FERROCHOLINATE

First approved in 1953

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H4O7.C5H14NO.Fe.3H2O
Molecular Weight	402.153
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O.O.[Fe+3].C[N+](C)(C)CCO.[O-]C(=O)CC([O-])(CC([O-])=O)C([O-])=O

InChI

InChIKey=UQSASSBWRKBREL-UHFFFAOYSA-K

InChI=1S/C6H7O7.C5H14NO.Fe.3H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;1-6(2,3)4-5-7;;;;/h1-2H2,(H,7,8)(H,9,10)(H,11,12);7H,4-5H2,1-3H3;;3*1H2/q-1;+1;+3;;;/p-3

HIDE SMILES / InChI

Description
Sources: https://www.aemps.gob.es/cima/pdfs/es/ft/54556/54556_ft.pdf
Curator's Comment: description was created based on several sources, including: http://www.druginfosys.com/drug.aspx?drugcode=1316&type=1 | http://www.vademecum.es/medicamento-podertonic+adultos_3181

Ferrocholinate is a chelate prepared by reacting equal quantities of freshly precipitated ferric chloride with choline dihydrogen citrate. Ferrocholinate is used as a source of iron in iron deficiency anemia. Ferrocholinate absorption is increased by simultaneous administration of ascorbic acid. Absorption reduced by antacids, cholestyramine or proton pump inhibitors (omeprazole, pantoprazole, lansoprazole). The following adverse effects may occur: occasionally, gastrointestinal disorders (stomach pain, nausea, constipation or diarrhea) may appear, which usually disappear quickly after the dose is reduced or, if necessary, after treatment discontinuation. Darkness of stool: it is frequently observed during treatment and is safe for the patient. Allergic reactions may occur, also.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
hemoglobin metabolic process 2 Target ID: GO:0020027 Sources: https://www.aemps.gob.es/cima/pdfs/es/ft/54556/54556_ft.pdf	Modulator 828

Conditions

Condition	Modality	Highest Phase	Product
Iron deficiency anemia 56 Sources: http://www.druginfosys.com/drug.aspx?drugcode=1316&type=1	Primary	Approved 8429	FERROLIP Approved Use Ferrocholinate is primarily indicated in conditions like iron deficiency anaemia. Launch Date 1960
Chronic bleeding 2 Sources: http://www.vademecum.es/medicamento-podertonic+adultos_3181	Primary	Approved 8429	FERROLIP Approved Use Treatment of iron deficiency states and iron deficiency anemia in adults and children, for deficient iron absorption, chronic bleeding or in situations where there is an increase of iron demands such as pregnancy or breastfeeding. Launch Date 1960
Iron absorption deficiency 2 Sources: https://www.aemps.gob.es/cima/pdfs/es/ft/54556/54556_ft.pdf	Primary	Approved 8429	FERROLIP Approved Use Treatment of iron deficiency states and iron deficiency anemia in adults and children, for deficient iron absorption, chronic bleeding or in situations where there is an increase of iron demands such as pregnancy or breastfeeding. Launch Date 1960

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-054251	http://www.3bsc.com/index/pro_info.php?id=92722
BOC Sciences	65228-13-9	https://www.bocsci.com/ferric-choline-citrate-cas-65228-13-9-item-205804.html
PubChem	76966607	https://pubchem.ncbi.nlm.nih.gov/compound/76966607

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

1 tablet (100 mg) daily Adults daily dose is equivalent to 112.6 mg Fe3. Take this medication preferably a few hours before meals. Duration of treatment depends on nature and severity of iron deficiency.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

FERROCHOLINATE

Official Name

English

FERROLIP

Brand Name

English

FERROCHOLINATE [MI]

Common Name

English

FERROCHOLINATE [MART.]

Common Name

English

Ferrocholinate [WHO-DD]

Common Name

English

FERRIC CHOLINE CITRATE

Common Name

English

IRON CHOLINE CITRATE COMPLEX

Common Name

English

ferrocholinate [INN]

Common Name

English

(HYDROGEN CITRATO(3-))TRIAQUOIRON, CHOLINE SALT

Common Name

English

ETHANAMINIUM, 2-HYDROXY-N,N,N-TRIMETHYL-, (OC-6-44)-TRIAQUA(2-(HYDROXY-.KAPPA.O)-1,2,3-PROPANETRICARBOXYLATO(4-)-.KAPPA.O1,.KAPPA.O2)FERRATE(1-) (1:1)

Common Name

English

FRE-SOL

Brand Name

English

Classification Tree Code System Code

CFR

21 CFR 172.370