U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C23H33N2O.I
Molecular Weight 480.4254
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ISOPROPAMIDE IODIDE

SMILES

[I-].CC(C)[N+](C)(CCC(C(N)=O)(C1=CC=CC=C1)C2=CC=CC=C2)C(C)C

InChI

InChIKey=BFSMWENDZZIWPW-UHFFFAOYSA-N
InChI=1S/C23H32N2O.HI/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21;/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26);1H

HIDE SMILES / InChI

Description

Isopropamide is a quaternary ammonium antimuscarinic with peripheral effects similar to those of atropine. It has been used as an adjunct in the treatment of peptic ulcer disease, in the relief of gastro-intestinal and urinary tract disorders associated with smooth muscle spasm, in rhinitis, and the relief of symptoms of cold.

Originator

Janssen
54
Curator's Comment: reference retrieved from http://www.drugfuture.com/chemdata/isopropamide-iodide.html

Approval Year

1957
114
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
DARBID

Approved Use

Isopropamide (I) is a quaternary ammonium antimuscarinic with peripheral effects similar to those of atropine. It has been used as an adjunct in the treatment of peptic ulcer disease, in the relief of gastro-intestinal and urinary tract disorders associated with smooth muscle spasm, in rhinitis, and the relief of symptoms of cold.

Launch Date

1957
Primary
Approved
8429
DARBID

Approved Use

Isopropamide (I) is a quaternary ammonium antimuscarinic with peripheral effects similar to those of atropine. It has been used as an adjunct in the treatment of peptic ulcer disease, in the relief of gastro-intestinal and urinary tract disorders associated with smooth muscle spasm, in rhinitis, and the relief of symptoms of cold.

Launch Date

1957
Doses

Doses

DosePopulationAdverse events​
40 mg single, oral (max)
MTD
Dose: 40 mg
Route: oral
Route: single
Dose: 40 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/234981
Page: p.537
unhealthy, 27-53
n = 7
Health Status: unhealthy
Condition: Duodenal ulcer
Age Group: 27-53
Sex: M+F
Population Size: 7
Sources:
https://pubmed.ncbi.nlm.nih.gov/234981
Page: p.537
Sources:
https://pubmed.ncbi.nlm.nih.gov/234981
Page: p.537
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY570133
https://www.001chemical.com/chem/7492-32-2
ABI Chem
AC1L1GON
Alfa Chemistry
7492-32-2
AstaTech
T72872
BOC Sciences
24353-18-2
BOC Sciences
71-81-8
BOC Sciences
7492-32-2
Chem Scene
CS-0013628
ChemMol
99052950
http://www.chemmol.com/chemmol/99052950.html
ChemTik
CTK4F3460
Chemieliva Pharmaceutical Co., Ltd
PBCM1405854
Compound Cloud
3775
Compound Cloud
6284
DC Chemicals
DC31720
http://www.dcchemicals.com//product_show-Isopropamide.html
Hairui
HR136820
MedChem Express
HY-B1667
MolPort
MolPort-003-666-211
Molcore
MC570133
https://www.molcore.com/product/7492-32-2
MuseChem
I007382
MuseChem
M082189
MuseChem
R044777
NCI Plated 2007
15521
NCI Plated 2007
15548
NovoSeek
3775
Smolecule
S530944
http://www.smolecule.com/products/s530944
THE BioTek
bt-272350
https://www.thebiotek.com/product/inhibitors/bt-272350
TargetMol
T5051
TimTec
SBB058159
TimTec
ST51015028
ZINC
ZINC000001530668
http://zinc15.docking.org/substances/ZINC000001530668
eMolecules
1987293
eMolecules
4927826
eNovation Chemicals
D674430
https://www.enovationchem.com/ProductDetails.asp?ProductID=D674430
mcule
MCULE-1763411393
https://mcule.com/MCULE-1763411393/
PubMed

