CALCIUM CARBONATE

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	CO3.Ca
Molecular Weight	100.087
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Ca++].[O-]C([O-])=O

InChI

InChIKey=VTYYLEPIZMXCLO-UHFFFAOYSA-L

InChI=1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2

HIDE SMILES / InChI

Description
Sources: http://www.globalrph.com/calcium_supplements.htm | https://www.ncbi.nlm.nih.gov/pubmed/26265479http://apps.who.int/iris/bitstream/10665/43579/1/9789241530729_eng.pdfhttps://www.drugs.com/inactive/calcium-phosphate-dibasic-anhydrous-463.html
Curator's Comment: description was created based on several sources, including https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260884.htm | http://www.webmd.com/drugs/2/drug-159847/calcium-phosphate-dibasic-oral/details

Anhydrous dibasic calcium phosphate is a calcium salt of phosphoric acid. It is used as a diluent in pharmaceutical industry, in some toothpastes as a polishing agent. Calcium phosphate is generally recognized as safe by FDA. Dibasic calcium phosphate is ised as a supplement to treat conditions associated with calcium deficit, such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany)

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Hypocalcemia 75 Sources: http://www.globalrph.com/calcium_supplements.htm	Primary	Not Provided 504	Unknown Approved Use Unknown
Chronic obstructive pulmonary disease 174 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26265479	Palliative	Phase I 428	Unknown Approved Use Unknown
Cystic fibrosis 120 Sources: https://clinicaltrials.gov/ct2/show/NCT01543191	Palliative	Phase I 428	Unknown Approved Use Unknown
Unknown 2578
Hypocalcemia 75 Sources: https://www.drugs.com/mmx/calcium-phosphate-dibasic.html	Primary	Approved 8429	Unknown Approved Use Hypocalcemia, chronic (treatment) — Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency, oral calcium salts may be administered concomitantly with vitamin D analogs. However, calcium phosphate should not be used in patients with hypoparathyroidism or renal failure, since phosphate levels may be too high and giving more phosphate would exacerbate the condition. Calcium supplements should not be used in hyperparathyroidism, unless the need for a calcium supplement is high and the patient is carefully monitored. For treatment of hypocalcemia, supplementation is preferred

PubMed

Title	Date	PubMed
1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes.	1999 Feb	10048583
Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes.	1999 Sep	10469331
Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity.	1999 Sep 20	10509933
alpha(1E) subunits form the pore of three cerebellar R-type calcium channels with different pharmacological and permeation properties.	2000 Jan 1	10627594
Vanadate induces calcium signaling, Ca2+ release-activated Ca2+ channel activation, and gene expression in T lymphocytes and RBL-2H3 mast cells via thiol oxidation.	2000 Jan 15	10623810
Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations.	2001 Apr 7	11298490
Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds.	2001 Dec 21	11592964
Cloning and characterization of a novel human histamine receptor.	2001 Mar	11181941
Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines.	2001 Mar	11181528
Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities.	2001 Nov	11701772
Regression of ventral striatum hypometabolism after calcium/calcitriol therapy in paroxysmal kinesigenic choreoathetosis due to idiopathic primary hypoparathyroidism.	2001 Nov	11606688
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.	2001 Nov 30	11577072
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.	2001 Oct	11606325
Regional differences in functional receptor distribution and calcium mobilization in the intact human lens.	2001 Sep	11527950
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.	2001 Sep 7	11553362
Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats.	2002	12421626
Interaction of intravenous anesthetics with recombinant human M1-M3 muscarinic receptors expressed in chinese hamster ovary cells.	2002 Dec	12456425
Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	2002 Mar 15	11897840
Long-term remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo: a systematic review.	2014 Jul	24705069
Dietary interventions for mineral and bone disorder in people with chronic kidney disease.	2015 Sep 16	26376110

Patents

Sample Use Guides

In Vivo Use Guide

oral: 500 to 2000 mg elemental calcium a day, in divided doses (bid-qid). inhalation: In a single-blind, phase 1B proof of concept study, 24 subjects were enrolled to sequentially receive three doses of PUR118 (calcium lactate inhalation powder (CLIP) formulation) (5.5 mg, n = 18; 11.0 mg, n = 18; 2.8 mg, n = 16). Each dose was inhaled 3 times (1, 13, 25 h, preceded by 2 puffs salbutamol) before the ozone exposure (250 ppb, 3 h intermittent exercise). Sputum was induced 3 h after the end of exposure.

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

CALCIUM CARBONATE

Official Name

English

INS-170(I)

Code

English

MARBLE DUST

Common Name

English

CALCII CARBONAS [WHO-IP LATIN]

Common Name

English

GLAUBERITUM

Common Name

English

PRECPITATED CALCIUM CARBONATE [JAN]

Common Name

English

LIMESTONE, GROUND

Common Name

English

HYDROLYZED PEARL

Official Name

English

HYDROLYZED PEARL [INCI]

Common Name

English

CALCIUM CARBONATE COMPONENT OF PEPCID COMPLETE

Common Name

English

CALCITE [INCI]

Common Name

English

Calcium carbonate (1:1)

Systematic Name

English

CALCIUM CARBONATE [HSDB]

Common Name

English

CALCITE

Official Name

English

CALCIUM (AS CARBONATE)

Common Name

English

CALCIUM CARBONATE [FCC]

Common Name

English

CALCIUM CARBONATE DC (SPRAY DRIED) [NDI]

Common Name

English

NDI 443 [FDMS]

Code

English

PEPCID COMPLETE COMPONENT CALCIUM CARBONATE

Common Name

English

LIMESTONE, GROUND [FCC]

Common Name

English

Chalk [WHO-DD]

Common Name

English

CALCIUM CARBONATE [EP MONOGRAPH]

Common Name

English

CALCIUM CARBONATE [WHO-IP]

Common Name

English

CHALK

Official Name

English

HAN SHUI SHI

Common Name

English

CALCITE (CA(CO3))

Common Name

English

CALCIUM CARBONATE [MI]

Common Name

English

CALCIUM CARBONATE [INCI]

Common Name

English

CALCIUM CARBONATE [MART.]

Common Name

English

CHALK [INCI]

Common Name

English

E-170(I)

Code

English

INS NO.170(I)

Code

English

PHX CAL-CARB BUFFER

Brand Name

English

CI 77220

Official Name

English

CALCIUM (AS CALCIUM CARBONATE)

Common Name

English

CALCIUM CARBONATE [USP-RS]

Common Name

English

CALCIUM CARBONATE [USP MONOGRAPH]

Common Name

English

CALCIUM CARBONATE [ORANGE BOOK]

Common Name

English

CALCIUM (AS CALCIUM CARBONATE) [VANDF]

Common Name

English

CALCIUM (AS CARBONATE) [VANDF]

Common Name

English

LIMESTONE

Common Name

English

CALCIUM CARBONATE [VANDF]

Common Name

English

CALCITUM

Common Name

English

PRECPITATED CALCIUM CARBONATE

Common Name

English

CALCIUM CARBONATE [II]

Common Name

English

CI 77220 [INCI]

Common Name

English

Calcium carbonate [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QA12AA04