Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H19NO2 |
| Molecular Weight | 233.3062 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC(=O)C1(CCNCC1)C2=CC=CC=C2
InChI
InChIKey=QKHMFBKXTNQCTM-UHFFFAOYSA-N
InChI=1S/C14H19NO2/c1-2-17-13(16)14(8-10-15-11-9-14)12-6-4-3-5-7-12/h3-7,15H,2,8-11H2,1H3
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer. | 1977 Jun |
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| Normeperidine toxicity. | 1986 May |
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| Possible roles of normeperidine and hyponatremia in a postoperative death. | 1987 Nov 15 |
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| Norpethidine induced myoclonus in a patient with renal failure. | 1989 Dec |
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| Normorphine, a neurotoxic metabolite? | 1990 Mar 24 |
|
| Normeperidine-induced seizures in hereditary coproporphyria. | 1990 Nov |
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| Toxicity of norpethidine in sickle cell crisis. | 1992 Jun 6 |
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| Norpethidine accumulation and generalized seizure during pethidine patient-controlled analgesia. | 1999 Jun |
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| Seizures due to norpethidine toxicity. | 2000 Aug |
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| Successful treatment of normeperidine neurotoxicity by hemodialysis. | 2000 Jan |
|
| CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. | 2004 Sep |
|
| Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study. | 2007 |
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| Detection of methylphenidate in the hair of children treated with Ritalin. | 2007 Nov-Dec |
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| Seizures in an Alzheimer's disease patient as a complication of colonoscopy premedication with meperidine. | 2008 Jan |
|
| Role of active metabolites in the use of opioids. | 2009 Feb |
|
| Cerebellar and oculomotor dysfunction induced by rapid infusion of pethidine. | 2014 Mar 11 |
Patents
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| Classification Tree | Code System | Code | ||
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DEA NO. |
9233
Created by
admin on Sat Dec 16 08:12:33 GMT 2023 , Edited by admin on Sat Dec 16 08:12:33 GMT 2023
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| Code System | Code | Type | Description | ||
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100000088221
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201-008-9
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DTXSID50227806
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23821
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SUB21925
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77-17-8
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32414
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Norpethidine
Created by
admin on Sat Dec 16 08:12:33 GMT 2023 , Edited by admin on Sat Dec 16 08:12:33 GMT 2023
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PRIMARY | Norpethidine (Normeperidine, Pethidine Intermediate B) is a 4-phenylpiperidine derivative that is both a metabolite of and a precursor to pethidine (meperidine). It is scheduled by UN Single Convention on Narcotic Drugs. | ||
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JG096PMW2N
Created by
admin on Sat Dec 16 08:12:33 GMT 2023 , Edited by admin on Sat Dec 16 08:12:33 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)