PubMed

TitleDatePubMed
Spectrophotometric determination of trifluoperazine HCl and isopropamide iodide in binary mixture using second derivative and second derivative of the ratio spectra methods.
2001 Sep
Derivative spectrophotometric, thin layer chromatographic-densitometric and high performance liquid chromatographic determination of trifluoperazine hydrochloride in presence of its hydrogen peroxide induced-degradation product.
2002 Jan 1
Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice.
2005 Sep 17
Annotation of novel neuropeptide precursors in the migratory locust based on transcript screening of a public EST database and mass spectrometry.
2006 Aug 9
Simultaneous RP-HPLC Estimation of Trifluoperazine Hydrochloride and Chlordiazepoxide in Tablet Dosage Forms.
2009 Sep
Spectrophotometric determination of isopropamide iodide and trifluoperazine hydrochloride in presence of trifluoperazine oxidative degradate.
2010 Apr
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
2-Hydroxy-N,N'-diisopropylpropane-1,3-diaminium dichloride.
2010 Jun 23
Patents

Patents

JPH07188040A
4
JPH08325142A
4

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
ISOPROPAMIDE IODIDE
GREEN BOOK   INN   JAN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
INN  
Official Name English
DARBID
Brand Name English
R-79
Code English
BENZENEPROPANAMINIUM, .GAMMA.-(AMINOCARBONYL)-N-METHYL-N,N-BIS(1-METHYLETHYL)-.GAMMA.-PHENYL-, IODIDE
Systematic Name English
NSC-15521
Code English
MARYGIN-M
Brand Name English
ISAMID
Brand Name English
ISOPROPAMIDE IODIDE [VANDF]
Common Name English
Isopropamide iodide [WHO-DD]
Common Name English
ISOPROPAMIDE IODIDE [MI]
Common Name English
ISOPROPAMIDE IODIDE [USP MONOGRAPH]
Common Name English
VESALIUM COMPONENT ISOPROPAMIDE IODIDE
Brand Name English
PRIAMIDE
Brand Name English
ISOPROPAMIDE IODIDE [ORANGE BOOK]
Common Name English
ISOPROPAMIDE IODIDE [GREEN BOOK]
Common Name English
SKF-4740
Code English
SANULCIN
Brand Name English
isopropamide iodide [INN]
Common Name English
TYRIMIDE
Brand Name English
ISOPROPAMIDE IODIDE [MART.]
Common Name English
ISOPROPAMIDE IODIDE [JAN]
Common Name English
ISOPROPAMIDE IODIDE [USP-RS]
Common Name English
PRIAZIMIDE
Brand Name English
ISOPROPAMIDE IODIDE COMPONENT OF VESALIUM
Brand Name English
(3-Carbamoyl-3,3-diphenylpropyl)diisopropylmethylammonium iodide
Systematic Name English
ISOPROPAMIDE (AS IODIDE) [VANDF]
Common Name English
DIPRAMIDE
Brand Name English
PIACCAMIDE
Brand Name English
DIPRAMID
Brand Name English
BENZENEPROPANAMINIUM, .GAMMA.-(AMINOCARBONYL)-N-METHYL-N,N-BIS(1-METHYLETHYL)-.GAMMA.-PHENYL-, IODIDE (1:1)
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C66880
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
Code System Code Type Description
MERCK INDEX
m6518
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY Merck Index
FDA UNII
E0KNA372SZ
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
SMS_ID
100000092378
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
EVMPD
SUB08332MIG
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
MESH
C084831
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201232
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
EPA CompTox
DTXSID30221221
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
NSC
15521
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
NCI_THESAURUS
C65982
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
DRUG BANK
DBSALT001023
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-766-8
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
INN
715
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
RXCUI
6051
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY RxNorm
PUBCHEM
6284
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
CAS
71-81-8
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
RS_ITEM_NUM
1350002
Created by admin on Sat Dec 16 17:02:34 GMT 2023 , Edited by admin on Sat Dec 16 17:02:34 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of ISOPROPAMIDE
SUBSTANCE RECORD
Structure of ISOPROPAMIDE IODIDE
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966