Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C22H25N3O3.C4H6O6 |
Molecular Weight | 529.539 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O[C@H]([C@@H](O)C(O)=O)C(O)=O.COC1=C(C=CC=C1)N2CCN(CCC3=CNC4=C3C=C5OCOC5=C4)CC2
InChI
InChIKey=FDYHSJCNTRLQCR-LREBCSMRSA-N
InChI=1S/C22H25N3O3.C4H6O6/c1-26-20-5-3-2-4-19(20)25-10-8-24(9-11-25)7-6-16-14-23-18-13-22-21(12-17(16)18)27-15-28-22;5-1(3(7)8)2(6)4(9)10/h2-5,12-14,23H,6-11,15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5919502
Curator's Comment: Solypertine selectively blocked the conditioned avoidance response in rats. Solypertine potentiated hexobarbitone sleeping time, caused hypothermia and afforded protection from amphetamine toxicity inaggregated mice.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5919502
Mice: LD50 = 81.5 mg/kg.
Solypertine (WIN-18413-2) in doses of 4 and 8 mg/kg, caused behavioural depression and apathy in the cats.
Route of Administration:
Intraperitoneal
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29710
Created by
admin on Fri Dec 15 15:11:46 GMT 2023 , Edited by admin on Fri Dec 15 15:11:46 GMT 2023
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NCI_THESAURUS |
C66883
Created by
admin on Fri Dec 15 15:11:46 GMT 2023 , Edited by admin on Fri Dec 15 15:11:46 GMT 2023
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C152391
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107432
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267773
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LGH2D06D4K
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5591-43-5
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CHEMBL1739674
Created by
admin on Fri Dec 15 15:11:46 GMT 2023 , Edited by admin on Fri Dec 15 15:11:46 GMT 2023
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PRIMARY |
ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD