.3O7P2
Molecular Weight 745.21
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERRIC PYROPHOSPHATE

SMILES

[Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O

InChI

InChIKey=CADNYOZXMIKYPR-UHFFFAOYSA-B
InChI=1S/4Fe.3H4O7P2/c;;;;3*1-8(2,3)7-9(4,5)6/h;;;;3*(H2,1,2,3)(H2,4,5,6)/q4*+3;;;/p-12

HIDE SMILES / InChI

Description
Sources: http://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=falsehttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.htmlhttps://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttps://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505
Curator's Comment: description was created based on several sources, including https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol3/pdf/CFR-1996-title21-vol3-sec182-5375.pdf

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Monsanto Chemicals
44
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Chelating Agent
142
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Approved
8429
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8429
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8429
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Curative
Approved
8429
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

2003
Palliative
Approved
8429
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
[Effects of ferric fluoride compounds on dental enamel].
1954 Nov 15
The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake.
1972 Jan
The absorption of iron as supplements in infant cereal and infant formulas.
1975 May
Contact dermatitis to yellow iron oxide.
1985 Aug
Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats.
1989
New phosphate binding agents: ferric compounds.
1999 Jun
Non-invasive and non-destructive micro-XRF and micro-Raman analysis of a decorative wallpaper from the beginning of the 19th century.
2007 Feb
Metal-mediated cyclization of aryl and benzyl glycidyl ethers: a complete scenario.
2008 Dec 17
Fabrication of FeF3 Nanoflowers on CNT branches and their application to high power lithium rechargeable batteries.
2010 Dec 7
Microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions and antimicrobial activities of the products.
2014 Aug 26
FeF(3) catalyzed cascade C-C and C-N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition.
2014 May
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
2015 Nov 3
Superior electrochemical performance of N-doped nanocrystalline FeF(3)/C with a single-step solid-state process.
2016 Oct 4
Ferric Chloride-induced Murine Thrombosis Models.
2016 Sep 5
Effect of iron and carbon monoxide on fibrinogenase-like degradation of plasmatic coagulation by venoms of four Crotalus species.
2017 Jan
Patents

Patents

20080188032
44
20090216060
44
6258758
44
US 5206265 A
44
US2385188
44
US3873678
44
US4364871
44
US6881255
44
US6903235
44
US7198668
44
US8071067
44

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
FERRIC PYROPHOSPHATE
FCC   HSDB   MART.   MI   VANDF   WHO-DD  
Common Name English
FERRIC PYROPHOSPHATE [VANDF]
Common Name English
DIPHOSPHORIC ACID IRON(3+) SALT (3:4)
Common Name English
IRON (AS PYROPHOSPHATE)
Common Name English
FERRIC PYROPHOSPHATE [FCC]
Common Name English
IRON(III) PYROPHOSPHATE
Common Name English
FERRIC PYROPHOSPHATE [HSDB]
Common Name English
Ferric pyrophosphate [WHO-DD]
Common Name English
FERRIC PYROPHOSPHATE [MART.]
Common Name English
FERRIC PYROPHOSPHATE [MI]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 184.1304
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
Code System Code Type Description
RXCUI
1607976
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY RxNorm
EVMPD
SUB13847MIG
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
CHEBI
132767
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
NCI_THESAURUS
C82284
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
DRUG BANK
DB09147
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
MERCK INDEX
m5327
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
CONCEPT Industrial Aid
ECHA (EC/EINECS)
233-190-0
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
DAILYMED
QK8899250F
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
SMS_ID
100000078920
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
WIKIPEDIA
Iron(III) pyrophosphate
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
EPA CompTox
DTXSID6047600
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
HSDB
454
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
CAS
10058-44-3
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
MESH
C049051
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
FDA UNII
QK8899250F
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
PUBCHEM
24877
Created by admin on Fri Dec 15 15:41:15 GMT 2023 , Edited by admin on Fri Dec 15 15:41:15 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of FERRIC CATION
PARENT (SALT/SOLVATE)
Structure of PYROPHOSPHORIC ACID
SUBSTANCE RECORD
Structure of FERRIC PYROPHOSPHATE
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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