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Details

Stereochemistry ACHIRAL
Molecular Formula C15H22N2O2.C4H4O4
Molecular Weight 378.4195
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of MIXIDINE FUMARATE

SMILES

OC(=O)\C=C\C(O)=O.COC1=CC=C(CCN=C2CCCN2C)C=C1OC

InChI

InChIKey=KVQJERHSAVDWSB-UGDAXESUSA-N
InChI=1S/C15H22N2O2.C4H4O4/c1-17-10-4-5-15(17)16-9-8-12-6-7-13(18-2)14(11-12)19-3;5-3(6)1-2-4(7)8/h6-7,11H,4-5,8-10H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b16-15+;2-1+

HIDE SMILES / InChI

Molecular Formula C15H22N2O2
Molecular Weight 262.3474
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Mixidine is negative chronotropic agent patented by McNeil Laboratories. Mixidine produced a dose-related decrease in heart rate elevated reflexly by aminophylline, by beta-adrenergic stimulation induced by isoproterenol, by sympathetic nerve stimulation and by intravenous infusion of glucagon. Mixidineattenuated the increase in contractile force produced by sympathetic nerve stimulation but not that induced by isoproterenol. The compound antagonized the increase in the rate of isolated guinea-pig atria induced by both isoproterenol and histamine. In the conscious dog, Mixidine caused no decrease in resting heart rate, mean arterial pressure and cardiac output. It reduced atropine-induced sinus tachycardia as well as that induced by treadmill exercise.

Approval Year

PubMed

PubMed

TitleDatePubMed
Cardiovascular profile of mixidine fumarate, a compound which attenuates myocardial chronotropic responses.
1980 Mar
Cardiovascular actions of mixidine fumarate.
1980 Nov 21
Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Dec 15 15:08:13 UTC 2023
Edited
by admin
on Fri Dec 15 15:08:13 UTC 2023
Record UNII
907N50REU7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MIXIDINE FUMARATE
Common Name English
1-METHYL-2-((3,4-DIMETHOXYPHENETHYL)IMINO)PYRROLIDINE HYDROGEN FUMARATE
Systematic Name English
BENZENEETHANAMINE, 3,4-DIMETHOXY-N-(1-METHYL-2-PYRROLIDINYLIDENE)-, (E)-2-BUTENEDIOATE (1:1)
Systematic Name English
3,4-DIMETHOXY-N-(1-METHYL-2-PYRROLIDINYLIDENE)BENZENEETHANAMINE FUMARATE
Systematic Name English
BENZENEETHANAMINE, 3,4-DIMETHOXY-N-(1-METHYL-2-PYRROLIDINYLIDENE)-, (2E)-2-BUTENEDIOATE (1:1)
Systematic Name English
Code System Code Type Description
MESH
C017540
Created by admin on Fri Dec 15 15:08:13 UTC 2023 , Edited by admin on Fri Dec 15 15:08:13 UTC 2023
PRIMARY
FDA UNII
907N50REU7
Created by admin on Fri Dec 15 15:08:13 UTC 2023 , Edited by admin on Fri Dec 15 15:08:13 UTC 2023
PRIMARY
CAS
67958-13-8
Created by admin on Fri Dec 15 15:08:13 UTC 2023 , Edited by admin on Fri Dec 15 15:08:13 UTC 2023
PRIMARY
PUBCHEM
6441760
Created by admin on Fri Dec 15 15:08:13 UTC 2023 , Edited by admin on Fri Dec 15 15:08:13 UTC 2023
PRIMARY
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ACTIVE MOIETY