Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H22N2O2.C4H4O4 |
| Molecular Weight | 378.4195 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)\C=C\C(O)=O.COC1=CC=C(CCN=C2CCCN2C)C=C1OC
InChI
InChIKey=KVQJERHSAVDWSB-UGDAXESUSA-N
InChI=1S/C15H22N2O2.C4H4O4/c1-17-10-4-5-15(17)16-9-8-12-6-7-13(18-2)14(11-12)19-3;5-3(6)1-2-4(7)8/h6-7,11H,4-5,8-10H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b16-15+;2-1+
Mixidine is negative chronotropic agent patented by McNeil Laboratories. Mixidine produced a dose-related decrease in heart rate elevated reflexly by aminophylline, by beta-adrenergic stimulation induced by isoproterenol, by sympathetic nerve stimulation and by intravenous infusion of glucagon. Mixidineattenuated the increase in contractile force produced by sympathetic nerve stimulation but not that induced by isoproterenol. The compound antagonized the increase in the rate of isolated guinea-pig atria induced by both isoproterenol and histamine. In the conscious dog, Mixidine caused no decrease in resting heart rate, mean arterial pressure and cardiac output. It reduced atropine-induced sinus tachycardia as well as that induced by treadmill exercise.
Approval Year
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C017540
Created by
admin on Fri Dec 15 15:08:13 GMT 2023 , Edited by admin on Fri Dec 15 15:08:13 GMT 2023
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907N50REU7
Created by
admin on Fri Dec 15 15:08:13 GMT 2023 , Edited by admin on Fri Dec 15 15:08:13 GMT 2023
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67958-13-8
Created by
admin on Fri Dec 15 15:08:13 GMT 2023 , Edited by admin on Fri Dec 15 15:08:13 GMT 2023
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6441760
Created by
admin on Fri Dec 15 15:08:13 GMT 2023 , Edited by admin on Fri Dec 15 15:08:13 GMT 2023
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ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
